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Q568P1

- MESH1_DANRE

UniProt

Q568P1 - MESH1_DANRE

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Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Gene

hddc3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

ppGpp hydrolyzing enzyme involved in starvation response.By similarity

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361ManganeseBy similarity
Metal bindingi62 – 621ManganeseBy similarity
Metal bindingi63 – 631ManganeseBy similarity
Active sitei66 – 661NucleophileBy similarity
Active sitei67 – 671NucleophileBy similarity
Metal bindingi123 – 1231ManganeseBy similarity

GO - Molecular functioni

  1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
Alternative name(s):
HD domain-containing protein 3
Metazoan SpoT homolog 1
Short name:
MESH1
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:hddc3
Synonyms:Mesh1
ORF Names:zgc:110184
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050417-377. hddc3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1PRO_0000263112Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000033279.

Structurei

3D structure databases

ProteinModelPortaliQ568P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 12896HDAdd
BLAST

Sequence similaritiesi

Belongs to the MESH1 family.Curated
Contains 1 HD domain.Curated

Phylogenomic databases

eggNOGiCOG0317.
HOVERGENiHBG081594.
InParanoidiQ568P1.
KOiK01139.
PhylomeDBiQ568P1.

Family and domain databases

InterProiIPR003607. HD/PDEase_dom.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q568P1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNCSSTAVLL ETVNFAAEKH RNQRHKDPEG TPYINHPIGV ARILSHEGEI
60 70 80 90 100
TDVEVIQAAL LHDTVEDTDT TFEELESVFG ATVARIVQGV TDDKSLPKAE
110 120 130 140 150
RERQQVEHAP HCSHQAKLVK LADKLYNLRD LNRCTPEGWS AQRVQEYFEW
160 170 180
ASQVVKGLRG TNAAIEEKLQ QLFLERGVKL
Length:180
Mass (Da):20,296
Last modified:May 10, 2005 - v1
Checksum:i6CC9689FCDE3E8DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092780 mRNA. Translation: AAH92780.1.
RefSeqiNP_001017835.1. NM_001017835.1.
UniGeneiDr.85187.

Genome annotation databases

GeneIDi550533.
KEGGidre:550533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092780 mRNA. Translation: AAH92780.1 .
RefSeqi NP_001017835.1. NM_001017835.1.
UniGenei Dr.85187.

3D structure databases

ProteinModelPortali Q568P1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000033279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 550533.
KEGGi dre:550533.

Organism-specific databases

CTDi 374659.
ZFINi ZDB-GENE-050417-377. hddc3.

Phylogenomic databases

eggNOGi COG0317.
HOVERGENi HBG081594.
InParanoidi Q568P1.
KOi K01139.
PhylomeDBi Q568P1.

Miscellaneous databases

NextBioi 20879774.
PROi Q568P1.

Family and domain databases

InterProi IPR003607. HD/PDEase_dom.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMESH1_DANRE
AccessioniPrimary (citable) accession number: Q568P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 10, 2005
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3