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Q569C4

- HDA10_RAT

UniProt

Q569C4 - HDA10_RAT

Protein

Histone deacetylase 10

Gene

Hdac10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei135 – 1351By similarity

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    2. oligodendrocyte development Source: RGD
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_198659. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_198750. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_198752. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 10 (EC:3.5.1.98)
    Short name:
    HD10
    Gene namesi
    Name:Hdac10
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi1305874. Hdac10.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Excluded from the nucleoli.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. histone deacetylase complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 588588Histone deacetylase 10PRO_0000114714Add
    BLAST

    Proteomic databases

    PRIDEiQ569C4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ569C4.

    Interactioni

    Subunit structurei

    Interacts with HDAC2, HDAC3 and NCOR2.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000048906.

    Structurei

    3D structure databases

    ProteinModelPortaliQ569C4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 302302Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    GeneTreeiENSGT00530000062809.
    HOGENOMiHOG000225183.
    HOVERGENiHBG051892.
    KOiK11407.
    OMAiPICIAVA.
    OrthoDBiEOG7992PT.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q569C4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCQCL    50
    SVCEASEEEL GLVHSPEYIA LVQKTQTLDK EELHTLSKQY DAVYFHPDTF 100
    HCARLAAGAA LRLVDAVLTG AVHNGVALVR PPGHHSQRAA ANGFCVFNNV 150
    AIAARHAKQK YGLQRILIVD WDVHHGQGIQ YIFEDDPSVL YFSWHRYEHG 200
    NFWPFLPESD ADTVGRGRGQ GFTVNLPWNQ VGMGNADYLA AFLHVLLPLA 250
    FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV 300
    LECPGVYPEC SDSPDPSLDK PPTNSTCTVA EDSLSPCLDR PCHRPTPPIC 350
    IAVALAVSGA ALDLPPGVLH QEGSALREET EAWARLHKSQ FQDDDLAALG 400
    KSLCLLDGIL DGQIRSAIAT TTALATAATL GVLIQRCVAH RGQRRILWLS 450
    IRGKEADIWS MFHFSTPLPQ TTGGFLSFIL GLVLPLAYGF QPDMVLMALG 500
    PAHGLQNAQA ALLAAMLRSP VGGRILALVE EESILQLART LAQVLHGETP 550
    PSLGPFSMAS PEEIQALMFL KAQLEPRWKL LQVAAPPP 588
    Length:588
    Mass (Da):63,957
    Last modified:May 10, 2005 - v1
    Checksum:i3708DDEAE2D5EA59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC092573 mRNA. Translation: AAH92573.1.
    RefSeqiNP_001030172.1. NM_001035000.1.
    UniGeneiRn.107028.

    Genome annotation databases

    EnsembliENSRNOT00000055865; ENSRNOP00000052717; ENSRNOG00000031915.
    GeneIDi362981.
    KEGGirno:362981.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC092573 mRNA. Translation: AAH92573.1 .
    RefSeqi NP_001030172.1. NM_001035000.1.
    UniGenei Rn.107028.

    3D structure databases

    ProteinModelPortali Q569C4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000048906.

    Proteomic databases

    PRIDEi Q569C4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000055865 ; ENSRNOP00000052717 ; ENSRNOG00000031915 .
    GeneIDi 362981.
    KEGGi rno:362981.

    Organism-specific databases

    CTDi 83933.
    RGDi 1305874. Hdac10.

    Phylogenomic databases

    eggNOGi COG0123.
    GeneTreei ENSGT00530000062809.
    HOGENOMi HOG000225183.
    HOVERGENi HBG051892.
    KOi K11407.
    OMAi PICIAVA.
    OrthoDBi EOG7992PT.

    Enzyme and pathway databases

    Reactomei REACT_198659. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_198750. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_198752. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Miscellaneous databases

    NextBioi 682020.
    PROi Q569C4.

    Gene expression databases

    Genevestigatori Q569C4.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiHDA10_RAT
    AccessioniPrimary (citable) accession number: Q569C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3