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Q569C4

- HDA10_RAT

UniProt

Q569C4 - HDA10_RAT

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Protein

Histone deacetylase 10

Gene

Hdac10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. oligodendrocyte development Source: RGD
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_198659. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_198750. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_198752. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 10 (EC:3.5.1.98)
Short name:
HD10
Gene namesi
Name:Hdac10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi1305874. Hdac10.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Excluded from the nucleoli.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. histone deacetylase complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Histone deacetylase 10PRO_0000114714Add
BLAST

Proteomic databases

PRIDEiQ569C4.

Expressioni

Gene expression databases

GenevestigatoriQ569C4.

Interactioni

Subunit structurei

Interacts with HDAC2, HDAC3 and NCOR2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048906.

Structurei

3D structure databases

ProteinModelPortaliQ569C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 302302Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000225183.
HOVERGENiHBG051892.
InParanoidiQ569C4.
KOiK11407.
OMAiPICIAVA.
OrthoDBiEOG7992PT.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q569C4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCQCL
60 70 80 90 100
SVCEASEEEL GLVHSPEYIA LVQKTQTLDK EELHTLSKQY DAVYFHPDTF
110 120 130 140 150
HCARLAAGAA LRLVDAVLTG AVHNGVALVR PPGHHSQRAA ANGFCVFNNV
160 170 180 190 200
AIAARHAKQK YGLQRILIVD WDVHHGQGIQ YIFEDDPSVL YFSWHRYEHG
210 220 230 240 250
NFWPFLPESD ADTVGRGRGQ GFTVNLPWNQ VGMGNADYLA AFLHVLLPLA
260 270 280 290 300
FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV
310 320 330 340 350
LECPGVYPEC SDSPDPSLDK PPTNSTCTVA EDSLSPCLDR PCHRPTPPIC
360 370 380 390 400
IAVALAVSGA ALDLPPGVLH QEGSALREET EAWARLHKSQ FQDDDLAALG
410 420 430 440 450
KSLCLLDGIL DGQIRSAIAT TTALATAATL GVLIQRCVAH RGQRRILWLS
460 470 480 490 500
IRGKEADIWS MFHFSTPLPQ TTGGFLSFIL GLVLPLAYGF QPDMVLMALG
510 520 530 540 550
PAHGLQNAQA ALLAAMLRSP VGGRILALVE EESILQLART LAQVLHGETP
560 570 580
PSLGPFSMAS PEEIQALMFL KAQLEPRWKL LQVAAPPP
Length:588
Mass (Da):63,957
Last modified:May 10, 2005 - v1
Checksum:i3708DDEAE2D5EA59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC092573 mRNA. Translation: AAH92573.1.
RefSeqiNP_001030172.1. NM_001035000.1.
UniGeneiRn.107028.

Genome annotation databases

EnsembliENSRNOT00000055865; ENSRNOP00000052717; ENSRNOG00000031915.
GeneIDi362981.
KEGGirno:362981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC092573 mRNA. Translation: AAH92573.1 .
RefSeqi NP_001030172.1. NM_001035000.1.
UniGenei Rn.107028.

3D structure databases

ProteinModelPortali Q569C4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000048906.

Proteomic databases

PRIDEi Q569C4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000055865 ; ENSRNOP00000052717 ; ENSRNOG00000031915 .
GeneIDi 362981.
KEGGi rno:362981.

Organism-specific databases

CTDi 83933.
RGDi 1305874. Hdac10.

Phylogenomic databases

eggNOGi COG0123.
GeneTreei ENSGT00530000062809.
HOGENOMi HOG000225183.
HOVERGENi HBG051892.
InParanoidi Q569C4.
KOi K11407.
OMAi PICIAVA.
OrthoDBi EOG7992PT.

Enzyme and pathway databases

Reactomei REACT_198659. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_198750. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_198752. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Miscellaneous databases

NextBioi 682020.
PROi Q569C4.

Gene expression databases

Genevestigatori Q569C4.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiHDA10_RAT
AccessioniPrimary (citable) accession number: Q569C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3