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Q56878

- USHA_YERE8

UniProt

Q56878 - USHA_YERE8

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Protein

Protein UshA

Gene
ushA, YE3066
Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell By similarity.

Catalytic activityi

UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactori

Divalent cations. Most likely cobalt By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411Divalent metal cation 1 By similarity
Metal bindingi43 – 431Divalent metal cation 1 By similarity
Metal bindingi84 – 841Divalent metal cation 1 By similarity
Metal bindingi84 – 841Divalent metal cation 2 By similarity
Metal bindingi116 – 1161Divalent metal cation 2 By similarity
Sitei117 – 1171Transition state stabilizer By similarity
Sitei120 – 1201Transition state stabilizer By similarity
Metal bindingi217 – 2171Divalent metal cation 2 By similarity
Metal bindingi252 – 2521Divalent metal cation 2 By similarity
Metal bindingi254 – 2541Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 5'-nucleotidase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW
  4. UDP-sugar diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. nucleotide catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Cobalt, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UshA
Including the following 2 domains:
UDP-sugar hydrolase (EC:3.6.1.45)
Alternative name(s):
UDP-sugar diphosphatase
UDP-sugar pyrophosphatase
5'-nucleotidase (EC:3.1.3.5)
Short name:
5'-NT
Gene namesi
Name:ushA
Ordered Locus Names:YE3066
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000642: Chromosome

Subcellular locationi

Periplasm Reviewed prediction

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 550525Protein UshAPRO_0000000034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi258 ↔ 275 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ56878.

Interactioni

Protein-protein interaction databases

STRINGi393305.YE3066.

Structurei

3D structure databases

ProteinModelPortaliQ56878.
SMRiQ56878. Positions 26-547.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni375 – 3795Substrate binding By similarity
Regioni498 – 5047Substrate binding By similarity

Sequence similaritiesi

Belongs to the 5'-nucleotidase family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0737.
HOGENOMiHOG000247216.
KOiK11751.
OMAiPFQDKGK.
OrthoDBiEOG696BW0.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
3.90.780.10. 1 hit.
InterProiIPR008334. 5'-Nucleotdase_C.
IPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR11575. PTHR11575. 1 hit.
PfamiPF02872. 5_nucleotid_C. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR01607. APYRASEFAMLY.
SUPFAMiSSF55816. SSF55816. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiPS00785. 5_NUCLEOTIDASE_1. 1 hit.
PS00786. 5_NUCLEOTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56878-1 [UniParc]FASTAAdd to Basket

« Hide

MRFSLSTTAA ALAVSLAFAP GWAVAWEKDK TYDITILHTN DHHGHFWQND    50
HGEYGLAAQK TLVDDIRKQV AAAGGSLLLL SGGDINTGVP ESDLQDAEPD 100
FRGMNLVGYD AMAIGNHEFD NPLSVLRQQE KWATFPLLSA NIYQKSTQQR 150
LFKPYALFDK QGVKIAVIGL TTDDTAKIGN PEYFTDIEFR VPATEAKQVV 200
EQLRKTEKPD IIIAATHMGH YDDGKHGSNA PGDVEMARSL PAGYLDMIVG 250
GHSQDPVCMA SENHKQADYV PGTPCAPDRQ NGTWIVQAHE WGKYVGRADF 300
KFRNGELKLV SYQLIPINLK KKVEKADGTS ERIFYTQEIA QDPSMLKLLT 350
PFEQQGKAQL DVKVGSVNGK LEGDRSKVRF EQTNLARLLL AAQMERAGAD 400
FAVMSGGGVR DSIDAGDITY KDVLKVQPFG NTLVYADMKG SEVEKYLAVV 450
ANKKVDSGAY AQFANVSLVA DGKGVSNVKI QGKPLDPNKT YRLATLNFNA 500
LGGDGYPKID TLPSYVNTGF IDAEVLKQYI EKHSPLDASQ YQPKGEIVYK 550
Length:550
Mass (Da):60,383
Last modified:March 20, 2007 - v3
Checksum:iE52BA3FD5A71ED61
GO

Sequence cautioni

The sequence AAC60782.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241V → A in AAC60782. 1 Publication
Sequence conflicti47 – 471W → C in AAC60782. 1 Publication
Sequence conflicti72 – 8312AAGGS…LLSGG → RSRGKLVVALRW in AAC60782. 1 PublicationAdd
BLAST
Sequence conflicti126 – 1261Missing in AAC60782. 1 Publication
Sequence conflicti129 – 1302QE → HQ in AAC60782. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286415 Genomic DNA. Translation: CAL13101.1.
U46859 Genomic DNA. Translation: AAC60782.1. Different initiation.
RefSeqiYP_001007248.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL13101; CAL13101; YE3066.
GeneIDi4714553.
KEGGiyen:YE3066.
PATRICi18565839. VBIYerEnt11519_3261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286415 Genomic DNA. Translation: CAL13101.1 .
U46859 Genomic DNA. Translation: AAC60782.1 . Different initiation.
RefSeqi YP_001007248.1. NC_008800.1.

3D structure databases

ProteinModelPortali Q56878.
SMRi Q56878. Positions 26-547.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393305.YE3066.

Proteomic databases

PRIDEi Q56878.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL13101 ; CAL13101 ; YE3066 .
GeneIDi 4714553.
KEGGi yen:YE3066.
PATRICi 18565839. VBIYerEnt11519_3261.

Phylogenomic databases

eggNOGi COG0737.
HOGENOMi HOG000247216.
KOi K11751.
OMAi PFQDKGK.
OrthoDBi EOG696BW0.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
3.90.780.10. 1 hit.
InterProi IPR008334. 5'-Nucleotdase_C.
IPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
PANTHERi PTHR11575. PTHR11575. 1 hit.
Pfami PF02872. 5_nucleotid_C. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR01607. APYRASEFAMLY.
SUPFAMi SSF55816. SSF55816. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEi PS00785. 5_NUCLEOTIDASE_1. 1 hit.
PS00786. 5_NUCLEOTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 13174 / 8081.
  2. Zhang L., Toivanen P., Skurnik M.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-374.

Entry informationi

Entry nameiUSHA_YERE8
AccessioniPrimary (citable) accession number: Q56878
Secondary accession number(s): A1JN00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 20, 2007
Last modified: June 11, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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