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Protein

Transmembrane and TPR repeat-containing protein 2

Gene

Tmtc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and TPR repeat-containing protein 2
Gene namesi
Name:Tmtc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914057. Tmtc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence analysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence analysisAdd
BLAST
Transmembranei169 – 18315HelicalSequence analysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24120HelicalSequence analysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence analysisAdd
BLAST
Transmembranei400 – 42021HelicalSequence analysisAdd
BLAST
Transmembranei423 – 44321HelicalSequence analysisAdd
BLAST
Transmembranei450 – 47021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 836836Transmembrane and TPR repeat-containing protein 2PRO_0000280304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ56A06.
PaxDbiQ56A06.
PRIDEiQ56A06.

PTM databases

PhosphoSiteiQ56A06.

Expressioni

Gene expression databases

BgeeiQ56A06.
GenevisibleiQ56A06. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061919.

Structurei

3D structure databases

ProteinModelPortaliQ56A06.
SMRiQ56A06. Positions 487-830.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati460 – 49233TPR 1Add
BLAST
Repeati493 – 52634TPR 2Add
BLAST
Repeati527 – 56034TPR 3Add
BLAST
Repeati562 – 59433TPR 4Add
BLAST
Repeati606 – 63934TPR 5Add
BLAST
Repeati643 – 67634TPR 6Add
BLAST
Repeati677 – 71034TPR 7Add
BLAST
Repeati712 – 74433TPR 8Add
BLAST
Repeati746 – 77833TPR 9Add
BLAST
Repeati779 – 81234TPR 10Add
BLAST

Sequence similaritiesi

Belongs to the TMTC family.Curated
Contains 10 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQRH. Eukaryota.
ENOG410XP5Q. LUCA.
GeneTreeiENSGT00550000074327.
HOGENOMiHOG000010230.
HOVERGENiHBG054555.
InParanoidiQ56A06.
OMAiPSVDREC.
OrthoDBiEOG7BKCT0.
PhylomeDBiQ56A06.
TreeFamiTF328339.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013618. DUF1736.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08409. DUF1736. 1 hit.
PF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 9 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 9 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q56A06-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIAELVSSAL GLALYLNTLS ADFCYDDSRA IKTNQDLLPE TPWTHIFYND
60 70 80 90 100
FWGTLLTHSG SHKSYRPLCT LSFRLNHAIG GLNPWSYHLV NVLLHAAVTG
110 120 130 140 150
LFTRFSKALL GDGYWTFMAG LMFASHPIHT EAVAGIVGRA DVGASLFFLL
160 170 180 190 200
SLLCYIKHCS TRGYSARTWG WFLGTGLCAG CSMLWKEQGV TVLAVSAVYD
210 220 230 240 250
VFVFHRLKMK QILPTIYKRK NLSLFLSISL LTFWGTCLLG ARLYWMGNKP
260 270 280 290 300
PSFSNSDNPA ADSDSLLART LTFLYLPTKN LWLLLCPDTL SFDWSMDAVP
310 320 330 340 350
LLKTVCDWRN LHTVAFYSGL LLLAYCGLKN PSLEGECNGK ALTNGKQNAN
360 370 380 390 400
GHSCHSDVEY RNSEMKPSFA SKVENGIKNC VPQRTQLPST ENIVILSLSL
410 420 430 440 450
LIIPFIPATN LFFYVGFVIA ERVLYIPSMG FCLLITVGAR ALYVKVQKRF
460 470 480 490 500
LKSLVFYATA TLIVFYGVKT AIRNGDWQNE EMLYRSGIKV NPAKAWGNLG
510 520 530 540 550
NVLKSQSKIS EAESAYRNAL FYRSNMADML YNLGLLLQEN SRFAEALHYY
560 570 580 590 600
KLAIGSRPTL ASAYLNTGII LMNQGKTEEA RRTFLKCSEI PDENLKDPHA
610 620 630 640 650
HKSSVTSCLY NLGKLYHEQG RYEEALSVYR EAIQKMPRHF APQSLYNMMG
660 670 680 690 700
EAYMRLSKLP EAEHWYMESL RSKTDHIPAH LTYGKLLALT GRKSEAEKFF
710 720 730 740 750
LKAIELDPTK GNCYMHYGQF LLEESRLTEA AEMAKKAAEL DNTEFDVVFN
760 770 780 790 800
AAHMLRQASL NEAAEKYYDL AARLRPNYPA ALMNLGAILH LNGRLQKAEA
810 820 830
NYLRALQLKP DDVITQSNLR KLWNIMEKQG LKTSKT
Length:836
Mass (Da):94,176
Last modified:May 10, 2005 - v1
Checksum:i57E5A7AF66F8568A
GO
Isoform 2 (identifier: Q56A06-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     719-721: QFL → EWR
     722-836: Missing.

Note: No experimental confirmation available.
Show »
Length:721
Mass (Da):81,276
Checksum:i5BB5A78C0D833CD7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei719 – 7213QFL → EWR in isoform 2. 1 PublicationVSP_023628
Alternative sequencei722 – 836115Missing in isoform 2. 1 PublicationVSP_023629Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052344 mRNA. Translation: BAC34946.1.
BC034657 mRNA. Translation: AAH34657.1.
BC092226 mRNA. Translation: AAH92226.1.
BC138362 mRNA. Translation: AAI38363.1.
BC138363 mRNA. Translation: AAI38364.1.
CCDSiCCDS24157.1. [Q56A06-1]
RefSeqiNP_796342.2. NM_177368.4. [Q56A06-1]
UniGeneiMm.25225.

Genome annotation databases

EnsembliENSMUST00000061506; ENSMUSP00000061919; ENSMUSG00000036019. [Q56A06-1]
GeneIDi278279.
KEGGimmu:278279.
UCSCiuc007gym.1. mouse. [Q56A06-1]
uc007gyn.1. mouse. [Q56A06-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052344 mRNA. Translation: BAC34946.1.
BC034657 mRNA. Translation: AAH34657.1.
BC092226 mRNA. Translation: AAH92226.1.
BC138362 mRNA. Translation: AAI38363.1.
BC138363 mRNA. Translation: AAI38364.1.
CCDSiCCDS24157.1. [Q56A06-1]
RefSeqiNP_796342.2. NM_177368.4. [Q56A06-1]
UniGeneiMm.25225.

3D structure databases

ProteinModelPortaliQ56A06.
SMRiQ56A06. Positions 487-830.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061919.

PTM databases

PhosphoSiteiQ56A06.

Proteomic databases

MaxQBiQ56A06.
PaxDbiQ56A06.
PRIDEiQ56A06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061506; ENSMUSP00000061919; ENSMUSG00000036019. [Q56A06-1]
GeneIDi278279.
KEGGimmu:278279.
UCSCiuc007gym.1. mouse. [Q56A06-1]
uc007gyn.1. mouse. [Q56A06-2]

Organism-specific databases

CTDi160335.
MGIiMGI:1914057. Tmtc2.

Phylogenomic databases

eggNOGiENOG410IQRH. Eukaryota.
ENOG410XP5Q. LUCA.
GeneTreeiENSGT00550000074327.
HOGENOMiHOG000010230.
HOVERGENiHBG054555.
InParanoidiQ56A06.
OMAiPSVDREC.
OrthoDBiEOG7BKCT0.
PhylomeDBiQ56A06.
TreeFamiTF328339.

Miscellaneous databases

ChiTaRSiTmtc2. mouse.
NextBioi393916.
PROiQ56A06.
SOURCEiSearch...

Gene expression databases

BgeeiQ56A06.
GenevisibleiQ56A06. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013618. DUF1736.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08409. DUF1736. 1 hit.
PF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 9 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 9 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and Czech II.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiTMTC2_MOUSE
AccessioniPrimary (citable) accession number: Q56A06
Secondary accession number(s): B2RRD8, Q5U620, Q8C787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.