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Protein

Type 4 prepilin-like proteins leader peptide-processing enzyme

Gene

vvpD

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue.By similarity

Catalytic activityi

Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Methyltransferase, Protease, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-1430-MONOMER.

Protein family/group databases

MEROPSiA24.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Type 4 prepilin-like proteins leader peptide-processing enzyme
Including the following 2 domains:
Leader peptidase (EC:3.4.23.43)
Alternative name(s):
Prepilin peptidase
N-methyltransferase (EC:2.1.1.-)
Gene namesi
Name:vvpD
Ordered Locus Names:VV1_1623
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence analysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence analysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence analysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST
Transmembranei254 – 27421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Type 4 prepilin-like proteins leader peptide-processing enzymePRO_0000192630Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_1623.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EHH. Bacteria.
COG1989. LUCA.
HOGENOMiHOG000248584.
KOiK02654.
OMAiVFWLFKL.
OrthoDBiPOG091H01KW.

Family and domain databases

InterProiIPR010627. Pept_A24A_N.
IPR014032. Peptidase_A24A_bac.
IPR000045. Prepilin_IV_endopep_pep.
[Graphical view]
PfamiPF06750. DiS_P_DiS. 1 hit.
PF01478. Peptidase_A24. 1 hit.
[Graphical view]
PRINTSiPR00864. PREPILNPTASE.

Sequencei

Sequence statusi: Complete.

Q56740-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDALQYYPWL YIGLASLFGL LVGSFLNVVI YRLPKIMELE WRQECAESFP
60 70 80 90 100
EYNITPPTET LTLSTPRSSC PSCHTPIRVR DNIPVFSWLA LRGKCHHCQT
110 120 130 140 150
KISARYPFVE ALSAFLCGLV AWKFGYAPIT VALIGFTLVL IAATFIDLDT
160 170 180 190 200
MLLPDQLTLP LTWTGIALAL LEISPVSLQD SVFGAMAGYL CLWSVYHLFR
210 220 230 240 250
LLTGKEGMGY GDFKLLAALG AWLGWQYLPM IILLSSVVGL IFGLIQLRLQ
260 270 280
KQGIEMAFPF GPYLAIAGWV ALMWGDSLMS WYLNYLIGA
Length:289
Mass (Da):32,295
Last modified:November 1, 1996 - v1
Checksum:i0B3479B870F9C6B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48808 Genomic DNA. Translation: AAA91206.1.
AF070934 Genomic DNA. Translation: AAC23601.1.
AE016795 Genomic DNA. Translation: AAO10042.1.
RefSeqiWP_011079548.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO10042; AAO10042; VV1_1623.
KEGGivvu:VV1_1623.
PATRICi20160033. VBIVibVul94426_1502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48808 Genomic DNA. Translation: AAA91206.1.
AF070934 Genomic DNA. Translation: AAC23601.1.
AE016795 Genomic DNA. Translation: AAO10042.1.
RefSeqiWP_011079548.1. NC_004459.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216895.VV1_1623.

Protein family/group databases

MEROPSiA24.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO10042; AAO10042; VV1_1623.
KEGGivvu:VV1_1623.
PATRICi20160033. VBIVibVul94426_1502.

Phylogenomic databases

eggNOGiENOG4105EHH. Bacteria.
COG1989. LUCA.
HOGENOMiHOG000248584.
KOiK02654.
OMAiVFWLFKL.
OrthoDBiPOG091H01KW.

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-1430-MONOMER.

Family and domain databases

InterProiIPR010627. Pept_A24A_N.
IPR014032. Peptidase_A24A_bac.
IPR000045. Prepilin_IV_endopep_pep.
[Graphical view]
PfamiPF06750. DiS_P_DiS. 1 hit.
PF01478. Peptidase_A24. 1 hit.
[Graphical view]
PRINTSiPR00864. PREPILNPTASE.
ProtoNetiSearch...

Entry informationi

Entry nameiLEP4_VIBVU
AccessioniPrimary (citable) accession number: Q56740
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.