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Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Gene

hddc3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ppGpp hydrolyzing enzyme involved in starvation response.By similarity

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36ManganeseBy similarity1
Metal bindingi62ManganeseBy similarity1
Metal bindingi63ManganeseBy similarity1
Active sitei66NucleophileBy similarity1
Active sitei67NucleophileBy similarity1
Metal bindingi123ManganeseBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
Alternative name(s):
HD domain-containing protein 3
Metazoan SpoT homolog 1
Short name:
MESH1
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:hddc3
Synonyms:Mesh1
ORF Names:zgc:110184
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050417-377. hddc3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002631121 – 180Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1Add BLAST180

Proteomic databases

PaxDbiQ568P1.
PRIDEiQ568P1.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000033279.

Structurei

3D structure databases

ProteinModelPortaliQ568P1.
SMRiQ568P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 128HDPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the MESH1 family.Curated

Phylogenomic databases

eggNOGiKOG1157. Eukaryota.
COG0317. LUCA.
HOVERGENiHBG081594.
InParanoidiQ568P1.
KOiK21138.
PhylomeDBiQ568P1.

Family and domain databases

CDDicd00077. HDc. 1 hit.
InterProiView protein in InterPro
IPR003607. HD/PDEase_dom.
PfamiView protein in Pfam
PF13328. HD_4. 1 hit.
SMARTiView protein in SMART
SM00471. HDc. 1 hit.
PROSITEiView protein in PROSITE
PS51831. HD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q568P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCSSTAVLL ETVNFAAEKH RNQRHKDPEG TPYINHPIGV ARILSHEGEI
60 70 80 90 100
TDVEVIQAAL LHDTVEDTDT TFEELESVFG ATVARIVQGV TDDKSLPKAE
110 120 130 140 150
RERQQVEHAP HCSHQAKLVK LADKLYNLRD LNRCTPEGWS AQRVQEYFEW
160 170 180
ASQVVKGLRG TNAAIEEKLQ QLFLERGVKL
Length:180
Mass (Da):20,296
Last modified:May 10, 2005 - v1
Checksum:i6CC9689FCDE3E8DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092780 mRNA. Translation: AAH92780.1.
RefSeqiNP_001017835.1. NM_001017835.1.
UniGeneiDr.85187.

Genome annotation databases

GeneIDi550533.
KEGGidre:550533.

Similar proteinsi

Entry informationi

Entry nameiMESH1_DANRE
AccessioniPrimary (citable) accession number: Q568P1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 10, 2005
Last modified: September 27, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families