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Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Gene

hddc3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ppGpp hydrolyzing enzyme involved in starvation response.By similarity

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361ManganeseBy similarity
Metal bindingi62 – 621ManganeseBy similarity
Metal bindingi63 – 631ManganeseBy similarity
Active sitei66 – 661NucleophileBy similarity
Active sitei67 – 671NucleophileBy similarity
Metal bindingi123 – 1231ManganeseBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
Alternative name(s):
HD domain-containing protein 3
Metazoan SpoT homolog 1
Short name:
MESH1
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:hddc3
Synonyms:Mesh1
ORF Names:zgc:110184
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050417-377. hddc3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1PRO_0000263112Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000033279.

Structurei

3D structure databases

ProteinModelPortaliQ568P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 12896HDAdd
BLAST

Sequence similaritiesi

Belongs to the MESH1 family.Curated
Contains 1 HD domain.Curated

Phylogenomic databases

eggNOGiCOG0317.
HOVERGENiHBG081594.
InParanoidiQ568P1.
KOiK01139.
PhylomeDBiQ568P1.

Family and domain databases

InterProiIPR003607. HD/PDEase_dom.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q568P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCSSTAVLL ETVNFAAEKH RNQRHKDPEG TPYINHPIGV ARILSHEGEI
60 70 80 90 100
TDVEVIQAAL LHDTVEDTDT TFEELESVFG ATVARIVQGV TDDKSLPKAE
110 120 130 140 150
RERQQVEHAP HCSHQAKLVK LADKLYNLRD LNRCTPEGWS AQRVQEYFEW
160 170 180
ASQVVKGLRG TNAAIEEKLQ QLFLERGVKL
Length:180
Mass (Da):20,296
Last modified:May 10, 2005 - v1
Checksum:i6CC9689FCDE3E8DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092780 mRNA. Translation: AAH92780.1.
RefSeqiNP_001017835.1. NM_001017835.1.
UniGeneiDr.85187.

Genome annotation databases

GeneIDi550533.
KEGGidre:550533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092780 mRNA. Translation: AAH92780.1.
RefSeqiNP_001017835.1. NM_001017835.1.
UniGeneiDr.85187.

3D structure databases

ProteinModelPortaliQ568P1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000033279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi550533.
KEGGidre:550533.

Organism-specific databases

CTDi374659.
ZFINiZDB-GENE-050417-377. hddc3.

Phylogenomic databases

eggNOGiCOG0317.
HOVERGENiHBG081594.
InParanoidiQ568P1.
KOiK01139.
PhylomeDBiQ568P1.

Miscellaneous databases

NextBioi20879774.
PROiQ568P1.

Family and domain databases

InterProiIPR003607. HD/PDEase_dom.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMESH1_DANRE
AccessioniPrimary (citable) accession number: Q568P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 10, 2005
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.