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Q569Z6

- TR150_MOUSE

UniProt

Q569Z6 - TR150_MOUSE

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Protein

Thyroid hormone receptor-associated protein 3

Gene

Thrap3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi549 – 5568ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoprotein binding Source: UniProtKB
  3. poly(A) RNA binding Source: Ensembl
  4. receptor activity Source: Ensembl
  5. RNA polymerase II transcription cofactor activity Source: Ensembl
  6. transcription coactivator activity Source: Ensembl

GO - Biological processi

  1. androgen receptor signaling pathway Source: Ensembl
  2. mRNA processing Source: UniProtKB-KW
  3. mRNA stabilization Source: UniProtKB
  4. nuclear-transcribed mRNA catabolic process Source: UniProtKB
  5. positive regulation of mRNA splicing, via spliceosome Source: UniProtKB
  6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  7. regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
  8. RNA splicing Source: UniProtKB-KW
  9. transcription from RNA polymerase II promoter Source: MGI
  10. transcription initiation from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

mRNA processing, mRNA splicing, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor-associated protein 3
Alternative name(s):
Thyroid hormone receptor-associated protein complex 150 kDa component
Short name:
Trap150
Gene namesi
Name:Thrap3
Synonyms:Trap150
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2442637. Thrap3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. exon-exon junction complex Source: Ensembl
  2. mediator complex Source: MGI
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 951950Thyroid hormone receptor-associated protein 3PRO_0000235980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei17 – 171Dimethylated arginineBy similarity
Modified residuei221 – 2211N6-acetyllysineBy similarity
Modified residuei233 – 2331PhosphoserineBy similarity
Modified residuei238 – 2381PhosphoserineBy similarity
Modified residuei240 – 2401PhosphoserineBy similarity
Modified residuei243 – 2431Phosphoserine3 Publications
Modified residuei248 – 2481Phosphoserine1 Publication
Modified residuei253 – 2531Phosphoserine1 Publication
Modified residuei257 – 2571PhosphoserineBy similarity
Modified residuei315 – 3151Phosphoserine1 Publication
Modified residuei320 – 3201Phosphoserine1 Publication
Modified residuei339 – 3391PhosphoserineBy similarity
Modified residuei346 – 3461N6-acetyllysine1 Publication
Modified residuei379 – 3791Phosphoserine2 Publications
Modified residuei403 – 4031PhosphoserineBy similarity
Modified residuei405 – 4051PhosphoserineBy similarity
Modified residuei452 – 4521N6-acetyllysine1 Publication
Modified residuei468 – 4681N6-acetyllysine1 Publication
Modified residuei476 – 4761N6-acetyllysine1 Publication
Modified residuei516 – 5161N6-acetyllysineBy similarity
Modified residuei524 – 5241N6-acetyllysine1 Publication
Modified residuei532 – 5321PhosphoserineBy similarity
Modified residuei555 – 5551N6-acetyllysine1 Publication
Modified residuei572 – 5721Phosphoserine3 Publications
Modified residuei619 – 6191PhosphoserineBy similarity
Modified residuei669 – 6691PhosphoserineBy similarity
Modified residuei679 – 6791Phosphoserine3 Publications
Modified residuei695 – 6951PhosphoserineBy similarity
Modified residuei808 – 8081N6-acetyllysineBy similarity
Modified residuei870 – 8701PhosphothreonineBy similarity
Modified residuei924 – 9241Phosphoserine2 Publications
Modified residuei935 – 9351Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ569Z6.
PaxDbiQ569Z6.
PRIDEiQ569Z6.

PTM databases

PhosphoSiteiQ569Z6.

Expressioni

Gene expression databases

BgeeiQ569Z6.
CleanExiMM_THRAP3.
ExpressionAtlasiQ569Z6. baseline and differential.
GenevestigatoriQ569Z6.

Interactioni

Subunit structurei

Associated with the large multiprotein complex TRAP (Mediator complex-like). Interacts with SFPQ; the interaction is dependent on SFPQ phosphorylation at 'Thr-679' and inhibits binding of SFPQ to an ESS1 exonic splicing silencer element-containing RNA. Interacts with NXF1. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Associated with spliced mRNP complexes. Interacts with HELZ2 and PPARG.1 Publication

Protein-protein interaction databases

BioGridi231014. 3 interactions.
IntActiQ569Z6. 4 interactions.
STRINGi10090.ENSMUSP00000079722.

Structurei

3D structure databases

ProteinModelPortaliQ569Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 190189Required for mRNA splicing activationBy similarityAdd
BLAST
Regioni359 – 951593Required for mRNA decay activityBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 339333Ser-richAdd
BLAST
Compositional biasi12 – 161150Arg-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG43306.
GeneTreeiENSGT00530000063211.
HOGENOMiHOG000231570.
HOVERGENiHBG054554.
InParanoidiQ569Z6.
KOiK13112.
OMAiRSTEKTE.
OrthoDBiEOG7RBZ7X.
PhylomeDBiQ569Z6.
TreeFamiTF335939.

Family and domain databases

InterProiIPR026667. THRAP3.
IPR029199. THRAP3_BCLAF1.
[Graphical view]
PANTHERiPTHR15268:SF16. PTHR15268:SF16. 1 hit.
PfamiPF15440. THRAP3_BCLAF1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q569Z6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKTNKSKSG SRSSRSRSAS RSRSRSFSKS RSRSRSVSRS RKRRLSSRSR
60 70 80 90 100
SRSYSPAHNR ERNHPRVYQN RDFRGHNRGY RRPYYFRGRN RGFYPWGQYN
110 120 130 140 150
RGGYGNYRSN WQNYRQAYSP RRGRSRSRSP KRRSPSPRSR SHSRNSDKSS
160 170 180 190 200
SDRSRRSSSS RSSSNHSRVE SSKRKSTKEK KSSSKDSRPS QAAGDNQGDE
210 220 230 240 250
AKEQTFSGGT SQDIKGSESS KPWPDATTYG AGSASRASVS DLSPRERSPA
260 270 280 290 300
LKSPLQSVVV RRRSPRPSPV PKPSPPLSNA SQMGSSMSGG AGYQSGAHQG
310 320 330 340 350
QFDHGSGSLS PSKKSPVGKS PPATGSAYGS SQKEESAASG GAAYSKRYLE
360 370 380 390 400
EQKTENGKDK EQKQTNADKE KLKEKGGFSD ADVKMKSDPF APKTDSEKPF
410 420 430 440 450
RGSQSPKRYK LRDDFEKKMA DFHKEELDEH DKDKSKGRKE PEFDDEPKFM
460 470 480 490 500
SKVIAGASKN QEEEKSGKWE SLHTGKEKQR KAEEMEDEPF TERSRKEERG
510 520 530 540 550
GSKRSESGHR GFVPEKNFRV TAYKAVQEKS SSPPPRKTSE SRDKLGSKGD
560 570 580 590 600
FSSGKSSFSI TREAQVNVRM DSFDEDLARP SGLLAQERKL CRDLVHSNKK
610 620 630 640 650
EQEFRSIFQH IQSAQSQRSP SELFAQHIVT IVHHVKEHHF GSSGMTLHER
660 670 680 690 700
FTKYLKRGNE QEAAKNKKSP EIHRRIDISP STFRKHGLTH EELKSPREPG
710 720 730 740 750
YKAEGKYKDD PVDLRLDIER RKKHKERDLK RGKSRESVDS RDSSHSRERS
760 770 780 790 800
TEKTEKTHKG SKKQKKHRRA RDRSRSSSSS SQSSHSYKAE EYPEEAEERE
810 820 830 840 850
ESTSGFDKSR LGTKDFVGPN ERGGRARGTF QFRARGRGWG RGNYSGNNNN
860 870 880 890 900
NSNNDFQKRS REEEWDPEYT PKSKKYYLHD DREGEGSDKW MGRGRGRGAF
910 920 930 940 950
PRGRGRFMFR KSSTSPKWAH DKFSGEEGEI EDDESGTENR EEKDSLQPSA

E
Length:951
Mass (Da):108,178
Last modified:May 10, 2005 - v1
Checksum:i40DF483027363B4E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC092239 mRNA. Translation: AAH92239.1.
CCDSiCCDS18645.1.
RefSeqiNP_666265.3. NM_146153.3.
XP_006503104.1. XM_006503041.1.
UniGeneiMm.236211.
Mm.29813.

Genome annotation databases

EnsembliENSMUST00000080919; ENSMUSP00000079722; ENSMUSG00000043962.
GeneIDi230753.
KEGGimmu:230753.
UCSCiuc008usv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC092239 mRNA. Translation: AAH92239.1 .
CCDSi CCDS18645.1.
RefSeqi NP_666265.3. NM_146153.3.
XP_006503104.1. XM_006503041.1.
UniGenei Mm.236211.
Mm.29813.

3D structure databases

ProteinModelPortali Q569Z6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231014. 3 interactions.
IntActi Q569Z6. 4 interactions.
STRINGi 10090.ENSMUSP00000079722.

PTM databases

PhosphoSitei Q569Z6.

Proteomic databases

MaxQBi Q569Z6.
PaxDbi Q569Z6.
PRIDEi Q569Z6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080919 ; ENSMUSP00000079722 ; ENSMUSG00000043962 .
GeneIDi 230753.
KEGGi mmu:230753.
UCSCi uc008usv.1. mouse.

Organism-specific databases

CTDi 9967.
MGIi MGI:2442637. Thrap3.

Phylogenomic databases

eggNOGi NOG43306.
GeneTreei ENSGT00530000063211.
HOGENOMi HOG000231570.
HOVERGENi HBG054554.
InParanoidi Q569Z6.
KOi K13112.
OMAi RSTEKTE.
OrthoDBi EOG7RBZ7X.
PhylomeDBi Q569Z6.
TreeFami TF335939.

Miscellaneous databases

ChiTaRSi THRAP3. mouse.
NextBioi 380111.
PROi Q569Z6.
SOURCEi Search...

Gene expression databases

Bgeei Q569Z6.
CleanExi MM_THRAP3.
ExpressionAtlasi Q569Z6. baseline and differential.
Genevestigatori Q569Z6.

Family and domain databases

InterProi IPR026667. THRAP3.
IPR029199. THRAP3_BCLAF1.
[Graphical view ]
PANTHERi PTHR15268:SF16. PTHR15268:SF16. 1 hit.
Pfami PF15440. THRAP3_BCLAF1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Head.
  2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-572, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-315; SER-320; SER-379; SER-924 AND SER-935, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243 AND SER-679, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-379; SER-572; SER-679; SER-924 AND SER-935, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-248; SER-253; SER-572 AND SER-679, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-346; LYS-452; LYS-468; LYS-476; LYS-524 AND LYS-555, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  8. Cited for: FUNCTION, INTERACTION WITH HELZ2 AND PPARG, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTR150_MOUSE
AccessioniPrimary (citable) accession number: Q569Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3