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Protein

Protein UshA

Gene

ushA

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell.By similarity

Catalytic activityi

UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactori

Co2+By similarityNote: Divalent metal cations. Most likely Co2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Divalent metal cation 1By similarity1
Metal bindingi43Divalent metal cation 1By similarity1
Metal bindingi84Divalent metal cation 1By similarity1
Metal bindingi84Divalent metal cation 2By similarity1
Metal bindingi116Divalent metal cation 2By similarity1
Sitei117Transition state stabilizerBy similarity1
Sitei120Transition state stabilizerBy similarity1
Metal bindingi217Divalent metal cation 2By similarity1
Metal bindingi252Divalent metal cation 2By similarity1
Metal bindingi254Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCobalt, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UshA
Including the following 2 domains:
UDP-sugar hydrolase (EC:3.6.1.45)
Alternative name(s):
UDP-sugar diphosphatase
UDP-sugar pyrophosphatase
5'-nucleotidase (EC:3.1.3.5)
Short name:
5'-NT
Gene namesi
Name:ushA
Ordered Locus Names:YE3066
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000003426 – 550Protein UshAAdd BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi258 ↔ 275By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ56878

Interactioni

Protein-protein interaction databases

STRINGi393305.YE3066

Structurei

3D structure databases

ProteinModelPortaliQ56878
SMRiQ56878
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni375 – 379Substrate bindingBy similarity5
Regioni498 – 504Substrate bindingBy similarity7

Sequence similaritiesi

Belongs to the 5'-nucleotidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105CGH Bacteria
COG0737 LUCA
HOGENOMiHOG000247216
KOiK11751
OMAiCRFQECN
OrthoDBiPOG091H03VR

Family and domain databases

Gene3Di3.60.21.10, 1 hit
3.90.780.10, 1 hit
InterProiView protein in InterPro
IPR008334 5'-Nucleotdase_C
IPR036907 5'-Nucleotdase_C_sf
IPR006146 5'-Nucleotdase_CS
IPR006179 5_nucleotidase/apyrase
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PANTHERiPTHR11575 PTHR11575, 1 hit
PfamiView protein in Pfam
PF02872 5_nucleotid_C, 1 hit
PF00149 Metallophos, 1 hit
PRINTSiPR01607 APYRASEFAMLY
SUPFAMiSSF55816 SSF55816, 1 hit
PROSITEiView protein in PROSITE
PS00785 5_NUCLEOTIDASE_1, 1 hit
PS00786 5_NUCLEOTIDASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56878-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFSLSTTAA ALAVSLAFAP GWAVAWEKDK TYDITILHTN DHHGHFWQND
60 70 80 90 100
HGEYGLAAQK TLVDDIRKQV AAAGGSLLLL SGGDINTGVP ESDLQDAEPD
110 120 130 140 150
FRGMNLVGYD AMAIGNHEFD NPLSVLRQQE KWATFPLLSA NIYQKSTQQR
160 170 180 190 200
LFKPYALFDK QGVKIAVIGL TTDDTAKIGN PEYFTDIEFR VPATEAKQVV
210 220 230 240 250
EQLRKTEKPD IIIAATHMGH YDDGKHGSNA PGDVEMARSL PAGYLDMIVG
260 270 280 290 300
GHSQDPVCMA SENHKQADYV PGTPCAPDRQ NGTWIVQAHE WGKYVGRADF
310 320 330 340 350
KFRNGELKLV SYQLIPINLK KKVEKADGTS ERIFYTQEIA QDPSMLKLLT
360 370 380 390 400
PFEQQGKAQL DVKVGSVNGK LEGDRSKVRF EQTNLARLLL AAQMERAGAD
410 420 430 440 450
FAVMSGGGVR DSIDAGDITY KDVLKVQPFG NTLVYADMKG SEVEKYLAVV
460 470 480 490 500
ANKKVDSGAY AQFANVSLVA DGKGVSNVKI QGKPLDPNKT YRLATLNFNA
510 520 530 540 550
LGGDGYPKID TLPSYVNTGF IDAEVLKQYI EKHSPLDASQ YQPKGEIVYK
Length:550
Mass (Da):60,383
Last modified:March 20, 2007 - v3
Checksum:iE52BA3FD5A71ED61
GO

Sequence cautioni

The sequence AAC60782 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24V → A in AAC60782 (Ref. 2) Curated1
Sequence conflicti47W → C in AAC60782 (Ref. 2) Curated1
Sequence conflicti72 – 83AAGGS…LLSGG → RSRGKLVVALRW in AAC60782 (Ref. 2) CuratedAdd BLAST12
Sequence conflicti126Missing in AAC60782 (Ref. 2) Curated1
Sequence conflicti129 – 130QE → HQ in AAC60782 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA Translation: CAL13101.1
U46859 Genomic DNA Translation: AAC60782.1 Different initiation.
RefSeqiWP_011816863.1, NC_008800.1
YP_001007248.1, NC_008800.1

Genome annotation databases

EnsemblBacteriaiCAL13101; CAL13101; YE3066
GeneIDi4714553
KEGGiyen:YE3066
PATRICifig|393305.7.peg.3261

Similar proteinsi

Entry informationi

Entry nameiUSHA_YERE8
AccessioniPrimary (citable) accession number: Q56878
Secondary accession number(s): A1JN00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 20, 2007
Last modified: March 28, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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