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Protein

2-(S)-hydroxypropyl-CoM dehydrogenase

Gene

xecE

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of 2-(S)-hydroxyalkyl thioesters of CoM to 2-oxoalkyl thioesters of CoM. The enzyme highly specific for the S enantiomers.

Catalytic activityi

2-(S)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH.

Pathwayi: propylene degradation

This protein is involved in the pathway propylene degradation, which is part of Alkene metabolism.
View all proteins of this organism that are known to be involved in the pathway propylene degradation and in Alkene metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137SubstrateBy similarity1
Active sitei150Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13284
BRENDAi1.1.1.269 1641
UniPathwayiUPA00776

Names & Taxonomyi

Protein namesi
Recommended name:
2-(S)-hydroxypropyl-CoM dehydrogenase (EC:1.1.1.269)
Short name:
S-HPCDH
Alternative name(s):
Aliphatic epoxide carboxylation component IV
Gene namesi
Name:xecE
Ordered Locus Names:Xaut_4869
Encoded oniPlasmid pXAUT010 Publication
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
Proteomesi
  • UP000002417 Componenti: Plasmid pXAUT01

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547061 – 2492-(S)-hydroxypropyl-CoM dehydrogenaseAdd BLAST249

Proteomic databases

PRIDEiQ56841

Expressioni

Inductioni

By aliphatic and chlorinated alkenes.

Interactioni

Subunit structurei

Homodimer. Component IV of the aliphatic epoxide carboxylation complex together with components I, II and III.

Structurei

3D structure databases

ProteinModelPortaliQ56841
SMRiQ56841
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiPOG091H012M

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q56841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDAEVIAIT GGAAGIGLAV AHAAIRAGAR VALIDRDGAC AQRAAAEFGA
60 70 80 90 100
AAWGVGADVT DEAAITAAMA GAQRALGPLT GLVNNAGIAG FGSVHATEVE
110 120 130 140 150
TWSRIMAVNV TGTFLASKAA LFGMLERGRG AIVNFGSVAG LVGIPTMAAY
160 170 180 190 200
CAAKGAVVNL TRQMAADYSG RGIRVNVVCP GTVAGTDMGR QLLGTDCDPE
210 220 230 240
LEARRLAKYP MGRFGTPEDI AEAAVFLLST KAAFVTGSVL AVDGGMTAI
Length:249
Mass (Da):24,941
Last modified:November 1, 1996 - v1
Checksum:iB5E0B82C1D8D9782
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4A → N AA sequence (PubMed:9405410).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79863 Genomic DNA Translation: CAA56245.1
CP000782 Genomic DNA Translation: ABS70080.1
PIRiS47055
RefSeqiWP_011992984.1, NC_009717.1

Genome annotation databases

EnsemblBacteriaiABS70080; ABS70080; Xaut_4869
KEGGixau:Xaut_4869

Similar proteinsi

Entry informationi

Entry nameiHCDS_XANP2
AccessioniPrimary (citable) accession number: Q56841
Secondary accession number(s): A7IPY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Plasmid, Reference proteome

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