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Protein

Calcium and integrin-binding family member 2

Gene

Cib2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. May be involved in the mechanotransduction process.By similarity

Miscellaneous

The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi116 – 1271PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi157 – 1682PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium and integrin-binding family member 2
Gene namesi
Name:Cib2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1308718. Cib2.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell projectionstereocilium By similarity
  • Photoreceptor inner segment By similarity
  • Cell projectionciliumphotoreceptor outer segment By similarity
  • Cell membranesarcolemma By similarity

  • Note: Colocalized with ITGA7 at the myotendinous junctions (MTJ) and at the neuromuscular junctions (NMJ). Localizes in the cuticular plate along and at the tip of the stereocilia of vestibular sensory hair cells.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892891 – 187Calcium and integrin-binding family member 2Add BLAST187

Proteomic databases

PaxDbiQ568Z7.
PRIDEiQ568Z7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000059834.
GenevisibleiQ568Z7. RN.

Interactioni

Subunit structurei

Homodimer. Interacts with WHRN and MYO7A. Interacts with ITGA2B (via C-terminus cytoplasmic tail region) and ITGA7 (via C-terminus cytoplasmic tail region); the interactions are stabilized/increased in a calcium and magnesium-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013623.

Structurei

3D structure databases

ProteinModelPortaliQ568Z7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 101EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini103 – 138EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini144 – 179EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0038. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00860000133737.
HOGENOMiHOG000233019.
HOVERGENiHBG107344.
InParanoidiQ568Z7.
OMAiDCKLPLA.
OrthoDBiEOG091G0OJZ.
PhylomeDBiQ568Z7.
TreeFamiTF313865.

Family and domain databases

CDDicd00051. EFh. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 3 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q568Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNKQTIFTE EQLDNYQDCT FFNKKDILKL HARFYELAPN LVPMDYRKSP
60 70 80 90 100
IVHVPMSLII QMPELRENPF KERIVEAFSE DGEGNLTFND FVDMFSVLCE
110 120 130 140 150
SAPRELKANY AFKIYDFNTD NFICKEDLEL TLARLTKSEL DEDEVVLVCD
160 170 180
KVIEEADLDG DGKLGFADFE DMIAKAPDFL STFHIRI
Length:187
Mass (Da):21,672
Last modified:May 10, 2005 - v1
Checksum:iB97050DCBC0A6E0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092630 mRNA. Translation: AAH92630.1.
RefSeqiNP_001015010.1. NM_001015010.1.
UniGeneiRn.46320.

Genome annotation databases

EnsembliENSRNOT00000078571; ENSRNOP00000071683; ENSRNOG00000059834.
GeneIDi300719.
KEGGirno:300719.
UCSCiRGD:1308718. rat.

Similar proteinsi

Entry informationi

Entry nameiCIB2_RAT
AccessioniPrimary (citable) accession number: Q568Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 10, 2005
Last modified: August 30, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome