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Q568P1 (MESH1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

EC=3.1.7.2
Alternative name(s):
HD domain-containing protein 3
Metazoan SpoT homolog 1
Short name=MESH1
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name=(ppGpp)ase
Gene names
Name:hddc3
Synonyms:Mesh1
ORF Names:zgc:110184
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

ppGpp hydrolyzing enzyme involved in starvation response By similarity.

Catalytic activity

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactor

Manganese By similarity.

Sequence similarities

Belongs to the MESH1 family.

Contains 1 HD domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 180180Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
PRO_0000263112

Regions

Domain33 – 12896HD

Sites

Active site661Nucleophile By similarity
Active site671Nucleophile By similarity
Metal binding361Manganese By similarity
Metal binding621Manganese By similarity
Metal binding631Manganese By similarity
Metal binding1231Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q568P1 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 6CC9689FCDE3E8DE

FASTA18020,296
        10         20         30         40         50         60 
MNCSSTAVLL ETVNFAAEKH RNQRHKDPEG TPYINHPIGV ARILSHEGEI TDVEVIQAAL 

        70         80         90        100        110        120 
LHDTVEDTDT TFEELESVFG ATVARIVQGV TDDKSLPKAE RERQQVEHAP HCSHQAKLVK 

       130        140        150        160        170        180 
LADKLYNLRD LNRCTPEGWS AQRVQEYFEW ASQVVKGLRG TNAAIEEKLQ QLFLERGVKL 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC092780 mRNA. Translation: AAH92780.1.
RefSeqNP_001017835.1. NM_001017835.1.
UniGeneDr.85187.

3D structure databases

ProteinModelPortalQ568P1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000033279.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID550533.
KEGGdre:550533.

Organism-specific databases

CTD374659.
ZFINZDB-GENE-050417-377. hddc3.

Phylogenomic databases

eggNOGCOG0317.
HOVERGENHBG081594.
InParanoidQ568P1.
KOK01139.
PhylomeDBQ568P1.

Family and domain databases

InterProIPR003607. HD/PDEase_dom.
[Graphical view]
SMARTSM00471. HDc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20879774.
PROQ568P1.

Entry information

Entry nameMESH1_DANRE
AccessionPrimary (citable) accession number: Q568P1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families