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Protein

BRCA1-A complex subunit BRE

Gene

bre

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the brca1-bard1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
BRCA1-A complex subunit BRE
Alternative name(s):
BRCA1/BRCA2-containing complex subunit 45
Brain and reproductive organ-expressed protein
Gene namesi
Name:bre
ORF Names:zgc:110368
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050417-299. bre.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Localizes at sites of DNA damage at double-strand breaks (DSBs).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386BRCA1-A complex subunit BREPRO_0000373936Add
BLAST

Proteomic databases

PaxDbiQ568D5.

Interactioni

Subunit structurei

Component of the ARISC complex, at least composed of uimc1/rap80, fam175a/Abraxas, brcc3/brcc36, bre/brcc45 and babam1/nba1. Component of the BRCA1-A complex, at least composed of brca1, bard1, uimc1/rap80, fam175a/Abraxas, brcc3/brcc36, bre/brcc45 and babam1/nba1. In the BRCA1-A complex, interacts directly with fam175a/Abraxas, brcc3/brcc36 and babam1/nba1. Binds polyubiquitin. Component of the BRISC complex, at least composed of fam175b/abro1, brcc3/brcc36, bre/brcc45 and babam1/nba1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000056741.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 150118UEV-like 1Add
BLAST
Regioni278 – 36790UEV-like 2Add
BLAST

Domaini

Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.By similarity

Sequence similaritiesi

Belongs to the BRE family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IFRG. Eukaryota.
ENOG410Y1T7. LUCA.
HOGENOMiHOG000095259.
InParanoidiQ568D5.
KOiK12173.
PhylomeDBiQ568D5.

Family and domain databases

InterProiIPR010358. Brain/reproduct-express_prot.
[Graphical view]
PfamiPF06113. BRE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q568D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLSPELAL SRISPELRPL LCSIVRNGRV GLDSSSCLRI TDLKSGCTSL
60 70 80 90 100
MPGPCCDRFK LHIPYAGETL KWDIIFNARD PELPPDFIFG EDADFLPEPS
110 120 130 140 150
ELPNLVSWDS GKPECLLLLV KEMLQQYHQY QCQRLRDSSR LLFEYDSLLE
160 170 180 190 200
DPNYGRNMEI YAGRKNSWTG EFSARFLLKL PVDFSNIPIY LLKDTALDPG
210 220 230 240 250
EDVALLSVSF EDAEATQVFP KLYLSPSIEH ALGGSSALHI PAFPSGGCLI
260 270 280 290 300
DYVPQVCQLL TNKVQYVIQG YHKRREYIAA FLSHFGMGVV EYDAVGFTKL
310 320 330 340 350
TLLLMWKDFC FLVHVDLPLY FPRDQPTLTF QSIYHFTSSG QLYSQVQKSY
360 370 380
PYSPRWDGNE MAKRAKAYFK SFIPQFQEGA FANGKL
Length:386
Mass (Da):43,829
Last modified:May 10, 2005 - v1
Checksum:i431614244E661EA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092902 mRNA. Translation: AAH92902.1.
RefSeqiNP_001017777.1. NM_001017777.1.
UniGeneiDr.118971.

Genome annotation databases

GeneIDi550474.
KEGGidre:550474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092902 mRNA. Translation: AAH92902.1.
RefSeqiNP_001017777.1. NM_001017777.1.
UniGeneiDr.118971.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000056741.

Proteomic databases

PaxDbiQ568D5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi550474.
KEGGidre:550474.

Organism-specific databases

CTDi9577.
ZFINiZDB-GENE-050417-299. bre.

Phylogenomic databases

eggNOGiENOG410IFRG. Eukaryota.
ENOG410Y1T7. LUCA.
HOGENOMiHOG000095259.
InParanoidiQ568D5.
KOiK12173.
PhylomeDBiQ568D5.

Miscellaneous databases

NextBioi20879717.
PROiQ568D5.

Family and domain databases

InterProiIPR010358. Brain/reproduct-express_prot.
[Graphical view]
PfamiPF06113. BRE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiBRE_DANRE
AccessioniPrimary (citable) accession number: Q568D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 10, 2005
Last modified: April 13, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.