Q569H4 (PRR16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proline-rich protein 16

Alternative name(s):
Mesenchymal stem cell protein DSC54

Gene names

Name:

PRR16

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q569H4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q569H4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Isoform 3 (identifier: Q569H4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MSAKSKGNPS...LKDVAKELKE → MAQSGLTATSASQVQAILLPQPASVRHYAW

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Proline-rich protein 16		PRO_0000308159
Regions
	Coiled coil	33 – 70	38	Potential
	Compositional bias	102 – 291	190	Pro-rich
Natural variations
	Alternative sequence	1 – 70	70	Missing in isoform 2.		VSP_028880
	Alternative sequence	1 – 53	53	MSAKS…KELKE → MAQSGLTATSASQVQAILLP QPASVRHYAW in isoform 3.		VSP_028881
	Natural variant	110	1	P → T. Ref.3 Corresponds to variant rs17853861 [ dbSNP | Ensembl ].		VAR_061694

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 42FF6EFF0AE2D2BF	FASTA	304	32,812
	10 20 30 40 50 60 MSAKSKGNPS SSCPAEGPPA ASKTKVKEQI KIIVEDLELV LGDLKDVAKE LKEVVDQIDT 70 80 90 100 110 120 LTSDLQLEDE MTDSSKTDTL NSSSSGTTAS SLEKIKVQAN APLIKPPAHP SAILTVLRKP 130 140 150 160 170 180 NPPPPPPRLT PVKCEDPKRV VPTANPVKTN GTLLRNGGLP GGPNKIPNGD ICCIPNSNLD 190 200 210 220 230 240 KAPVQLLMHR PEKDRCPQAG PRERVRFNEK VQYHGYCPDC DTRYNIKNRE VHLHSEPVHP 250 260 270 280 290 300 PGKIPHQGPP LPPTPHLPPF PLENGGMGIS HSNSFPPIRP ATVPPPTAPK PQKTILRKST TTTV
	Isoform 2 [UniParc]. Checksum: 753AD3C385F6E865	FASTA	234	25,306
	10 20 30 40 50 60 MTDSSKTDTL NSSSSGTTAS SLEKIKVQAN APLIKPPAHP SAILTVLRKP NPPPPPPRLT 70 80 90 100 110 120 PVKCEDPKRV VPTANPVKTN GTLLRNGGLP GGPNKIPNGD ICCIPNSNLD KAPVQLLMHR 130 140 150 160 170 180 PEKDRCPQAG PRERVRFNEK VQYHGYCPDC DTRYNIKNRE VHLHSEPVHP PGKIPHQGPP 190 200 210 220 230 LPPTPHLPPF PLENGGMGIS HSNSFPPIRP ATVPPPTAPK PQKTILRKST TTTV
	Isoform 3 [UniParc]. Checksum: 3BA8E7A63DCB8F24	FASTA	281	30,387
	10 20 30 40 50 60 MAQSGLTATS ASQVQAILLP QPASVRHYAW VVDQIDTLTS DLQLEDEMTD SSKTDTLNSS 70 80 90 100 110 120 SSGTTASSLE KIKVQANAPL IKPPAHPSAI LTVLRKPNPP PPPPRLTPVK CEDPKRVVPT 130 140 150 160 170 180 ANPVKTNGTL LRNGGLPGGP NKIPNGDICC IPNSNLDKAP VQLLMHRPEK DRCPQAGPRE 190 200 210 220 230 240 RVRFNEKVQY HGYCPDCDTR YNIKNREVHL HSEPVHPPGK IPHQGPPLPP TPHLPPFPLE 250 260 270 280 NGGMGISHSN SFPPIRPATV PPPTAPKPQK TILRKSTTTT V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA DSC54 expressed by osteogenic human mesenchymal stem cells." van den Bos C., Mbalaviele G., Thiede M. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-110. Tissue: Brain and Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF242769 mRNA. Translation: AAF65446.1. CH471086 Genomic DNA. Translation: EAW48904.1. CH471086 Genomic DNA. Translation: EAW48906.1. BC038838 mRNA. Translation: AAH38838.1. BC092474 mRNA. Translation: AAH92474.1.
IPI	IPI00555909. IPI00747522. IPI00868998.
RefSeq	NP_057728.1. NM_016644.1.
UniGene	Hs.157461.
3D structure databases
ProteinModelPortal	Q569H4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q569H4. 1 interaction.
Polymorphism databases
DMDM	74735958.
Proteomic databases
PaxDb	Q569H4.
PRIDE	Q569H4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379551; ENSP00000368869; ENSG00000184838. ENST00000407149; ENSP00000385118; ENSG00000184838. ENST00000446965; ENSP00000405491; ENSG00000184838. ENST00000505123; ENSP00000423446; ENSG00000184838.
GeneID	51334.
KEGG	hsa:51334.
UCSC	uc003ksp.3. human. uc003ksq.3. human.
Organism-specific databases
CTD	51334.
GeneCards	GC05P119828.
HGNC	HGNC:29654. PRR16.
HPA	HPA049254.
neXtProt	NX_Q569H4.
PharmGKB	PA162400155.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44576.
HOGENOM	HOG000015766.
HOVERGEN	HBG100197.
InParanoid	Q569H4.
OMA	VQPLMHR.
OrthoDB	EOG4Z36FV.
Gene expression databases
ArrayExpress	Q569H4.
Bgee	Q569H4.
CleanEx	HS_PRR16.
Genevestigator	Q569H4.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	51334.
NextBio	54755.

Entry information

Entry name

PRR16_HUMAN

Accession

Primary (citable) accession number: Q569H4
Secondary accession number(s): D3DSZ0, Q8IXY1, Q9NYI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	May 10, 2005
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.