Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cellular tumor antigen p53

Gene

Trp63

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processApoptosisUniRule annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53UniRule annotation
Gene namesi
Name:Trp63Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1330810 Trp63

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000022510

Interactioni

Subunit structurei

Binds DNA as a homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 264P53InterPro annotationAdd BLAST195
Domaini297 – 336P53_tetramerInterPro annotationAdd BLAST40

Sequence similaritiesi

Belongs to the p53 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IGE4 Eukaryota
ENOG410XV9W LUCA
GeneTreeiENSGT00390000015092
HOGENOMiHOG000039956
HOVERGENiHBG005201

Family and domain databases

CDDicd08367 P53, 1 hit
Gene3Di2.60.40.720, 1 hit
4.10.170.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR002117 p53_tumour_suppressor
IPR032645 Tp63
PANTHERiPTHR11447 PTHR11447, 1 hit
PTHR11447:SF8 PTHR11447:SF8, 1 hit
PfamiView protein in Pfam
PF00870 P53, 1 hit
PF07710 P53_tetramer, 1 hit
PRINTSiPR00386 P53SUPPRESSR
SUPFAMiSSF47719 SSF47719, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS00348 P53, 1 hit

Sequencei

Sequence statusi: Complete.

Q569E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT
60 70 80 90 100
APSPYAQPSS TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY
110 120 130 140 150
STELKKLYCQ IAKTCPIQIK VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC
160 170 180 190 200
PNHELSREFN EGQIAPPSHL IRVEGNSHAQ YVEDPITGRQ SVLVPYEPPQ
210 220 230 240 250
VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV LGRRCFEARI
260 270 280 290 300
CACPGRDRKA DEDSIRKQQV SDSAKNGDGT KRPFRQNTHG IQMTSIKKRR
310 320 330 340 350
SPDDELLYLP VRGRETYEML LKIKESLELM QYLPQHTIET YRQQQQQQHQ
360 370 380 390
HLLQKHLLSA CFRNELVEPR GEAPTQSDVF FRHSNPPNHS VYP
Length:393
Mass (Da):44,439
Last modified:May 10, 2005 - v1
Checksum:iD72C8DEF2384BD1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC109213 Genomic DNA No translation available.
AC113020 Genomic DNA No translation available.
BC092537 mRNA Translation: AAH92537.1
RefSeqiNP_001120733.1, NM_001127261.1
NP_001120735.1, NM_001127263.1
NP_001120737.1, NM_001127265.1
UniGeneiMm.20894

Genome annotation databases

EnsembliENSMUST00000115305; ENSMUSP00000110960; ENSMUSG00000022510
GeneIDi22061
UCSCiuc007yur.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ569E5_MOUSE
AccessioniPrimary (citable) accession number: Q569E5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health