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Q569C4 (HDA10_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone deacetylase 10

Short name=HD10
EC=3.5.1.98
Gene names
Name:Hdac10
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subunit structure

Interacts with HDAC2, HDAC3 and NCOR2 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Excluded from the nucleoli By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588Histone deacetylase 10
PRO_0000114714

Regions

Region1 – 302302Histone deacetylase

Sites

Active site1351 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q569C4 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 3708DDEAE2D5EA59

FASTA58863,957
        10         20         30         40         50         60 
MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCQCL SVCEASEEEL 

        70         80         90        100        110        120 
GLVHSPEYIA LVQKTQTLDK EELHTLSKQY DAVYFHPDTF HCARLAAGAA LRLVDAVLTG 

       130        140        150        160        170        180 
AVHNGVALVR PPGHHSQRAA ANGFCVFNNV AIAARHAKQK YGLQRILIVD WDVHHGQGIQ 

       190        200        210        220        230        240 
YIFEDDPSVL YFSWHRYEHG NFWPFLPESD ADTVGRGRGQ GFTVNLPWNQ VGMGNADYLA 

       250        260        270        280        290        300 
AFLHVLLPLA FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV 

       310        320        330        340        350        360 
LECPGVYPEC SDSPDPSLDK PPTNSTCTVA EDSLSPCLDR PCHRPTPPIC IAVALAVSGA 

       370        380        390        400        410        420 
ALDLPPGVLH QEGSALREET EAWARLHKSQ FQDDDLAALG KSLCLLDGIL DGQIRSAIAT 

       430        440        450        460        470        480 
TTALATAATL GVLIQRCVAH RGQRRILWLS IRGKEADIWS MFHFSTPLPQ TTGGFLSFIL 

       490        500        510        520        530        540 
GLVLPLAYGF QPDMVLMALG PAHGLQNAQA ALLAAMLRSP VGGRILALVE EESILQLART 

       550        560        570        580 
LAQVLHGETP PSLGPFSMAS PEEIQALMFL KAQLEPRWKL LQVAAPPP 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC092573 mRNA. Translation: AAH92573.1.
RefSeqNP_001030172.1. NM_001035000.1.
UniGeneRn.107028.

3D structure databases

ProteinModelPortalQ569C4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000048906.

Proteomic databases

PRIDEQ569C4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000055865; ENSRNOP00000052717; ENSRNOG00000031915.
GeneID362981.
KEGGrno:362981.

Organism-specific databases

CTD83933.
RGD1305874. Hdac10.

Phylogenomic databases

eggNOGCOG0123.
GeneTreeENSGT00530000062809.
HOGENOMHOG000225183.
HOVERGENHBG051892.
KOK11407.
OMAPICIAVA.
OrthoDBEOG7992PT.

Gene expression databases

GenevestigatorQ569C4.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSPR01270. HDASUPER.
ProtoNetSearch...

Other

NextBio682020.
PROQ569C4.

Entry information

Entry nameHDA10_RAT
AccessionPrimary (citable) accession number: Q569C4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families