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Protein

E3 ubiquitin-protein ligase Mdm2

Gene

Mdm2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase Mdm2UniRule annotation (EC:2.3.2.27UniRule annotation)
Gene namesi
Name:Mdm2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96952 Mdm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 324RanBP2-typeInterPro annotationAdd BLAST30
Domaini434 – 475RING-typeInterPro annotationAdd BLAST42

Sequence similaritiesi

Belongs to the MDM2/MDM4 family.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGXG Eukaryota
ENOG41125MP LUCA
HOVERGENiHBG013472

Family and domain databases

Gene3Di1.10.245.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028340 Mdm2
IPR015459 MDM2_E3_ligase
IPR016495 p53_neg-reg_MDM_2/4
IPR036885 SWIB_MDM2_dom_sf
IPR003121 SWIB_MDM2_domain
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR13844:SF15 PTHR13844:SF15, 1 hit
PfamiView protein in Pfam
PF02201 SWIB, 1 hit
PF00641 zf-RanBP, 1 hit
PIRSFiPIRSF500700 MDM2, 1 hit
PIRSF006748 p53_MDM_2/4, 1 hit
SUPFAMiSSF47592 SSF47592, 2 hits
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q569X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCNTNMSVST EGAASTSQIP ASEQETLVRP KPLLLKLLKS VGAQNDTYTM
60 70 80 90 100
KEIIFYIGQY IMTKRLYDEK QQHIVYCSND LLGDVFGVPS FSVKEHRKIY
110 120 130 140 150
AMIYRNLVAV SQQDSGTSLS ESRRQPEGGS DLKDPLQAPP EEKPSSSDLI
160 170 180 190 200
SRLSTSSRRR SISETEENTD ELPGERHRKR RRSLSFDPSL GLCELREMCS
210 220 230 240 250
GGSSSSSSSE STETPSHQDL DDGVSEHSGD CLDQDSVSDQ FSVEFEVESL
260 270 280 290 300
DSEDYSLSDE GHELSDEDDE VYRVTVYQTG ESDTDSFEGD PEISLADYWK
310 320 330 340 350
CTSCNEMNPP LPSHCKRCWT LRENWLPDDK GKDKLEISEK AKLENSAQAE
360 370 380 390 400
EGLDVPDGKK LTENDAKEPC AEEDSEEKAE QTPLSQESDD YSQPSTSSSI
410 420 430 440 450
VYSSQESVKE LKEETQDKDE SVESSFSLNA IEPCVICQGR PKNGCIVHGK
460 470 480
TGHLMSCFTC AKKLKKRNKP CPVCRQPIQM IVLTYFN
Length:487
Mass (Da):54,398
Last modified:May 10, 2005 - v1
Checksum:i456E7EE0329EB9FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092270 mRNA Translation: AAH92270.1
UniGeneiMm.22670
Mm.447669

Similar proteinsi

Entry informationi

Entry nameiQ569X0_MOUSE
AccessioniPrimary (citable) accession number: Q569X0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health