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Protein

BRISC and BRCA1-A complex member 2

Gene

babam2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the brca1-bard1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processApoptosis, Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
BRISC and BRCA1-A complex member 2
Alternative name(s):
BRCA1-A complex subunit BRE
BRCA1/BRCA2-containing complex subunit 45
Brain and reproductive organ-expressed protein
Gene namesi
Name:babam2
Synonyms:bre
ORF Names:zgc:110368
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050417-299. babam2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003739361 – 386BRISC and BRCA1-A complex member 2Add BLAST386

Proteomic databases

PaxDbiQ568D5.
PRIDEiQ568D5.

Interactioni

Subunit structurei

Component of the ARISC complex, at least composed of uimc1/rap80, abraxas1, brcc3/brcc36, BABAM2 and babam1/nba1. Component of the BRCA1-A complex, at least composed of brca1, bard1, uimc1/rap80, abraxas1, brcc3/brcc36, BABAM2 and babam1/nba1. In the BRCA1-A complex, interacts directly with abraxas1, brcc3/brcc36 and babam1/nba1. Binds polyubiquitin. Component of the BRISC complex, at least composed of abraxas2, brcc3/brcc36, BABAM2 and babam1/nba1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000056741.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 150UEV-like 1Add BLAST118
Regioni278 – 367UEV-like 2Add BLAST90

Domaini

Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.By similarity

Sequence similaritiesi

Belongs to the BABAM2 family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IFRG. Eukaryota.
ENOG410Y1T7. LUCA.
HOGENOMiHOG000095259.
InParanoidiQ568D5.
KOiK12173.
PhylomeDBiQ568D5.

Family and domain databases

InterProiView protein in InterPro
IPR010358. BRE.
PANTHERiPTHR15189:SF8. PTHR15189:SF8. 1 hit.
PfamiView protein in Pfam
PF06113. BRE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q568D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLSPELAL SRISPELRPL LCSIVRNGRV GLDSSSCLRI TDLKSGCTSL
60 70 80 90 100
MPGPCCDRFK LHIPYAGETL KWDIIFNARD PELPPDFIFG EDADFLPEPS
110 120 130 140 150
ELPNLVSWDS GKPECLLLLV KEMLQQYHQY QCQRLRDSSR LLFEYDSLLE
160 170 180 190 200
DPNYGRNMEI YAGRKNSWTG EFSARFLLKL PVDFSNIPIY LLKDTALDPG
210 220 230 240 250
EDVALLSVSF EDAEATQVFP KLYLSPSIEH ALGGSSALHI PAFPSGGCLI
260 270 280 290 300
DYVPQVCQLL TNKVQYVIQG YHKRREYIAA FLSHFGMGVV EYDAVGFTKL
310 320 330 340 350
TLLLMWKDFC FLVHVDLPLY FPRDQPTLTF QSIYHFTSSG QLYSQVQKSY
360 370 380
PYSPRWDGNE MAKRAKAYFK SFIPQFQEGA FANGKL
Length:386
Mass (Da):43,829
Last modified:May 10, 2005 - v1
Checksum:i431614244E661EA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092902 mRNA. Translation: AAH92902.1.
RefSeqiNP_001017777.1. NM_001017777.1.
UniGeneiDr.118971.

Genome annotation databases

GeneIDi550474.
KEGGidre:550474.

Similar proteinsi

Entry informationi

Entry nameiBABA2_DANRE
AccessioniPrimary (citable) accession number: Q568D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 10, 2005
Last modified: September 27, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families