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Protein

Histone deacetylase 10

Gene

Hdac10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_274139. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_361585. HDACs deacetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 10 (EC:3.5.1.98)
Short name:
HD10
Gene namesi
Name:Hdac10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305874. Hdac10.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Excluded from the nucleoli.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Histone deacetylase 10PRO_0000114714Add
BLAST

Proteomic databases

PRIDEiQ569C4.

Expressioni

Gene expression databases

GenevisibleiQ569C4. RN.

Interactioni

Subunit structurei

Interacts with HDAC2, HDAC3 and NCOR2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052717.

Structurei

3D structure databases

ProteinModelPortaliQ569C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 302302Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000225183.
HOVERGENiHBG051892.
InParanoidiQ569C4.
KOiK18671.
OrthoDBiEOG7992PT.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q569C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCQCL
60 70 80 90 100
SVCEASEEEL GLVHSPEYIA LVQKTQTLDK EELHTLSKQY DAVYFHPDTF
110 120 130 140 150
HCARLAAGAA LRLVDAVLTG AVHNGVALVR PPGHHSQRAA ANGFCVFNNV
160 170 180 190 200
AIAARHAKQK YGLQRILIVD WDVHHGQGIQ YIFEDDPSVL YFSWHRYEHG
210 220 230 240 250
NFWPFLPESD ADTVGRGRGQ GFTVNLPWNQ VGMGNADYLA AFLHVLLPLA
260 270 280 290 300
FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV
310 320 330 340 350
LECPGVYPEC SDSPDPSLDK PPTNSTCTVA EDSLSPCLDR PCHRPTPPIC
360 370 380 390 400
IAVALAVSGA ALDLPPGVLH QEGSALREET EAWARLHKSQ FQDDDLAALG
410 420 430 440 450
KSLCLLDGIL DGQIRSAIAT TTALATAATL GVLIQRCVAH RGQRRILWLS
460 470 480 490 500
IRGKEADIWS MFHFSTPLPQ TTGGFLSFIL GLVLPLAYGF QPDMVLMALG
510 520 530 540 550
PAHGLQNAQA ALLAAMLRSP VGGRILALVE EESILQLART LAQVLHGETP
560 570 580
PSLGPFSMAS PEEIQALMFL KAQLEPRWKL LQVAAPPP
Length:588
Mass (Da):63,957
Last modified:May 10, 2005 - v1
Checksum:i3708DDEAE2D5EA59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092573 mRNA. Translation: AAH92573.1.
RefSeqiNP_001030172.1. NM_001035000.1.
UniGeneiRn.107028.

Genome annotation databases

EnsembliENSRNOT00000055865; ENSRNOP00000052717; ENSRNOG00000031915.
GeneIDi362981.
KEGGirno:362981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092573 mRNA. Translation: AAH92573.1.
RefSeqiNP_001030172.1. NM_001035000.1.
UniGeneiRn.107028.

3D structure databases

ProteinModelPortaliQ569C4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052717.

Proteomic databases

PRIDEiQ569C4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055865; ENSRNOP00000052717; ENSRNOG00000031915.
GeneIDi362981.
KEGGirno:362981.

Organism-specific databases

CTDi83933.
RGDi1305874. Hdac10.

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000225183.
HOVERGENiHBG051892.
InParanoidiQ569C4.
KOiK18671.
OrthoDBiEOG7992PT.

Enzyme and pathway databases

ReactomeiREACT_274139. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_361585. HDACs deacetylate histones.

Miscellaneous databases

NextBioi682020.
PROiQ569C4.

Gene expression databases

GenevisibleiQ569C4. RN.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiHDA10_RAT
AccessioniPrimary (citable) accession number: Q569C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 10, 2005
Last modified: July 22, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.