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Q569L8

- CENPJ_MOUSE

UniProt

Q569L8 - CENPJ_MOUSE

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Protein

Centromere protein J

Gene
Cenpj
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. centriole replication Source: Ensembl
  2. microtubule polymerization Source: Ensembl
  3. regulation of centriole replication Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196635. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein J
Short name:
CENP-J
Gene namesi
Name:Cenpj
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:2684927. Cenpj.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
Note: Localized within the center of microtubule asters. During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles By similarity.

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13441344Centromere protein JPRO_0000286053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei577 – 5771Phosphoserine; by PLK2 By similarity
Modified residuei583 – 5831Phosphoserine; by PLK2 By similarity
Modified residuei748 – 7481Phosphoserine By similarity

Post-translational modificationi

Phosphorylation at Ser-577 and Ser-583 by PLK2 is required for procentriole formation and centriole elongation. Phosphorylation by PLK2 oscillates during the cell cycle: it increases at G1/S transition and decreases during the exit from mitosis. Phosphorylation at Ser-583 is also mediated by PLK4 but is not a critical step in PLK4 function in procentriole assembly.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ569L8.
PRIDEiQ569L8.

PTM databases

PhosphoSiteiQ569L8.

Expressioni

Gene expression databases

BgeeiQ569L8.
CleanExiMM_CENPJ.
GenevestigatoriQ569L8.

Interactioni

Subunit structurei

Part of a ternary complex composed of SASS6, CENPJ and CEP350. Associated with the gamma-tubulin complex. Interacts with the head domain of EPB41. Interacts with LYST By similarity. Interacts with CEP152 (via C-terminus) By similarity.

Protein-protein interaction databases

BioGridi230108. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ569L8.
SMRiQ569L8. Positions 1173-1327.

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP10 family.

Phylogenomic databases

eggNOGiNOG83204.
GeneTreeiENSGT00530000063927.
HOGENOMiHOG000111541.
HOVERGENiHBG050894.
InParanoidiQ569L8.
KOiK11502.
OMAiDSPQVCD.
OrthoDBiEOG77DJ60.
TreeFamiTF343156.

Family and domain databases

InterProiIPR009852. Tcp10_C_dom.
IPR026581. TCP10_fam.
[Graphical view]
PANTHERiPTHR10331. PTHR10331. 1 hit.
PfamiPF07202. Tcp10_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q569L8-1 [UniParc]FASTAAdd to Basket

« Hide

MFLMPTSSEL NSGQNFLTQW MTSPSRAGVI LNRGFPILEA DDKQAATNVS     50
TSFPAKATHF SNSFSISSEE DSFHEEQKLE AGGPYKPWSE NPEAPPVFPS 100
VRKEPIASRQ DAPGCQEDNN NDLTPHLESE FKEVANKNPL FKKLEQLKEI 150
QQKKQEQLKR QQLEQLQRLM EEQEKLLTMV SAQHAFPGTL LPDDQSQKHR 200
SPGDLTLPPH SYSNPTQENS CASNVLPDEQ SNFCRATQDS VLTSKNASDL 250
FYESQYQEAH VKRNDLKEES PAHPSGEGAL PRWEKKMGRS QEGKDVNLQK 300
CGDSSEVVNI DERPIKAAVR EKQQTFEDYL EEQIQLEERE LRQKQLQEAE 350
GPLLAKTKPK QPFLKRGEGL ARFTNAKSKF QKGKESKLAS TQSPSEDQPG 400
SKVDRQHLQR KTALINKDLC AETPTVKKDS KARPKAGFAS LRQKPKVTKT 450
NMRESLSPPG LKVQTGKKRD GQFRHQVKGE RNAHASNKEN VPACIKPWDA 500
GCKMWSKTQG RERLPLSTGP VGCVVSRSPI RETDRETESS LDFSLQKKLE 550
IWEREKEKEN LELDEFLFLE RAADEISFSS NSSFVLRILE RDQQICDGHR 600
LSSTPVKAVQ QREAQQADPR GQSNCSEIPR YGVAHENESE CEAMLLSWGS 650
GSPDGLRELS CKRSMKAFQT STSEIQSQWD ARDDGVANSD SSTESEEQHD 700
ITIKPSTEVG DRVFSNREDS PQVCDAKGPI RDTGAQEDKW RDADLDLSDK 750
ECSSDESVIV ESLNNKVLEP LRLPSSQAGS KIDFDDERSW TDLEENPYEH 800
GVIHREEAIY GTPQTQCHSK SEGCVLDKTI KRKIAPVKKG EDFKCDRRIS 850
PPPPSDLMVK FFPSLKPKPK LDSHLENESK LNLSQDQPPE FMVCFIGDSV 900
RSQVLREKVT ELESEIEKFK AENTSLAKLR IERESALEKL RKEIADFEQQ 950
KARELARIEE YRKEETRKLQ KERKVFEKYT AAARTFPDKK EREEIQALKQ 1000
QIADLQEDLK RKETKWSSTQ SRLRSQIEML VKENTDLREE IKVMERFRLD 1050
AWKRAEAMEN SPKACQYMMA TKKDESMNSS FQFQKSHVSS GVQVEKYKKK 1100
YLPAQGNLSR RIKSAPPRDL GSSDKGQAAL PREPLQQVNF PDLEYKNKEE 1150
KEEEIQGEIS HPDGKVEKIY KNGRRVVLFP NGTRKEVSAD GKSVTVTFFN 1200
GDVKQVMPDE RVVYYYAAAQ TTHTTYPEGL EVLHFSSGQI EKHFPDGRKE 1250
ITFPDQTIKT LFADGQEESI FPDGTIVRVQ RDGNKIIEFN NGQRELHTAQ 1300
FKRREYPDGT VKTVYANGHQ ETKYTSGRVR VKDKDGNVLM DTEM 1344
Length:1,344
Mass (Da):153,079
Last modified:July 27, 2011 - v2
Checksum:i0C7596B79161C2C6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti716 – 7161N → S in AAH92399. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC154837 Genomic DNA. No translation available.
BC092399 mRNA. Translation: AAH92399.1.
CCDSiCCDS27150.1.
RefSeqiNP_001014996.2. NM_001014996.2.
UniGeneiMm.212525.

Genome annotation databases

EnsembliENSMUST00000065302; ENSMUSP00000065949; ENSMUSG00000064128.
GeneIDi219103.
KEGGimmu:219103.
UCSCiuc007ucb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC154837 Genomic DNA. No translation available.
BC092399 mRNA. Translation: AAH92399.1 .
CCDSi CCDS27150.1.
RefSeqi NP_001014996.2. NM_001014996.2.
UniGenei Mm.212525.

3D structure databases

ProteinModelPortali Q569L8.
SMRi Q569L8. Positions 1173-1327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 230108. 1 interaction.

PTM databases

PhosphoSitei Q569L8.

Proteomic databases

PaxDbi Q569L8.
PRIDEi Q569L8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065302 ; ENSMUSP00000065949 ; ENSMUSG00000064128 .
GeneIDi 219103.
KEGGi mmu:219103.
UCSCi uc007ucb.2. mouse.

Organism-specific databases

CTDi 55835.
MGIi MGI:2684927. Cenpj.

Phylogenomic databases

eggNOGi NOG83204.
GeneTreei ENSGT00530000063927.
HOGENOMi HOG000111541.
HOVERGENi HBG050894.
InParanoidi Q569L8.
KOi K11502.
OMAi DSPQVCD.
OrthoDBi EOG77DJ60.
TreeFami TF343156.

Enzyme and pathway databases

Reactomei REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

NextBioi 376568.
PROi Q569L8.
SOURCEi Search...

Gene expression databases

Bgeei Q569L8.
CleanExi MM_CENPJ.
Genevestigatori Q569L8.

Family and domain databases

InterProi IPR009852. Tcp10_C_dom.
IPR026581. TCP10_fam.
[Graphical view ]
PANTHERi PTHR10331. PTHR10331. 1 hit.
Pfami PF07202. Tcp10_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiCENPJ_MOUSE
AccessioniPrimary (citable) accession number: Q569L8
Secondary accession number(s): E9QLP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi