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Reviewed, UniProtKB/Swiss-Prot Q568I2 (ACER1_DANRE)

Last modified February 9, 2010. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Alkaline ceramidase 1
      Short name=Alkaline CDase 1
      Short name=AlkCDase 1
    EC=3.5.1.23
Alternative name(s):
    N-acylsphingosine amidohydrolase 3
    Acylsphingosine deacylase 3
Gene names
Name: acer1
Synonyms: asah3
ORF Names: zgc:110285
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0 By similarity.

Catalytic activity

N-acylsphingosine + H2O = a carboxylate + sphingosine.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the alkaline ceramidase family.

Ontologies

Keywords
   Biological processLipid metabolism
   Cellular componentEndoplasmic reticulum
Membrane
   DomainTransmembrane
   Molecular functionHydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processceramide metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentGolgi membrane

Inferred from electronic annotation. Source: InterPro

endoplasmic reticulum membrane

Inferred from electronic annotation. Source: InterPro

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionceramidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Alkaline ceramidase 1
PRO_0000247747

Regions

Transmembrane28 – 4821 Potential
Transmembrane57 – 7721 Potential
Transmembrane84 – 10421 Potential
Transmembrane117 – 13620 Potential
Transmembrane140 – 16021 Potential
Transmembrane168 – 18821 Potential
Transmembrane206 – 22621 Potential

Amino acid modifications

Glycosylation2601N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q568I2-1 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 0619331570BE647C

FASTA26630,908
        10         20         30         40         50         60 
MAGVFSYESS EVDWCEDNYK HSENVVEYFN TMSSFIFFVI SPIMLYLLHP YAKERNLAVH 

        70         80         90        100        110        120 
LVWIMMVFVG IFSMYFHMTL SFMGQMLDEL SILWVLAIGY SLWFPRKHFP SFVKDRTSFA 

       130        140        150        160        170        180 
RLVLTITIIS TLSSFVKPTA NAYALNCFAI HILYSLFVEL KSCTDERVLR LAWASIGLWV 

       190        200        210        220        230        240 
LAISCWISDR FGCSFWQKLD FCYLHGIWHI LIVMATAYAS TLIAYLDASQ EIPYSLPDLQ 

       250        260 
YWPRNNWAIG LPYIVLKGTN TTRKTC 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC092849 mRNA. Translation: AAH92849.1.
IPIIPI00499405.
RefSeqNP_001017603.1.
UniGeneDr.80506

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ568I2.

Genome annotation databases

EnsemblENSDART00000023797; ENSDARP00000022832; ENSDARG00000010347; Danio rerio. [Genome view]
GeneID550266.
KEGGdre:550266.

Organism-specific databases

CTD550266.
ZFINZDB-GENE-050417-70. acer1.

Phylogenomic databases

eggNOGfiNOG10726.
HOVERGENQ568I2.
InParanoidQ568I2.
PhylomeDBQ568I2.

Enzyme and pathway databases

BRENDA3.5.1.23. 96826.

Gene expression databases

ArrayExpressQ568I2.
BgeeQ568I2.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameACER1_DANRE
AccessionPrimary (citable) accession number: Q568I2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 10, 2005
Last modified: February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents