Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat-containing protein 14

Gene

Lrrc14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 14By similarity
Gene namesi
Name:Lrrc14Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1560202. Lrrc14.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003436821 – 493Leucine-rich repeat-containing protein 14Add BLAST493

Proteomic databases

PaxDbiQ569B5.
PRIDEiQ569B5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016128.
ExpressionAtlasiQ569B5. baseline.
GenevisibleiQ569B5. RN.

Interactioni

Subunit structurei

Interacts with IKBKB; disrupts IKBKB-IKBKG interaction preventing I-kappa-B-kinase (IKK) core complex formation and leading to a decrease of IKBKB phosphorylation and NF-kappaB activation. Interacts with CHUK.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021673.

Structurei

3D structure databases

ProteinModelPortaliQ569B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati111 – 146LRR 1; degenerateBy similarityAdd BLAST36
Repeati194 – 218LRR 2; degenerateBy similarityAdd BLAST25
Repeati219 – 246LRR 3; degenerateBy similarityAdd BLAST28
Repeati247 – 282LRR 4; degenerateBy similarityAdd BLAST36
Repeati283 – 307LRR 5By similarityAdd BLAST25
Repeati308 – 339LRR 6By similarityAdd BLAST32
Repeati340 – 360LRR 7By similarityAdd BLAST21
Repeati364 – 391LRR 8By similarityAdd BLAST28
Repeati392 – 416LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family. LRRC14 subfamily.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IIBA. Eukaryota.
ENOG4111FCX. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113363.
HOVERGENiHBG052342.
InParanoidiQ569B5.
PhylomeDBiQ569B5.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR001611. Leu-rich_rpt.
IPR032675. LRR_dom_sf.
IPR026292. LRRC14.
PANTHERiPTHR14224:SF9. PTHR14224:SF9. 1 hit.
PfamiView protein in Pfam
PF13516. LRR_6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q569B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTAVLREL
60 70 80 90 100
VHTWPFPLLS FQQLLQECAH CSRALLQERL STESMQAVIL GLTARIHARE
110 120 130 140 150
AEAGTQPVCR KHTLRVLDMT GLLDDGVEQD PGTMSMWDCT AAVARTCIAQ
160 170 180 190 200
QQVGTAKPGL SPVPVEIRVD LRVNRASYTF LREALQSSVD SLLRLCCRDL
210 220 230 240 250
RAEDLPMRNT VALLQLLDAG CLRRIDLRFN NLGLRGLSVI IPHVARFQHL
260 270 280 290 300
ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFICLRELS IGSSLLSGRL
310 320 330 340 350
DQLLSTLQRP LESLELAFCA LLPEDLRFLA QSSHAAHLKK LDLSGNDLSG
360 370 380 390 400
NQLTPFQGLL QAVAATLLHL ELTECQIADA QLLATLPTLT RCASLRYLGL
410 420 430 440 450
YGNPLSMAGL KELLRDSVIQ AELRTVVHPF PVDCYEGLPW PPPASVLLEA
460 470 480 490
SINEEKFARV EAELHQLLLA SGRAHVLWTT DIYGRLAADY FNL
Length:493
Mass (Da):54,915
Last modified:May 10, 2005 - v1
Checksum:i6810AE5070F45B08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473950 Genomic DNA. Translation: EDM15941.1.
CH473950 Genomic DNA. Translation: EDM15942.1.
BC092583 mRNA. Translation: AAH92583.1.
RefSeqiNP_001019525.1. NM_001024354.1.
XP_006241924.1. XM_006241862.3.
XP_006241927.1. XM_006241865.2.
XP_017450542.1. XM_017595053.1.
UniGeneiRn.138067.

Genome annotation databases

EnsembliENSRNOT00000021673; ENSRNOP00000021673; ENSRNOG00000016128.
GeneIDi500900.
KEGGirno:500900.
UCSCiRGD:1560202. rat.

Similar proteinsi

Entry informationi

Entry nameiLRC14_RAT
AccessioniPrimary (citable) accession number: Q569B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 10, 2005
Last modified: November 22, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families