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Protein

Zinc finger protein 385B

Gene

ZNF385B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in p53/TP53-mediated apoptosis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 6431Matrin-type 1Add
BLAST
Zinc fingeri157 – 18731Matrin-type 2Add
BLAST
Zinc fingeri282 – 31635Matrin-type 3Add
BLAST
Zinc fingeri348 – 37831Matrin-type 4Add
BLAST

GO - Molecular functioni

  • p53 binding Source: UniProtKB
  • RNA binding Source: GO_Central
  • zinc ion binding Source: InterPro

GO - Biological processi

  • intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 385B
Alternative name(s):
Zinc finger protein 533
Gene namesi
Name:ZNF385B
Synonyms:ZNF533
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26332. ZNF385B.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410114.

Polymorphism and mutation databases

BioMutaiZNF385B.
DMDMi74741028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Zinc finger protein 385BPRO_0000191812Add
BLAST

Proteomic databases

PaxDbiQ569K4.
PRIDEiQ569K4.

PTM databases

iPTMnetiQ569K4.
PhosphoSiteiQ569K4.

Expressioni

Tissue specificityi

Detected in germinal center of lymph node (at protein level). Expressed in spleen, lymph node and tonsil.1 Publication

Gene expression databases

BgeeiQ569K4.
CleanExiHS_ZNF385B.
ExpressionAtlasiQ569K4. baseline and differential.
GenevisibleiQ569K4. HS.

Interactioni

Subunit structurei

Interacts with p53/TP53; the interaction is direct.1 Publication

GO - Molecular functioni

  • p53 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi127344. 2 interactions.
STRINGi9606.ENSP00000386845.

Structurei

3D structure databases

ProteinModelPortaliQ569K4.
SMRiQ569K4. Positions 345-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9393Required for induction of apoptosisAdd
BLAST
Regioni94 – 471378Interaction with p53/TP53Add
BLAST

Sequence similaritiesi

Contains 4 matrin-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 6431Matrin-type 1Add
BLAST
Zinc fingeri157 – 18731Matrin-type 2Add
BLAST
Zinc fingeri282 – 31635Matrin-type 3Add
BLAST
Zinc fingeri348 – 37831Matrin-type 4Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHAD. Eukaryota.
ENOG410Y1ZH. LUCA.
GeneTreeiENSGT00390000002371.
HOGENOMiHOG000231865.
HOVERGENiHBG054524.
InParanoidiQ569K4.
OMAiTGNNSDK.
OrthoDBiEOG7XPZ67.
PhylomeDBiQ569K4.
TreeFamiTF326622.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q569K4-1) [UniParc]FASTAAdd to basket

Also known as: IF-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNMANFLRGF EEKGIKNDRP EDQLSKEKKK ILFSFCEVCN IQLNSAAQAQ
60 70 80 90 100
VHSNGKSHRK RVKQLSDGQP PPPAQASPSS NSSTGSTCHT TTLPALVRTP
110 120 130 140 150
TLMMQPSLDI KPFMSFPVDS SSAVGLFPNF NTMDPVQKAV INHTFGVSIP
160 170 180 190 200
PKKKQVISCN VCQLRFNSDS QAEAHYKGSK HAKKVKALDA TKNKPKMVPS
210 220 230 240 250
KDSAKANPSC SITPITGNNS DKSEDKGKLK ASSSSQPSSS ESGSFLLKSG
260 270 280 290 300
TTPLPPGAAT SPSKSTNGAP GTVVESEEEK AKKLLYCSLC KVAVNSLSQL
310 320 330 340 350
EAHNTGSKHK TMVEARNGAG PIKSYPRPGS RLKMQNGSKG SGLQNKTFHC
360 370 380 390 400
EICDVHVNSE IQLKQHISSR RHKDRVAGKP LKPKYSPYNK LQRSPSILAA
410 420 430 440 450
KLAFQKDMMK PLAPAFLSSP LAAAAAVSSA LSLPPRPSAS LFQAPAIPPA
460 470
LLRPGHGPIR ATPASILFAP Y
Length:471
Mass (Da):50,407
Last modified:May 10, 2005 - v1
Checksum:i052813B99B908515
GO
Isoform 2 (identifier: Q569K4-2) [UniParc]FASTAAdd to basket

Also known as: IF-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.
     77-84: SPSSNSST → MWSGLPSR

Note: Major isoform in tonsil.
Show »
Length:395
Mass (Da):42,026
Checksum:i381EC071BE954735
GO
Isoform 3 (identifier: Q569K4-3) [UniParc]FASTAAdd to basket

Also known as: IF-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Note: Major isoform in lymph node.
Show »
Length:369
Mass (Da):39,260
Checksum:iC46C768667FA500F
GO
Isoform 4 (identifier: Q569K4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.
     366-368: HIS → PKA
     369-471: Missing.

Note: No experimental confirmation available.
Show »
Length:172
Mass (Da):17,957
Checksum:i9F108157F234129F
GO
Isoform 5 (identifier: Q569K4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRYSLSPDNHLEDGIM
     386-406: SPYNKLQRSPSILAAKLAFQK → TPCKVIGLLPKPLPPANRQLS
     407-471: Missing.

Note: No experimental confirmation available.
Show »
Length:421
Mass (Da):45,476
Checksum:i4C83553AFEC24036
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2541L → P in BAB71629 (PubMed:14702039).Curated
Sequence conflicti415 – 4151A → S in BAC04870 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421S → G.
Corresponds to variant rs2271761 [ dbSNP | Ensembl ].
VAR_053765

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 196196Missing in isoform 4. 1 PublicationVSP_015972Add
BLAST
Alternative sequencei1 – 102102Missing in isoform 3. 2 PublicationsVSP_015973Add
BLAST
Alternative sequencei1 – 7676Missing in isoform 2. 1 PublicationVSP_015974Add
BLAST
Alternative sequencei1 – 11M → MRYSLSPDNHLEDGIM in isoform 5. 1 PublicationVSP_015975
Alternative sequencei77 – 848SPSSNSST → MWSGLPSR in isoform 2. 1 PublicationVSP_015976
Alternative sequencei366 – 3683HIS → PKA in isoform 4. 1 PublicationVSP_015977
Alternative sequencei369 – 471103Missing in isoform 4. 1 PublicationVSP_015978Add
BLAST
Alternative sequencei386 – 40621SPYNK…LAFQK → TPCKVIGLLPKPLPPANRQL S in isoform 5. 1 PublicationVSP_015979Add
BLAST
Alternative sequencei407 – 47165Missing in isoform 5. 1 PublicationVSP_015980Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057999 mRNA. Translation: BAB71629.1.
AK096822 mRNA. Translation: BAC04870.1.
AK131432 mRNA. Translation: BAD18578.1.
BC038422 mRNA. Translation: AAH38422.1.
BC048123 mRNA. Translation: AAH48123.1.
BC092423 mRNA. Translation: AAH92423.1.
CCDSiCCDS33339.1. [Q569K4-1]
CCDS46463.1. [Q569K4-2]
CCDS46464.1. [Q569K4-3]
RefSeqiNP_001106868.1. NM_001113397.1. [Q569K4-2]
NP_001106869.1. NM_001113398.1. [Q569K4-3]
NP_001269654.1. NM_001282725.1. [Q569K4-3]
NP_689733.3. NM_152520.4. [Q569K4-1]
UniGeneiHs.655005.

Genome annotation databases

EnsembliENST00000336917; ENSP00000338225; ENSG00000144331. [Q569K4-3]
ENST00000409343; ENSP00000386379; ENSG00000144331. [Q569K4-2]
ENST00000409692; ENSP00000386507; ENSG00000144331. [Q569K4-3]
ENST00000410066; ENSP00000386845; ENSG00000144331. [Q569K4-1]
GeneIDi151126.
KEGGihsa:151126.
UCSCiuc002unj.4. human. [Q569K4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057999 mRNA. Translation: BAB71629.1.
AK096822 mRNA. Translation: BAC04870.1.
AK131432 mRNA. Translation: BAD18578.1.
BC038422 mRNA. Translation: AAH38422.1.
BC048123 mRNA. Translation: AAH48123.1.
BC092423 mRNA. Translation: AAH92423.1.
CCDSiCCDS33339.1. [Q569K4-1]
CCDS46463.1. [Q569K4-2]
CCDS46464.1. [Q569K4-3]
RefSeqiNP_001106868.1. NM_001113397.1. [Q569K4-2]
NP_001106869.1. NM_001113398.1. [Q569K4-3]
NP_001269654.1. NM_001282725.1. [Q569K4-3]
NP_689733.3. NM_152520.4. [Q569K4-1]
UniGeneiHs.655005.

3D structure databases

ProteinModelPortaliQ569K4.
SMRiQ569K4. Positions 345-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127344. 2 interactions.
STRINGi9606.ENSP00000386845.

PTM databases

iPTMnetiQ569K4.
PhosphoSiteiQ569K4.

Polymorphism and mutation databases

BioMutaiZNF385B.
DMDMi74741028.

Proteomic databases

PaxDbiQ569K4.
PRIDEiQ569K4.

Protocols and materials databases

DNASUi151126.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336917; ENSP00000338225; ENSG00000144331. [Q569K4-3]
ENST00000409343; ENSP00000386379; ENSG00000144331. [Q569K4-2]
ENST00000409692; ENSP00000386507; ENSG00000144331. [Q569K4-3]
ENST00000410066; ENSP00000386845; ENSG00000144331. [Q569K4-1]
GeneIDi151126.
KEGGihsa:151126.
UCSCiuc002unj.4. human. [Q569K4-1]

Organism-specific databases

CTDi151126.
GeneCardsiZNF385B.
HGNCiHGNC:26332. ZNF385B.
MIMi612344. gene.
neXtProtiNX_Q569K4.
PharmGKBiPA162410114.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHAD. Eukaryota.
ENOG410Y1ZH. LUCA.
GeneTreeiENSGT00390000002371.
HOGENOMiHOG000231865.
HOVERGENiHBG054524.
InParanoidiQ569K4.
OMAiTGNNSDK.
OrthoDBiEOG7XPZ67.
PhylomeDBiQ569K4.
TreeFamiTF326622.

Miscellaneous databases

ChiTaRSiZNF385B. human.
GenomeRNAii151126.
PROiQ569K4.
SOURCEiSearch...

Gene expression databases

BgeeiQ569K4.
CleanExiHS_ZNF385B.
ExpressionAtlasiQ569K4. baseline and differential.
GenevisibleiQ569K4. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 5).
    Tissue: Gastric mucosa, Prostate and Synovial cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: Brain and Testis.
  3. "ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis."
    Iijima K., Yamada H., Miharu M., Imadome K., Miyagawa Y., Akimoto S., Kobayashi K., Okita H., Nakazawa A., Fujiwara S., Fujimoto J., Kiyokawa N.
    Eur. J. Immunol. 42:3405-3415(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN APOPTOSIS, SUBCELLULAR LOCATION, INTERACTION WITH TP53, TISSUE SPECIFICITY.
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiZ385B_HUMAN
AccessioniPrimary (citable) accession number: Q569K4
Secondary accession number(s): Q49A04
, Q6ZMZ7, Q8IY01, Q8N8H2, Q96DK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 10, 2005
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.