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Protein

Type 4 prepilin-like proteins leader peptide-processing enzyme

Gene

xpsO

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue.By similarity

Catalytic activityi

Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Methyltransferase, Multifunctional enzyme, Protease, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciXCAM190485:G1FZM-3099-MONOMER

Protein family/group databases

MEROPSiA24.001

Names & Taxonomyi

Protein namesi
Recommended name:
Type 4 prepilin-like proteins leader peptide-processing enzyme
Including the following 2 domains:
Leader peptidase (EC:3.4.23.43)
Alternative name(s):
Prepilin peptidase
N-methyltransferase (EC:2.1.1.-)
Gene namesi
Name:xpsO
Synonyms:pilD
Ordered Locus Names:XCC3101
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001926311 – 287Type 4 prepilin-like proteins leader peptide-processing enzymeAdd BLAST287

Proteomic databases

PRIDEiQ56763

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC3101

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EHH Bacteria
COG1989 LUCA
HOGENOMiHOG000248584
KOiK02654
OMAiVFWLFKL

Family and domain databases

InterProiView protein in InterPro
IPR010627 Pept_A24A_N
IPR014032 Peptidase_A24A_bac
IPR000045 Prepilin_IV_endopep_pep
PfamiView protein in Pfam
PF06750 DiS_P_DiS, 1 hit
PF01478 Peptidase_A24, 1 hit
PRINTSiPR00864 PREPILNPTASE

Sequencei

Sequence statusi: Complete.

Q56763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLDQHPGL GFPAAAGLGL LIGSFLNVVI LRLPKRMEWQ WRRDAREILE
60 70 80 90 100
LPDIYEPPPP GIVVEPSHDP VTGDKLKWWE NIPLFSWLML RGKSRYSGKP
110 120 130 140 150
ISIQYPLVEL LTSILCVASV WRFGFGWQGF GAIVLSCFLV AMSGIDLRHK
160 170 180 190 200
LLPDQLTLPL MWLGLVGSMD NLYMPAKPAL LGAAVGYVSL WTVWWLFKQL
210 220 230 240 250
TGKEGMGHGD FKLLAALGAW CGLKGILPII LISSLVGAVL GSIWLFAKGR
260 270 280
DRATPIPFGP YLAIAGWVVF FWGNDLVDGY LRFAGLR
Length:287
Mass (Da):31,843
Last modified:November 1, 1996 - v1
Checksum:iA58DD1A514F9ECC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12432 Genomic DNA Translation: AAC43571.1
AE008922 Genomic DNA Translation: AAM42372.1
PIRiS70810
RefSeqiNP_638448.1, NC_003902.1
WP_011038216.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM42372; AAM42372; XCC3101
GeneIDi998351
KEGGixcc:XCC3101
PATRICifig|190485.4.peg.3313

Similar proteinsi

Entry informationi

Entry nameiLEP4_XANCP
AccessioniPrimary (citable) accession number: Q56763
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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