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Protein

Hemin import ATP-binding protein HmuV

Gene

hmuV

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (Probable).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 518ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-278-MONOMER.

Protein family/group databases

TCDBi3.A.1.14.5. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemin import ATP-binding protein HmuVUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:hmuVUniRule annotation
Ordered Locus Names:YPO0279, y0539, YP_0434
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Hemin import ATP-binding protein HmuVPRO_0000092392Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HmuV), two transmembrane proteins (HmuU) and a solute-binding protein (HmuT).UniRule annotation

Protein-protein interaction databases

DIPiDIP-60001N.
IntActiQ56993. 1 interaction.
STRINGi187410.y0539.

Structurei

Secondary structure

1
266
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 2111Combined sources
Beta strandi24 – 3512Combined sources
Beta strandi39 – 435Combined sources
Helixi50 – 578Combined sources
Beta strandi59 – 613Combined sources
Beta strandi67 – 704Combined sources
Turni75 – 773Combined sources
Helixi80 – 867Combined sources
Beta strandi87 – 904Combined sources
Helixi102 – 1076Combined sources
Helixi108 – 1103Combined sources
Helixi118 – 12811Combined sources
Turni133 – 1364Combined sources
Helixi139 – 1413Combined sources
Helixi144 – 15815Combined sources
Beta strandi167 – 1715Combined sources
Helixi180 – 19617Combined sources
Beta strandi197 – 2048Combined sources
Helixi208 – 2147Combined sources
Beta strandi216 – 2227Combined sources
Beta strandi225 – 2306Combined sources
Helixi232 – 2354Combined sources
Helixi238 – 2447Combined sources
Beta strandi249 – 2535Combined sources
Beta strandi255 – 26410Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4G1UX-ray3.01C/D1-266[»]
ProteinModelPortaliQ56993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 248237ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IPX. Bacteria.
COG4559. LUCA.
KOiK02013.
OMAiRIGHKPV.
OrthoDBiEOG6VXF80.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015863. ABC_transpr_HmuV.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51261. HMUV. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDMAVTPVA LLEASHLHYH VQQQALINDV SLHIASGEMV AIIGPNGAGK
60 70 80 90 100
STLLRLLTGY LSPSHGECHL LGQNLNSWQP KALARTRAVM RQYSELAFPF
110 120 130 140 150
SVSEVIQMGR APYGGSQDRQ ALQQVMAQTD CLALAQRDYR VLSGGEQQRV
160 170 180 190 200
QLARVLAQLW QPQPTPRWLF LDEPTSALDL YHQQHTLRLL RQLTRQEPLA
210 220 230 240 250
VCCVLHDLNL AALYADRIML LAQGKLVACG TPEEVLNAET LTQWYQADLG
260
VSRHPESALP QIYLRQ
Length:266
Mass (Da):29,658
Last modified:November 1, 1997 - v1
Checksum:i4A7DEB955583CB27
GO

Sequence cautioni

The sequence AAM84127.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60647 Genomic DNA. Translation: AAC64870.1.
AL590842 Genomic DNA. Translation: CAL18965.1.
AE009952 Genomic DNA. Translation: AAM84127.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS60705.1.
PIRiAC0035.
T12073.
RefSeqiWP_002209058.1. NZ_LQAY01000008.1.
YP_002345361.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84127; AAM84127; y0539.
AAS60705; AAS60705; YP_0434.
GeneIDi1173125.
KEGGiype:YPO0279.
ypj:CH55_3481.
ypk:y0539.
ypl:CH46_633.
ypm:YP_0434.
ypv:BZ15_3290.
ypw:CH59_1582.
PATRICi18589601. VBIYerPes7843_0540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60647 Genomic DNA. Translation: AAC64870.1.
AL590842 Genomic DNA. Translation: CAL18965.1.
AE009952 Genomic DNA. Translation: AAM84127.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS60705.1.
PIRiAC0035.
T12073.
RefSeqiWP_002209058.1. NZ_LQAY01000008.1.
YP_002345361.1. NC_003143.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4G1UX-ray3.01C/D1-266[»]
ProteinModelPortaliQ56993.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60001N.
IntActiQ56993. 1 interaction.
STRINGi187410.y0539.

Protein family/group databases

TCDBi3.A.1.14.5. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84127; AAM84127; y0539.
AAS60705; AAS60705; YP_0434.
GeneIDi1173125.
KEGGiype:YPO0279.
ypj:CH55_3481.
ypk:y0539.
ypl:CH46_633.
ypm:YP_0434.
ypv:BZ15_3290.
ypw:CH59_1582.
PATRICi18589601. VBIYerPes7843_0540.

Phylogenomic databases

eggNOGiENOG4108IPX. Bacteria.
COG4559. LUCA.
KOiK02013.
OMAiRIGHKPV.
OrthoDBiEOG6VXF80.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-278-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015863. ABC_transpr_HmuV.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51261. HMUV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the hemin uptake locus (hmu) from Yersinia pestis and analysis of hmu mutants for hemin and hemoprotein utilization."
    Thompson J.M., Jones H.A., Perry R.D.
    Infect. Immun. 67:3879-3892(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN HEMIN TRANSPORT.
    Strain: KIM6.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  4. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiHMUV_YERPE
AccessioniPrimary (citable) accession number: Q56993
Secondary accession number(s): Q0WK27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.