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Protein

Diphthamide biosynthesis protein 2

Gene

Dph2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).By similarity

Pathwayi: peptidyl-diphthamide biosynthesis

This protein is involved in the pathway peptidyl-diphthamide biosynthesis, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway peptidyl-diphthamide biosynthesis and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5358493. Synthesis of diphthamide-EEF2.
UniPathwayiUPA00559.

Names & Taxonomyi

Protein namesi
Recommended name:
Diphthamide biosynthesis protein 2
Alternative name(s):
DPH2 homolog
Gene namesi
Name:Dph2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1304634. Dph2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Diphthamide biosynthesis protein 2PRO_0000307892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei435 – 4351PhosphothreonineBy similarity
Modified residuei446 – 4461PhosphoserineBy similarity
Modified residuei456 – 4561PhosphoserineBy similarity
Modified residuei467 – 4671PhosphothreonineBy similarity
Modified residuei488 – 4881PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ568Y2.
PRIDEiQ568Y2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019735.
GenevisibleiQ568Y2. RN.

Interactioni

Subunit structurei

Interacts with DPH1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026739.

Structurei

3D structure databases

ProteinModelPortaliQ568Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DPH1/DPH2 family. DPH2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2648. Eukaryota.
COG1736. LUCA.
GeneTreeiENSGT00550000075105.
HOGENOMiHOG000182223.
HOVERGENiHBG107823.
InParanoidiQ568Y2.
KOiK17866.
OMAiCCPDTGQ.
OrthoDBiEOG091G09K9.
PhylomeDBiQ568Y2.
TreeFamiTF313832.

Family and domain databases

InterProiIPR010014. DHP2_eu.
IPR016435. DPH1/DPH2.
[Graphical view]
PANTHERiPTHR10762. PTHR10762. 1 hit.
PfamiPF01866. Diphthamide_syn. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00322. diphth2_R. 1 hit.
TIGR00272. DPH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q568Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTFSSPAE AALQREAGVP GQFTPPEDLD RVYELERVTR FICDLGCQRV
60 70 80 90 100
ALQFPDQLLG DAGAVAARLE EVTGSKMFIL GDTAYGSCCV DVLGAEQAGA
110 120 130 140 150
QALVHFGPAC LSPPASLLPI TFVLGRRPVA LELCAKAFEA QNPDPTALVV
160 170 180 190 200
LLSEPACAHA LEPLATLLRP KYQDLLISSP ALPLPVGSLS SQPESLERFG
210 220 230 240 250
RRFPLNPGRS LEEYGAFYVG ASQASSDPNL DPDLSRLLLG WTPGRPFFSC
260 270 280 290 300
CPDTGQTQDQ GAKAGRLRAR RLYLVERARD ARVVGLLVGT LGVAQHLEAL
310 320 330 340 350
AHLRKLTEAA GKRSYVLALG KPTPAKLANF PEMDVFVLLA CPLGALTLQP
360 370 380 390 400
SGGFFRPILT PCELEAACNP AWPPPGLAPH LTHYAELLPG SPFHVPLPPP
410 420 430 440 450
ESELWDTPDV SLISGELRPP PPWKSSDDTK CSALTPRPQL ELAESSPAAS
460 470 480
FLSSRSWQGL EPRLGQTPVK EAVQGRRGIA IAYEDEGSS
Length:489
Mass (Da):52,325
Last modified:May 10, 2005 - v1
Checksum:i8C8F0F4720E9C14F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092656 mRNA. Translation: AAH92656.1.
RefSeqiNP_001015007.1. NM_001015007.1.
UniGeneiRn.49365.

Genome annotation databases

EnsembliENSRNOT00000026739; ENSRNOP00000026739; ENSRNOG00000019735.
GeneIDi298452.
KEGGirno:298452.
UCSCiRGD:1304634. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092656 mRNA. Translation: AAH92656.1.
RefSeqiNP_001015007.1. NM_001015007.1.
UniGeneiRn.49365.

3D structure databases

ProteinModelPortaliQ568Y2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026739.

Proteomic databases

PaxDbiQ568Y2.
PRIDEiQ568Y2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026739; ENSRNOP00000026739; ENSRNOG00000019735.
GeneIDi298452.
KEGGirno:298452.
UCSCiRGD:1304634. rat.

Organism-specific databases

CTDi1802.
RGDi1304634. Dph2.

Phylogenomic databases

eggNOGiKOG2648. Eukaryota.
COG1736. LUCA.
GeneTreeiENSGT00550000075105.
HOGENOMiHOG000182223.
HOVERGENiHBG107823.
InParanoidiQ568Y2.
KOiK17866.
OMAiCCPDTGQ.
OrthoDBiEOG091G09K9.
PhylomeDBiQ568Y2.
TreeFamiTF313832.

Enzyme and pathway databases

UniPathwayiUPA00559.
ReactomeiR-RNO-5358493. Synthesis of diphthamide-EEF2.

Miscellaneous databases

PROiQ568Y2.

Gene expression databases

BgeeiENSRNOG00000019735.
GenevisibleiQ568Y2. RN.

Family and domain databases

InterProiIPR010014. DHP2_eu.
IPR016435. DPH1/DPH2.
[Graphical view]
PANTHERiPTHR10762. PTHR10762. 1 hit.
PfamiPF01866. Diphthamide_syn. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00322. diphth2_R. 1 hit.
TIGR00272. DPH2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPH2_RAT
AccessioniPrimary (citable) accession number: Q568Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.