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Protein

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

Gene

Dph2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).By similarity

Catalytic activityi

L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine.By similarity

Pathwayi: peptidyl-diphthamide biosynthesis

This protein is involved in the pathway peptidyl-diphthamide biosynthesis, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway peptidyl-diphthamide biosynthesis and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-RNO-5358493 Synthesis of diphthamide-EEF2
UniPathwayiUPA00559

Names & Taxonomyi

Protein namesi
Recommended name:
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2Curated (EC:2.5.1.108By similarity)
Alternative name(s):
Diphthamide biosynthesis protein 2
Diphtheria toxin resistance protein 2Curated
S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2Curated
Gene namesi
Name:Dph2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1304634 Dph2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078921 – 4892-(3-amino-3-carboxypropyl)histidine synthase subunit 2Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei435PhosphothreonineBy similarity1
Modified residuei446PhosphoserineBy similarity1
Modified residuei456PhosphoserineBy similarity1
Modified residuei467PhosphothreonineBy similarity1
Modified residuei488PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ568Y2
PRIDEiQ568Y2

Expressioni

Gene expression databases

BgeeiENSRNOG00000019735
GenevisibleiQ568Y2 RN

Interactioni

Subunit structurei

Interacts with DPH1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026739

Structurei

3D structure databases

ProteinModelPortaliQ568Y2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DPH1/DPH2 family. DPH2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2648 Eukaryota
COG1736 LUCA
GeneTreeiENSGT00550000075105
HOGENOMiHOG000182223
HOVERGENiHBG107823
InParanoidiQ568Y2
KOiK17866
OMAiFGNACRS
OrthoDBiEOG091G09K9
PhylomeDBiQ568Y2
TreeFamiTF313832

Family and domain databases

InterProiView protein in InterPro
IPR010014 DHP2_euk
IPR016435 DPH1/DPH2
PANTHERiPTHR10762 PTHR10762, 1 hit
PTHR10762:SF2 PTHR10762:SF2, 1 hit
PfamiView protein in Pfam
PF01866 Diphthamide_syn, 1 hit
SFLDiSFLDS00032 Radical_SAM_3-amino-3-carboxyp, 1 hit
TIGRFAMsiTIGR00322 diphth2_R, 1 hit
TIGR00272 DPH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q568Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTFSSPAE AALQREAGVP GQFTPPEDLD RVYELERVTR FICDLGCQRV
60 70 80 90 100
ALQFPDQLLG DAGAVAARLE EVTGSKMFIL GDTAYGSCCV DVLGAEQAGA
110 120 130 140 150
QALVHFGPAC LSPPASLLPI TFVLGRRPVA LELCAKAFEA QNPDPTALVV
160 170 180 190 200
LLSEPACAHA LEPLATLLRP KYQDLLISSP ALPLPVGSLS SQPESLERFG
210 220 230 240 250
RRFPLNPGRS LEEYGAFYVG ASQASSDPNL DPDLSRLLLG WTPGRPFFSC
260 270 280 290 300
CPDTGQTQDQ GAKAGRLRAR RLYLVERARD ARVVGLLVGT LGVAQHLEAL
310 320 330 340 350
AHLRKLTEAA GKRSYVLALG KPTPAKLANF PEMDVFVLLA CPLGALTLQP
360 370 380 390 400
SGGFFRPILT PCELEAACNP AWPPPGLAPH LTHYAELLPG SPFHVPLPPP
410 420 430 440 450
ESELWDTPDV SLISGELRPP PPWKSSDDTK CSALTPRPQL ELAESSPAAS
460 470 480
FLSSRSWQGL EPRLGQTPVK EAVQGRRGIA IAYEDEGSS
Length:489
Mass (Da):52,325
Last modified:May 10, 2005 - v1
Checksum:i8C8F0F4720E9C14F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092656 mRNA Translation: AAH92656.1
RefSeqiNP_001015007.1, NM_001015007.1
UniGeneiRn.49365

Genome annotation databases

EnsembliENSRNOT00000026739; ENSRNOP00000026739; ENSRNOG00000019735
GeneIDi298452
KEGGirno:298452
UCSCiRGD:1304634 rat

Similar proteinsi

Entry informationi

Entry nameiDPH2_RAT
AccessioniPrimary (citable) accession number: Q568Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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