SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q568P1

- MESH1_DANRE

UniProt

Q568P1 - MESH1_DANRE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Gene
hddc3, Mesh1, zgc:110184
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

ppGpp hydrolyzing enzyme involved in starvation response By similarity.

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Manganese By similarity
Metal bindingi62 – 621Manganese By similarity
Metal bindingi63 – 631Manganese By similarity
Active sitei66 – 661Nucleophile By similarity
Active sitei67 – 671Nucleophile By similarity
Metal bindingi123 – 1231Manganese By similarity

GO - Molecular functioni

  1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
Alternative name(s):
HD domain-containing protein 3
Metazoan SpoT homolog 1
Short name:
MESH1
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:hddc3
Synonyms:Mesh1
ORF Names:zgc:110184
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050417-377. hddc3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1PRO_0000263112Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000033279.

Structurei

3D structure databases

ProteinModelPortaliQ568P1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 12896HDAdd
BLAST

Sequence similaritiesi

Belongs to the MESH1 family.
Contains 1 HD domain.

Phylogenomic databases

eggNOGiCOG0317.
HOVERGENiHBG081594.
InParanoidiQ568P1.
KOiK01139.
PhylomeDBiQ568P1.

Family and domain databases

InterProiIPR003607. HD/PDEase_dom.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q568P1-1 [UniParc]FASTAAdd to Basket

« Hide

MNCSSTAVLL ETVNFAAEKH RNQRHKDPEG TPYINHPIGV ARILSHEGEI    50
TDVEVIQAAL LHDTVEDTDT TFEELESVFG ATVARIVQGV TDDKSLPKAE 100
RERQQVEHAP HCSHQAKLVK LADKLYNLRD LNRCTPEGWS AQRVQEYFEW 150
ASQVVKGLRG TNAAIEEKLQ QLFLERGVKL 180
Length:180
Mass (Da):20,296
Last modified:May 10, 2005 - v1
Checksum:i6CC9689FCDE3E8DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC092780 mRNA. Translation: AAH92780.1.
RefSeqiNP_001017835.1. NM_001017835.1.
UniGeneiDr.85187.

Genome annotation databases

GeneIDi550533.
KEGGidre:550533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC092780 mRNA. Translation: AAH92780.1 .
RefSeqi NP_001017835.1. NM_001017835.1.
UniGenei Dr.85187.

3D structure databases

ProteinModelPortali Q568P1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000033279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 550533.
KEGGi dre:550533.

Organism-specific databases

CTDi 374659.
ZFINi ZDB-GENE-050417-377. hddc3.

Phylogenomic databases

eggNOGi COG0317.
HOVERGENi HBG081594.
InParanoidi Q568P1.
KOi K01139.
PhylomeDBi Q568P1.

Miscellaneous databases

NextBioi 20879774.
PROi Q568P1.

Family and domain databases

InterProi IPR003607. HD/PDEase_dom.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMESH1_DANRE
AccessioniPrimary (citable) accession number: Q568P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi