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Protein

Histone deacetylase 10

Gene

Hdac10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei135By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 10 (EC:3.5.1.98)
Short name:
HD10
Gene namesi
Name:Hdac10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305874 Hdac10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147141 – 588Histone deacetylase 10Add BLAST588

Proteomic databases

PaxDbiQ569C4
PRIDEiQ569C4

Expressioni

Gene expression databases

BgeeiENSRNOG00000031915
GenevisibleiQ569C4 RN

Interactioni

Subunit structurei

Interacts with HDAC2, HDAC3 and NCOR2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052717

Structurei

3D structure databases

ProteinModelPortaliQ569C4
SMRiQ569C4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 302Histone deacetylaseAdd BLAST302

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00530000062809
HOGENOMiHOG000225183
HOVERGENiHBG051892
InParanoidiQ569C4
KOiK18671
OrthoDBiEOG091G0210

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 2 hits
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 2 hits

Sequencei

Sequence statusi: Complete.

Q569C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCQCL
60 70 80 90 100
SVCEASEEEL GLVHSPEYIA LVQKTQTLDK EELHTLSKQY DAVYFHPDTF
110 120 130 140 150
HCARLAAGAA LRLVDAVLTG AVHNGVALVR PPGHHSQRAA ANGFCVFNNV
160 170 180 190 200
AIAARHAKQK YGLQRILIVD WDVHHGQGIQ YIFEDDPSVL YFSWHRYEHG
210 220 230 240 250
NFWPFLPESD ADTVGRGRGQ GFTVNLPWNQ VGMGNADYLA AFLHVLLPLA
260 270 280 290 300
FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV
310 320 330 340 350
LECPGVYPEC SDSPDPSLDK PPTNSTCTVA EDSLSPCLDR PCHRPTPPIC
360 370 380 390 400
IAVALAVSGA ALDLPPGVLH QEGSALREET EAWARLHKSQ FQDDDLAALG
410 420 430 440 450
KSLCLLDGIL DGQIRSAIAT TTALATAATL GVLIQRCVAH RGQRRILWLS
460 470 480 490 500
IRGKEADIWS MFHFSTPLPQ TTGGFLSFIL GLVLPLAYGF QPDMVLMALG
510 520 530 540 550
PAHGLQNAQA ALLAAMLRSP VGGRILALVE EESILQLART LAQVLHGETP
560 570 580
PSLGPFSMAS PEEIQALMFL KAQLEPRWKL LQVAAPPP
Length:588
Mass (Da):63,957
Last modified:May 10, 2005 - v1
Checksum:i3708DDEAE2D5EA59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092573 mRNA Translation: AAH92573.1
RefSeqiNP_001030172.1, NM_001035000.1
UniGeneiRn.107028

Genome annotation databases

EnsembliENSRNOT00000055865; ENSRNOP00000052717; ENSRNOG00000031915
GeneIDi362981
KEGGirno:362981

Similar proteinsi

Entry informationi

Entry nameiHDA10_RAT
AccessioniPrimary (citable) accession number: Q569C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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