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Q569X0

- Q569X0_MOUSE

UniProt

Q569X0 - Q569X0_MOUSE

Protein
Submitted name:

Mdm2 protein

Gene

Mdm2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. p53 binding Source: MGI
    2. protein binding Source: MGI
    3. ubiquitin-protein transferase activity Source: MGI
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. negative regulation of apoptotic process Source: InterPro
    2. negative regulation of cell cycle arrest Source: InterPro
    3. negative regulation of transcription from RNA polymerase II promoter Source: InterPro
    4. positive regulation of cell cycle Source: MGI
    5. protein catabolic process Source: MGI
    6. protein ubiquitination Source: MGI
    7. traversing start control point of mitotic cell cycle Source: MGI

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Mdm2 proteinImported
    Gene namesi
    Name:Mdm2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:96952. Mdm2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleolus Source: MGI
    3. nucleus Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ569X0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000020408.

    Structurei

    3D structure databases

    ProteinModelPortaliQ569X0.
    SMRiQ569X0. Positions 1-118, 286-331, 424-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Zinc-fingerUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG013472.
    InParanoidiQ569X0.

    Family and domain databases

    Gene3Di1.10.245.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR028340. Mdm2.
    IPR015459. MDM2_E3_ligase.
    IPR016495. p53_neg-reg_MDM_2/4.
    IPR003121. SWIB_MDM2_domain.
    IPR001876. Znf_RanBP2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PANTHERiPTHR10360:SF11. PTHR10360:SF11. 1 hit.
    PfamiPF02201. SWIB. 1 hit.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500700. MDM2. 1 hit.
    PIRSF006748. p53_MDM_2/4. 1 hit.
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF47592. SSF47592. 2 hits.
    PROSITEiPS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q569X0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCNTNMSVST EGAASTSQIP ASEQETLVRP KPLLLKLLKS VGAQNDTYTM    50
    KEIIFYIGQY IMTKRLYDEK QQHIVYCSND LLGDVFGVPS FSVKEHRKIY 100
    AMIYRNLVAV SQQDSGTSLS ESRRQPEGGS DLKDPLQAPP EEKPSSSDLI 150
    SRLSTSSRRR SISETEENTD ELPGERHRKR RRSLSFDPSL GLCELREMCS 200
    GGSSSSSSSE STETPSHQDL DDGVSEHSGD CLDQDSVSDQ FSVEFEVESL 250
    DSEDYSLSDE GHELSDEDDE VYRVTVYQTG ESDTDSFEGD PEISLADYWK 300
    CTSCNEMNPP LPSHCKRCWT LRENWLPDDK GKDKLEISEK AKLENSAQAE 350
    EGLDVPDGKK LTENDAKEPC AEEDSEEKAE QTPLSQESDD YSQPSTSSSI 400
    VYSSQESVKE LKEETQDKDE SVESSFSLNA IEPCVICQGR PKNGCIVHGK 450
    TGHLMSCFTC AKKLKKRNKP CPVCRQPIQM IVLTYFN 487
    Length:487
    Mass (Da):54,398
    Last modified:May 10, 2005 - v1
    Checksum:i456E7EE0329EB9FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC092270 mRNA. Translation: AAH92270.1.
    UniGeneiMm.22670.
    Mm.447669.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC092270 mRNA. Translation: AAH92270.1 .
    UniGenei Mm.22670.
    Mm.447669.

    3D structure databases

    ProteinModelPortali Q569X0.
    SMRi Q569X0. Positions 1-118, 286-331, 424-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000020408.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:96952. Mdm2.

    Phylogenomic databases

    HOVERGENi HBG013472.
    InParanoidi Q569X0.

    Miscellaneous databases

    ChiTaRSi MDM2. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q569X0.

    Family and domain databases

    Gene3Di 1.10.245.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR028340. Mdm2.
    IPR015459. MDM2_E3_ligase.
    IPR016495. p53_neg-reg_MDM_2/4.
    IPR003121. SWIB_MDM2_domain.
    IPR001876. Znf_RanBP2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    PANTHERi PTHR10360:SF11. PTHR10360:SF11. 1 hit.
    Pfami PF02201. SWIB. 1 hit.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500700. MDM2. 1 hit.
    PIRSF006748. p53_MDM_2/4. 1 hit.
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47592. SSF47592. 2 hits.
    PROSITEi PS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CZECH IIImported.
      Tissue: Mammary tumor metastatized to lung. Tumor arose spontaneouslyImported.

    Entry informationi

    Entry nameiQ569X0_MOUSE
    AccessioniPrimary (citable) accession number: Q569X0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)