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Protein

Hemin import ATP-binding protein HmuV

Gene

hmuV

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (Probable).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.1.14.5 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Hemin import ATP-binding protein HmuVUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:hmuVUniRule annotation
Ordered Locus Names:YPO0279, y0539, YP_0434
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923921 – 266Hemin import ATP-binding protein HmuVAdd BLAST266

Proteomic databases

PaxDbiQ56993

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HmuV), two transmembrane proteins (HmuU) and a solute-binding protein (HmuT).UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
hmuUQ569923EBI-2866017,EBI-16023192

Protein-protein interaction databases

DIPiDIP-60001N
IntActiQ56993, 3 interactors
STRINGi187410.y0539

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 21Combined sources11
Beta strandi24 – 35Combined sources12
Beta strandi39 – 43Combined sources5
Helixi50 – 57Combined sources8
Beta strandi59 – 61Combined sources3
Beta strandi67 – 70Combined sources4
Turni75 – 77Combined sources3
Helixi80 – 86Combined sources7
Beta strandi87 – 90Combined sources4
Helixi102 – 107Combined sources6
Helixi108 – 110Combined sources3
Helixi118 – 128Combined sources11
Turni133 – 136Combined sources4
Helixi139 – 141Combined sources3
Helixi144 – 158Combined sources15
Beta strandi167 – 171Combined sources5
Helixi180 – 196Combined sources17
Beta strandi197 – 204Combined sources8
Helixi208 – 214Combined sources7
Beta strandi216 – 222Combined sources7
Beta strandi225 – 230Combined sources6
Helixi232 – 235Combined sources4
Helixi238 – 244Combined sources7
Beta strandi249 – 253Combined sources5
Beta strandi255 – 264Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4G1UX-ray3.01C/D1-266[»]
ProteinModelPortaliQ56993
SMRiQ56993
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 248ABC transporterUniRule annotationAdd BLAST237

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family. [View classification]UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IPX Bacteria
COG4559 LUCA
KOiK02013
OMAiHQHNTLR

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR015863 ABC_transpr_HmuV
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51261 HMUV, 1 hit

Sequencei

Sequence statusi: Complete.

Q56993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDMAVTPVA LLEASHLHYH VQQQALINDV SLHIASGEMV AIIGPNGAGK
60 70 80 90 100
STLLRLLTGY LSPSHGECHL LGQNLNSWQP KALARTRAVM RQYSELAFPF
110 120 130 140 150
SVSEVIQMGR APYGGSQDRQ ALQQVMAQTD CLALAQRDYR VLSGGEQQRV
160 170 180 190 200
QLARVLAQLW QPQPTPRWLF LDEPTSALDL YHQQHTLRLL RQLTRQEPLA
210 220 230 240 250
VCCVLHDLNL AALYADRIML LAQGKLVACG TPEEVLNAET LTQWYQADLG
260
VSRHPESALP QIYLRQ
Length:266
Mass (Da):29,658
Last modified:November 1, 1997 - v1
Checksum:i4A7DEB955583CB27
GO

Sequence cautioni

The sequence AAM84127 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60647 Genomic DNA Translation: AAC64870.1
AL590842 Genomic DNA Translation: CAL18965.1
AE009952 Genomic DNA Translation: AAM84127.1 Different initiation.
AE017042 Genomic DNA Translation: AAS60705.1
PIRiAC0035
T12073
RefSeqiWP_002209058.1, NZ_PDBR01000018.1
YP_002345361.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM84127; AAM84127; y0539
AAS60705; AAS60705; YP_0434
GeneIDi1173125
KEGGiype:YPO0279
ypk:y0539
ypm:YP_0434
PATRICifig|1028802.3.peg.940

Similar proteinsi

Entry informationi

Entry nameiHMUV_YERPE
AccessioniPrimary (citable) accession number: Q56993
Secondary accession number(s): Q0WK27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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