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Protein

Sodium channel subunit beta-2

Gene

Scn2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-2
Gene namesi
Name:Scn2b
Synonyms:Gm183
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:106921. Scn2b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 159130ExtracellularSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Topological domaini181 – 21535CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929By similarityAdd
BLAST
Chaini30 – 215186Sodium channel subunit beta-2PRO_0000045177Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi50 ↔ 127PROSITE-ProRule annotation
Disulfide bondi55 – 55Interchain; with alpha subunitPROSITE-ProRule annotation
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Modified residuei192 – 1921PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ56A07.
PaxDbiQ56A07.
PRIDEiQ56A07.

PTM databases

iPTMnetiQ56A07.
PhosphoSiteiQ56A07.

Expressioni

Gene expression databases

BgeeiENSMUSG00000070304.
CleanExiMM_SCN2B.
ExpressionAtlasiQ56A07. baseline and differential.
GenevisibleiQ56A07. MM.

Interactioni

Subunit structurei

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091377.

Structurei

3D structure databases

ProteinModelPortaliQ56A07.
SMRiQ56A07. Positions 35-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 154123Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II8M. Eukaryota.
ENOG4111M25. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000118120.
HOVERGENiHBG003443.
InParanoidiQ56A07.
KOiK04846.
OMAiHGKIYLQ.
OrthoDBiEOG091G0O9E.
PhylomeDBiQ56A07.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029873. SCN2B.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF3. PTHR13869:SF3. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56A07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRDAWLPRP AFSLTGLSLF FSLVPPGRSM EVTAPTTLSV LNGSDTRLPC
60 70 80 90 100
TFNSCYTVNH KQFSLNWTYQ ECNNCTEEMF LQFRMKIINL KLERFGDRVE
110 120 130 140 150
FSGNPSKYDV SVTLKNVQLE DEGIYNCYIT NPPDRHRGHG KIYLQVLLEV
160 170 180 190 200
PPERDSTVAV IVGASVGGFL AVVILVLMVV KCVRRKKEQK LSTDDLKTEE
210
EGKMDGEGNA EDGTK
Length:215
Mass (Da):24,228
Last modified:May 10, 2005 - v1
Checksum:i38C1687665924FD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092225 mRNA. Translation: AAH92225.1.
CCDSiCCDS40606.1.
RefSeqiNP_001014761.1. NM_001014761.2.
UniGeneiMm.229373.
Mm.491371.

Genome annotation databases

EnsembliENSMUST00000093855; ENSMUSP00000091377; ENSMUSG00000070304.
ENSMUST00000170998; ENSMUSP00000126826; ENSMUSG00000070304.
GeneIDi72821.
KEGGimmu:72821.
UCSCiuc009pfg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092225 mRNA. Translation: AAH92225.1.
CCDSiCCDS40606.1.
RefSeqiNP_001014761.1. NM_001014761.2.
UniGeneiMm.229373.
Mm.491371.

3D structure databases

ProteinModelPortaliQ56A07.
SMRiQ56A07. Positions 35-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091377.

PTM databases

iPTMnetiQ56A07.
PhosphoSiteiQ56A07.

Proteomic databases

MaxQBiQ56A07.
PaxDbiQ56A07.
PRIDEiQ56A07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093855; ENSMUSP00000091377; ENSMUSG00000070304.
ENSMUST00000170998; ENSMUSP00000126826; ENSMUSG00000070304.
GeneIDi72821.
KEGGimmu:72821.
UCSCiuc009pfg.1. mouse.

Organism-specific databases

CTDi6327.
MGIiMGI:106921. Scn2b.

Phylogenomic databases

eggNOGiENOG410II8M. Eukaryota.
ENOG4111M25. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000118120.
HOVERGENiHBG003443.
InParanoidiQ56A07.
KOiK04846.
OMAiHGKIYLQ.
OrthoDBiEOG091G0O9E.
PhylomeDBiQ56A07.
TreeFamiTF331728.

Miscellaneous databases

PROiQ56A07.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070304.
CleanExiMM_SCN2B.
ExpressionAtlasiQ56A07. baseline and differential.
GenevisibleiQ56A07. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029873. SCN2B.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF3. PTHR13869:SF3. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCN2B_MOUSE
AccessioniPrimary (citable) accession number: Q56A07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.