Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil domain-containing protein 93

Gene

CCDC93

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with FAM21C (PubMed:25355947).1 Publication

GO - Biological processi

  • Golgi to plasma membrane transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 93
Gene namesi
Name:CCDC93
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25611. CCDC93.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596460.

Polymorphism and mutation databases

BioMutaiCCDC93.
DMDMi97046413.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Coiled-coil domain-containing protein 93PRO_0000234604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei298 – 2981PhosphoserineCombined sources
Modified residuei301 – 3011PhosphoserineCombined sources
Modified residuei305 – 3051PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ567U6.
MaxQBiQ567U6.
PaxDbiQ567U6.
PeptideAtlasiQ567U6.
PRIDEiQ567U6.

PTM databases

iPTMnetiQ567U6.
PhosphoSiteiQ567U6.

Expressioni

Gene expression databases

BgeeiENSG00000125633.
CleanExiHS_CCDC93.
ExpressionAtlasiQ567U6. baseline and differential.
GenevisibleiQ567U6. HS.

Organism-specific databases

HPAiHPA054183.

Interactioni

Subunit structurei

Interacts with COMMD1, COMMD2 COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10, WASH1. Interacts directly with FAM21C. Interacts with CCDC93 and C16orf62; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22, CCDC93 and C16orf62; in the complex interacts directly with CCDC22 (PubMed:25355947).1 Publication1 Publication

Protein-protein interaction databases

BioGridi120013. 40 interactions.
IntActiQ567U6. 28 interactions.
STRINGi9606.ENSP00000365477.

Structurei

3D structure databases

ProteinModelPortaliQ567U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 430430Sufficient for interaction with CCDC221 PublicationAdd
BLAST
Regioni448 – 631184Sufficient for interaction with FAM21C1 PublicationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili231 – 428198Sequence analysisAdd
BLAST
Coiled coili560 – 60142Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC93 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2701. Eukaryota.
ENOG410XRRE. LUCA.
GeneTreeiENSGT00390000011294.
HOVERGENiHBG054413.
InParanoidiQ567U6.
OMAiHQIQGMD.
OrthoDBiEOG091G0DGN.
PhylomeDBiQ567U6.
TreeFamiTF323318.

Family and domain databases

InterProiIPR019159. DUF2037.
[Graphical view]
PfamiPF09762. KOG2701. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q567U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPRGPEGQ GLPEVETRED EEQNVKLTEI LELLVAAGYF RARIKGLSPF
60 70 80 90 100
DKVVGGMTWC ITTCNFDVDV DLLFQENSTI GQKIALSEKI VSVLPRMKCP
110 120 130 140 150
HQLEPHQIQG MDFIHIFPVV QWLVKRAIET KEEMGDYIRS YSVSQFQKTY
160 170 180 190 200
SLPEDDDFIK RKEKAIKTVV DLSEVYKPRR KYKRHQGAEE LLDEESRIHA
210 220 230 240 250
TLLEYGRRYG FSRQSKMEKA EDKKTALPAG LSATEKADAH EEDELRAAEE
260 270 280 290 300
QRIQSLMTKM TAMANEESRL TASSVGQIVG LCSAEIKQIV SEYAEKQSEL
310 320 330 340 350
SAEESPEKLG TSQLHRRKVI SLNKQIAQKT KHLEELRASH TSLQARYNEA
360 370 380 390 400
KKTLTELKTY SEKLDKEQAA LEKIESKADP SILQNLRALV AMNENLKSQE
410 420 430 440 450
QEFKAHCREE MTRLQQEIEN LKAERAPRGD EKTLSSGEPP GTLTSAMTHD
460 470 480 490 500
EDLDRRYNME KEKLYKIRLL QARRNREIAI LHRKIDEVPS RAELIQYQKR
510 520 530 540 550
FIELYRQISA VHKETKQFFT LYNTLDDKKV YLEKEISLLN SIHENFSQAM
560 570 580 590 600
ASPAARDQFL RQMEQIVEGI KQSRMKMEKK KQENKMRRDQ LNDQYLELLE
610 620 630
KQRLYFKTVK EFKEEGRKNE MLLSKVKAKA S
Length:631
Mass (Da):73,198
Last modified:May 16, 2006 - v2
Checksum:i4E8A2C350D97002B
GO

Sequence cautioni

The sequence BAB15188 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE06075 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391Y → H in AAH28609 (PubMed:15489334).Curated
Sequence conflicti504 – 5041L → P in BAA91945 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791R → C.2 Publications
Corresponds to variant rs33975708 [ dbSNP | Ensembl ].
VAR_054108
Natural varianti213 – 2131R → C.1 Publication
Corresponds to variant rs34095554 [ dbSNP | Ensembl ].
VAR_054109
Natural varianti228 – 2281P → L.
Corresponds to variant rs17512204 [ dbSNP | Ensembl ].
VAR_054110
Natural varianti315 – 3151H → R in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035499
Natural varianti465 – 4651Y → H.
Corresponds to variant rs17047557 [ dbSNP | Ensembl ].
VAR_054111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209993 mRNA. Translation: BAE06075.1. Different initiation.
AK001858 mRNA. Translation: BAA91945.1.
AK025611 mRNA. Translation: BAB15188.1. Different initiation.
AK290722 mRNA. Translation: BAF83411.1.
AC009303 Genomic DNA. Translation: AAX93279.1. Sequence problems.
AC009404 Genomic DNA. No translation available.
CH471103 Genomic DNA. Translation: EAW95197.1.
BC028609 mRNA. Translation: AAH28609.2.
BC093018 mRNA. Translation: AAH93018.1.
CCDSiCCDS2121.2.
RefSeqiNP_061917.3. NM_019044.4.
UniGeneiHs.107845.

Genome annotation databases

EnsembliENST00000376300; ENSP00000365477; ENSG00000125633.
GeneIDi54520.
KEGGihsa:54520.
UCSCiuc002tlj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209993 mRNA. Translation: BAE06075.1. Different initiation.
AK001858 mRNA. Translation: BAA91945.1.
AK025611 mRNA. Translation: BAB15188.1. Different initiation.
AK290722 mRNA. Translation: BAF83411.1.
AC009303 Genomic DNA. Translation: AAX93279.1. Sequence problems.
AC009404 Genomic DNA. No translation available.
CH471103 Genomic DNA. Translation: EAW95197.1.
BC028609 mRNA. Translation: AAH28609.2.
BC093018 mRNA. Translation: AAH93018.1.
CCDSiCCDS2121.2.
RefSeqiNP_061917.3. NM_019044.4.
UniGeneiHs.107845.

3D structure databases

ProteinModelPortaliQ567U6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120013. 40 interactions.
IntActiQ567U6. 28 interactions.
STRINGi9606.ENSP00000365477.

PTM databases

iPTMnetiQ567U6.
PhosphoSiteiQ567U6.

Polymorphism and mutation databases

BioMutaiCCDC93.
DMDMi97046413.

Proteomic databases

EPDiQ567U6.
MaxQBiQ567U6.
PaxDbiQ567U6.
PeptideAtlasiQ567U6.
PRIDEiQ567U6.

Protocols and materials databases

DNASUi54520.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376300; ENSP00000365477; ENSG00000125633.
GeneIDi54520.
KEGGihsa:54520.
UCSCiuc002tlj.4. human.

Organism-specific databases

CTDi54520.
GeneCardsiCCDC93.
H-InvDBHIX0002402.
HGNCiHGNC:25611. CCDC93.
HPAiHPA054183.
neXtProtiNX_Q567U6.
PharmGKBiPA144596460.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2701. Eukaryota.
ENOG410XRRE. LUCA.
GeneTreeiENSGT00390000011294.
HOVERGENiHBG054413.
InParanoidiQ567U6.
OMAiHQIQGMD.
OrthoDBiEOG091G0DGN.
PhylomeDBiQ567U6.
TreeFamiTF323318.

Miscellaneous databases

ChiTaRSiCCDC93. human.
GeneWikiiCCDC93.
GenomeRNAii54520.
PROiQ567U6.

Gene expression databases

BgeeiENSG00000125633.
CleanExiHS_CCDC93.
ExpressionAtlasiQ567U6. baseline and differential.
GenevisibleiQ567U6. HS.

Family and domain databases

InterProiIPR019159. DUF2037.
[Graphical view]
PfamiPF09762. KOG2701. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCD93_HUMAN
AccessioniPrimary (citable) accession number: Q567U6
Secondary accession number(s): A8K3V7
, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.