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Q568I2 (ACER1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alkaline ceramidase 1

Short name=AlkCDase 1
Short name=Alkaline CDase 1
EC=3.5.1.23
Alternative name(s):
Acylsphingosine deacylase 3
N-acylsphingosine amidohydrolase 3
Gene names
Name:acer1
Synonyms:asah3
ORF Names:zgc:110285
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0 By similarity.

Catalytic activity

N-acylsphingosine + H2O = a carboxylate + sphingosine.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the alkaline ceramidase family.

Ontologies

Keywords
   Biological processLipid metabolism
   Cellular componentEndoplasmic reticulum
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processceramide metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionceramidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Alkaline ceramidase 1
PRO_0000247747

Regions

Topological domain1 – 2727Lumenal Potential
Transmembrane28 – 4821Helical; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7721Helical; Potential
Topological domain78 – 836Lumenal Potential
Transmembrane84 – 10421Helical; Potential
Topological domain105 – 11612Cytoplasmic Potential
Transmembrane117 – 13620Helical; Potential
Topological domain137 – 1393Lumenal Potential
Transmembrane140 – 16021Helical; Potential
Topological domain161 – 1677Cytoplasmic Potential
Transmembrane168 – 18821Helical; Potential
Topological domain189 – 20517Lumenal Potential
Transmembrane206 – 22621Helical; Potential
Topological domain227 – 26640Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q568I2 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 0619331570BE647C

FASTA26630,908
        10         20         30         40         50         60 
MAGVFSYESS EVDWCEDNYK HSENVVEYFN TMSSFIFFVI SPIMLYLLHP YAKERNLAVH 

        70         80         90        100        110        120 
LVWIMMVFVG IFSMYFHMTL SFMGQMLDEL SILWVLAIGY SLWFPRKHFP SFVKDRTSFA 

       130        140        150        160        170        180 
RLVLTITIIS TLSSFVKPTA NAYALNCFAI HILYSLFVEL KSCTDERVLR LAWASIGLWV 

       190        200        210        220        230        240 
LAISCWISDR FGCSFWQKLD FCYLHGIWHI LIVMATAYAS TLIAYLDASQ EIPYSLPDLQ 

       250        260 
YWPRNNWAIG LPYIVLKGTN TTRKTC 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC092849 mRNA. Translation: AAH92849.1.
IPIIPI00499405.
RefSeqNP_001017603.1. NM_001017603.1.
UniGeneDr.80506.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ568I2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID550266.
KEGGdre:550266.

Organism-specific databases

CTD125981.
ZFINZDB-GENE-050417-70. acer1.

Phylogenomic databases

eggNOGfiNOG10726.
GeneTreeENSGT00390000004916.
InParanoidQ568I2.
OrthoDBEOG4XD3RW.
PhylomeDBQ568I2.

Gene expression databases

ArrayExpressQ568I2.
BgeeQ568I2.

Family and domain databases

InterProIPR008901. Ceramidase.
[Graphical view]
KOK01441.
PfamPF05875. Ceramidase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACER1_DANRE
AccessionPrimary (citable) accession number: Q568I2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 10, 2005
Last modified: November 16, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families