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Q569L8

- CENPJ_MOUSE

UniProt

Q569L8 - CENPJ_MOUSE

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Protein

Centromere protein J

Gene

Cenpj

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome (By similarity).By similarity

GO - Biological processi

  1. centriole replication Source: Ensembl
  2. microtubule polymerization Source: Ensembl
  3. regulation of centriole replication Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196635. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein J
Short name:
CENP-J
Gene namesi
Name:Cenpj
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:2684927. Cenpj.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
Note: Localized within the center of microtubule asters. During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles (By similarity).By similarity

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13441344Centromere protein JPRO_0000286053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei577 – 5771Phosphoserine; by PLK2By similarity
Modified residuei583 – 5831Phosphoserine; by PLK2By similarity
Modified residuei748 – 7481PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation at Ser-577 and Ser-583 by PLK2 is required for procentriole formation and centriole elongation. Phosphorylation by PLK2 oscillates during the cell cycle: it increases at G1/S transition and decreases during the exit from mitosis. Phosphorylation at Ser-583 is also mediated by PLK4 but is not a critical step in PLK4 function in procentriole assembly.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ569L8.
PRIDEiQ569L8.

PTM databases

PhosphoSiteiQ569L8.

Expressioni

Gene expression databases

BgeeiQ569L8.
CleanExiMM_CENPJ.
GenevestigatoriQ569L8.

Interactioni

Subunit structurei

Part of a ternary complex composed of SASS6, CENPJ and CEP350. Associated with the gamma-tubulin complex. Interacts with the head domain of EPB41. Interacts with LYST (By similarity). Interacts with CEP152 (via C-terminus) (By similarity).By similarity

Protein-protein interaction databases

BioGridi230108. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ569L8.
SMRiQ569L8. Positions 1173-1327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP10 family.Curated

Phylogenomic databases

eggNOGiNOG83204.
GeneTreeiENSGT00530000063927.
HOGENOMiHOG000111541.
HOVERGENiHBG050894.
InParanoidiQ569L8.
KOiK11502.
OMAiDSPQVCD.
OrthoDBiEOG77DJ60.
TreeFamiTF343156.

Family and domain databases

InterProiIPR009852. Tcp10_C_dom.
IPR026581. TCP10_fam.
[Graphical view]
PANTHERiPTHR10331. PTHR10331. 1 hit.
PfamiPF07202. Tcp10_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q569L8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLMPTSSEL NSGQNFLTQW MTSPSRAGVI LNRGFPILEA DDKQAATNVS
60 70 80 90 100
TSFPAKATHF SNSFSISSEE DSFHEEQKLE AGGPYKPWSE NPEAPPVFPS
110 120 130 140 150
VRKEPIASRQ DAPGCQEDNN NDLTPHLESE FKEVANKNPL FKKLEQLKEI
160 170 180 190 200
QQKKQEQLKR QQLEQLQRLM EEQEKLLTMV SAQHAFPGTL LPDDQSQKHR
210 220 230 240 250
SPGDLTLPPH SYSNPTQENS CASNVLPDEQ SNFCRATQDS VLTSKNASDL
260 270 280 290 300
FYESQYQEAH VKRNDLKEES PAHPSGEGAL PRWEKKMGRS QEGKDVNLQK
310 320 330 340 350
CGDSSEVVNI DERPIKAAVR EKQQTFEDYL EEQIQLEERE LRQKQLQEAE
360 370 380 390 400
GPLLAKTKPK QPFLKRGEGL ARFTNAKSKF QKGKESKLAS TQSPSEDQPG
410 420 430 440 450
SKVDRQHLQR KTALINKDLC AETPTVKKDS KARPKAGFAS LRQKPKVTKT
460 470 480 490 500
NMRESLSPPG LKVQTGKKRD GQFRHQVKGE RNAHASNKEN VPACIKPWDA
510 520 530 540 550
GCKMWSKTQG RERLPLSTGP VGCVVSRSPI RETDRETESS LDFSLQKKLE
560 570 580 590 600
IWEREKEKEN LELDEFLFLE RAADEISFSS NSSFVLRILE RDQQICDGHR
610 620 630 640 650
LSSTPVKAVQ QREAQQADPR GQSNCSEIPR YGVAHENESE CEAMLLSWGS
660 670 680 690 700
GSPDGLRELS CKRSMKAFQT STSEIQSQWD ARDDGVANSD SSTESEEQHD
710 720 730 740 750
ITIKPSTEVG DRVFSNREDS PQVCDAKGPI RDTGAQEDKW RDADLDLSDK
760 770 780 790 800
ECSSDESVIV ESLNNKVLEP LRLPSSQAGS KIDFDDERSW TDLEENPYEH
810 820 830 840 850
GVIHREEAIY GTPQTQCHSK SEGCVLDKTI KRKIAPVKKG EDFKCDRRIS
860 870 880 890 900
PPPPSDLMVK FFPSLKPKPK LDSHLENESK LNLSQDQPPE FMVCFIGDSV
910 920 930 940 950
RSQVLREKVT ELESEIEKFK AENTSLAKLR IERESALEKL RKEIADFEQQ
960 970 980 990 1000
KARELARIEE YRKEETRKLQ KERKVFEKYT AAARTFPDKK EREEIQALKQ
1010 1020 1030 1040 1050
QIADLQEDLK RKETKWSSTQ SRLRSQIEML VKENTDLREE IKVMERFRLD
1060 1070 1080 1090 1100
AWKRAEAMEN SPKACQYMMA TKKDESMNSS FQFQKSHVSS GVQVEKYKKK
1110 1120 1130 1140 1150
YLPAQGNLSR RIKSAPPRDL GSSDKGQAAL PREPLQQVNF PDLEYKNKEE
1160 1170 1180 1190 1200
KEEEIQGEIS HPDGKVEKIY KNGRRVVLFP NGTRKEVSAD GKSVTVTFFN
1210 1220 1230 1240 1250
GDVKQVMPDE RVVYYYAAAQ TTHTTYPEGL EVLHFSSGQI EKHFPDGRKE
1260 1270 1280 1290 1300
ITFPDQTIKT LFADGQEESI FPDGTIVRVQ RDGNKIIEFN NGQRELHTAQ
1310 1320 1330 1340
FKRREYPDGT VKTVYANGHQ ETKYTSGRVR VKDKDGNVLM DTEM
Length:1,344
Mass (Da):153,079
Last modified:July 27, 2011 - v2
Checksum:i0C7596B79161C2C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti716 – 7161N → S in AAH92399. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC154837 Genomic DNA. No translation available.
BC092399 mRNA. Translation: AAH92399.1.
CCDSiCCDS27150.1.
RefSeqiNP_001014996.2. NM_001014996.2.
UniGeneiMm.212525.

Genome annotation databases

EnsembliENSMUST00000065302; ENSMUSP00000065949; ENSMUSG00000064128.
GeneIDi219103.
KEGGimmu:219103.
UCSCiuc007ucb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC154837 Genomic DNA. No translation available.
BC092399 mRNA. Translation: AAH92399.1 .
CCDSi CCDS27150.1.
RefSeqi NP_001014996.2. NM_001014996.2.
UniGenei Mm.212525.

3D structure databases

ProteinModelPortali Q569L8.
SMRi Q569L8. Positions 1173-1327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 230108. 1 interaction.

PTM databases

PhosphoSitei Q569L8.

Proteomic databases

PaxDbi Q569L8.
PRIDEi Q569L8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065302 ; ENSMUSP00000065949 ; ENSMUSG00000064128 .
GeneIDi 219103.
KEGGi mmu:219103.
UCSCi uc007ucb.2. mouse.

Organism-specific databases

CTDi 55835.
MGIi MGI:2684927. Cenpj.

Phylogenomic databases

eggNOGi NOG83204.
GeneTreei ENSGT00530000063927.
HOGENOMi HOG000111541.
HOVERGENi HBG050894.
InParanoidi Q569L8.
KOi K11502.
OMAi DSPQVCD.
OrthoDBi EOG77DJ60.
TreeFami TF343156.

Enzyme and pathway databases

Reactomei REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

NextBioi 376568.
PROi Q569L8.
SOURCEi Search...

Gene expression databases

Bgeei Q569L8.
CleanExi MM_CENPJ.
Genevestigatori Q569L8.

Family and domain databases

InterProi IPR009852. Tcp10_C_dom.
IPR026581. TCP10_fam.
[Graphical view ]
PANTHERi PTHR10331. PTHR10331. 1 hit.
Pfami PF07202. Tcp10_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiCENPJ_MOUSE
AccessioniPrimary (citable) accession number: Q569L8
Secondary accession number(s): E9QLP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3