Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil domain-containing protein 157

Gene

CCDC157

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 157
Gene namesi
Name:CCDC157
Synonyms:KIAA1656
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:33854. CCDC157.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717678.

Polymorphism and mutation databases

BioMutaiCCDC157.
DMDMi296439417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 752752Coiled-coil domain-containing protein 157PRO_0000319420Add
BLAST

Proteomic databases

EPDiQ569K6.
MaxQBiQ569K6.
PaxDbiQ569K6.
PRIDEiQ569K6.

PTM databases

PhosphoSiteiQ569K6.

Expressioni

Gene expression databases

BgeeiQ569K6.
ExpressionAtlasiQ569K6. baseline and differential.

Organism-specific databases

HPAiHPA042943.

Interactioni

Protein-protein interaction databases

BioGridi139247. 1 interaction.
STRINGi9606.ENSP00000343087.

Structurei

3D structure databases

ProteinModelPortaliQ569K6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili276 – 544269Sequence analysisAdd
BLAST
Coiled coili579 – 61537Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKQF. Eukaryota.
ENOG410Z8T2. LUCA.
GeneTreeiENSGT00390000013684.
HOGENOMiHOG000074196.
InParanoidiQ569K6.
OMAiLPQTCQE.
OrthoDBiEOG7WHH93.
PhylomeDBiQ569K6.
TreeFamiTF334443.

Sequencei

Sequence statusi: Complete.

Q569K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHLLGSQAC MESLRTDLTD LQGAIVDVFS RAGPVRFPSW KFPDRMACDL
60 70 80 90 100
DMVALLEHYD HVPGDPEFTQ LSHAVLLELV IDRLLLLLQS CMSYLENLGS
110 120 130 140 150
EQMMPPAQAA GPCMSVGLTV RRFWDSLLRL GTLHQQPLPQ KGANQRETPT
160 170 180 190 200
SKPTTKGEPA RSPEYLTTKL IKPSSPVLGL PQTCQEPESI PVRASLQFPA
210 220 230 240 250
TTFKNTRSVH SQTIETALVP CDACASVQGS LQKVGKVVIS LCQSQNLPSS
260 270 280 290 300
LGQFQQLVQD SMGLRPLPAA TVGRWAAEQR KDLTRLSKHV EALRAQLEEA
310 320 330 340 350
EGQKDGLRKQ AGKLEQALKQ EQGARRRQAE EDEQCLSEWE HDKQQLLTET
360 370 380 390 400
SDLKTKMATL ERELKQQRES TQAVEAKAQQ LQEEGERRAA AERQVQQLEE
410 420 430 440 450
QVQQLEAQVQ LLVGRLEGAG QQVCWASTEL DKEKARVDSM VRHQESLQAK
460 470 480 490 500
QRALLKQLDS LDQEREELRG SLDEAEAQRA RVEEQLQSER EQGQCQLRAQ
510 520 530 540 550
QELLQSLQRE KQGLEQATTD LRLTILELER ELEELKERER LLVAFPDLHR
560 570 580 590 600
PTETQIHGGR SSSVESQITC PTDSGNVTDH MERQVQSNDI RIRVLQEENG
610 620 630 640 650
RLQSMLSKIR EVAQQGGLKL IPQDRLWSPS SKGTQGATPP VQAKSTSPGP
660 670 680 690 700
LGRQHLPSSR TGRTLLGQPC TSPPRQPCTS PPRQPCTSPP RQPCTSPSRQ
710 720 730 740 750
PCSQPSKSLL EGVTHLDTCT QNPIKVLVRL RKRLSPGRGQ ASSAHQPQER

PM
Length:752
Mass (Da):83,941
Last modified:May 18, 2010 - v3
Checksum:i4652B5B0F26A9BCC
GO

Sequence cautioni

The sequence AAH92419.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB33326.1 differs from that shown.Intron retention. This sequence is incomplete at the 5'- and 3'-ends and extensively differs from that shown due to multiple introns.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161T → A in AAH92419 (PubMed:15489334).Curated
Sequence conflicti16 – 161T → A in AAI19800 (PubMed:15489334).Curated
Sequence conflicti16 – 161T → A in AAI27256 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511D → N.
Corresponds to variant rs740223 [ dbSNP | Ensembl ].
VAR_060124
Natural varianti191 – 1911P → L.
Corresponds to variant rs12167903 [ dbSNP | Ensembl ].
VAR_038999
Natural varianti587 – 5871S → A.
Corresponds to variant rs2015035 [ dbSNP | Ensembl ].
VAR_039000

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004997 Genomic DNA. No translation available.
BC092419 mRNA. Translation: AAH92419.1. Different initiation.
BC119799 mRNA. Translation: AAI19800.1.
BC127255 mRNA. Translation: AAI27256.1.
AB051443 mRNA. Translation: BAB33326.1. Sequence problems.
CCDSiCCDS33632.2.
RefSeqiNP_001017437.2. NM_001017437.3.
NP_001305263.1. NM_001318334.1.
UniGeneiHs.505597.
Hs.614837.

Genome annotation databases

EnsembliENST00000338306; ENSP00000343087; ENSG00000187860.
ENST00000405659; ENSP00000385357; ENSG00000187860.
GeneIDi550631.
KEGGihsa:550631.
UCSCiuc011aku.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004997 Genomic DNA. No translation available.
BC092419 mRNA. Translation: AAH92419.1. Different initiation.
BC119799 mRNA. Translation: AAI19800.1.
BC127255 mRNA. Translation: AAI27256.1.
AB051443 mRNA. Translation: BAB33326.1. Sequence problems.
CCDSiCCDS33632.2.
RefSeqiNP_001017437.2. NM_001017437.3.
NP_001305263.1. NM_001318334.1.
UniGeneiHs.505597.
Hs.614837.

3D structure databases

ProteinModelPortaliQ569K6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi139247. 1 interaction.
STRINGi9606.ENSP00000343087.

PTM databases

PhosphoSiteiQ569K6.

Polymorphism and mutation databases

BioMutaiCCDC157.
DMDMi296439417.

Proteomic databases

EPDiQ569K6.
MaxQBiQ569K6.
PaxDbiQ569K6.
PRIDEiQ569K6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338306; ENSP00000343087; ENSG00000187860.
ENST00000405659; ENSP00000385357; ENSG00000187860.
GeneIDi550631.
KEGGihsa:550631.
UCSCiuc011aku.3. human.

Organism-specific databases

CTDi550631.
GeneCardsiCCDC157.
HGNCiHGNC:33854. CCDC157.
HPAiHPA042943.
neXtProtiNX_Q569K6.
PharmGKBiPA164717678.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKQF. Eukaryota.
ENOG410Z8T2. LUCA.
GeneTreeiENSGT00390000013684.
HOGENOMiHOG000074196.
InParanoidiQ569K6.
OMAiLPQTCQE.
OrthoDBiEOG7WHH93.
PhylomeDBiQ569K6.
TreeFamiTF334443.

Miscellaneous databases

GenomeRNAii550631.
NextBioi112328.
PROiQ569K6.

Gene expression databases

BgeeiQ569K6.
ExpressionAtlasiQ569K6. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping."
    Hirosawa M., Nagase T., Murahashi Y., Kikuno R., Ohara O.
    DNA Res. 8:1-9(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-140.
    Tissue: Brain.

Entry informationi

Entry nameiCC157_HUMAN
AccessioniPrimary (citable) accession number: Q569K6
Secondary accession number(s): Q0VD76, Q9BYA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.