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Q568P1

- MESH1_DANRE

UniProt

Q568P1 - MESH1_DANRE

Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Gene

hddc3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    ppGpp hydrolyzing enzyme involved in starvation response.By similarity

    Catalytic activityi

    Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

    Cofactori

    Manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi36 – 361ManganeseBy similarity
    Metal bindingi62 – 621ManganeseBy similarity
    Metal bindingi63 – 631ManganeseBy similarity
    Active sitei66 – 661NucleophileBy similarity
    Active sitei67 – 671NucleophileBy similarity
    Metal bindingi123 – 1231ManganeseBy similarity

    GO - Molecular functioni

    1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
    Alternative name(s):
    HD domain-containing protein 3
    Metazoan SpoT homolog 1
    Short name:
    MESH1
    Penta-phosphate guanosine-3'-pyrophosphohydrolase
    Short name:
    (ppGpp)ase
    Gene namesi
    Name:hddc3
    Synonyms:Mesh1
    ORF Names:zgc:110184
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-050417-377. hddc3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 180180Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1PRO_0000263112Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000033279.

    Structurei

    3D structure databases

    ProteinModelPortaliQ568P1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 12896HDAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MESH1 family.Curated
    Contains 1 HD domain.Curated

    Phylogenomic databases

    eggNOGiCOG0317.
    HOVERGENiHBG081594.
    InParanoidiQ568P1.
    KOiK01139.
    PhylomeDBiQ568P1.

    Family and domain databases

    InterProiIPR003607. HD/PDEase_dom.
    [Graphical view]
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q568P1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNCSSTAVLL ETVNFAAEKH RNQRHKDPEG TPYINHPIGV ARILSHEGEI    50
    TDVEVIQAAL LHDTVEDTDT TFEELESVFG ATVARIVQGV TDDKSLPKAE 100
    RERQQVEHAP HCSHQAKLVK LADKLYNLRD LNRCTPEGWS AQRVQEYFEW 150
    ASQVVKGLRG TNAAIEEKLQ QLFLERGVKL 180
    Length:180
    Mass (Da):20,296
    Last modified:May 10, 2005 - v1
    Checksum:i6CC9689FCDE3E8DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC092780 mRNA. Translation: AAH92780.1.
    RefSeqiNP_001017835.1. NM_001017835.1.
    UniGeneiDr.85187.

    Genome annotation databases

    GeneIDi550533.
    KEGGidre:550533.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC092780 mRNA. Translation: AAH92780.1 .
    RefSeqi NP_001017835.1. NM_001017835.1.
    UniGenei Dr.85187.

    3D structure databases

    ProteinModelPortali Q568P1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000033279.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 550533.
    KEGGi dre:550533.

    Organism-specific databases

    CTDi 374659.
    ZFINi ZDB-GENE-050417-377. hddc3.

    Phylogenomic databases

    eggNOGi COG0317.
    HOVERGENi HBG081594.
    InParanoidi Q568P1.
    KOi K01139.
    PhylomeDBi Q568P1.

    Miscellaneous databases

    NextBioi 20879774.
    PROi Q568P1.

    Family and domain databases

    InterProi IPR003607. HD/PDEase_dom.
    [Graphical view ]
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiMESH1_DANRE
    AccessioniPrimary (citable) accession number: Q568P1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3