ID   DHAS_SHEVI              Reviewed;         338 AA.
AC   Q56734;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=Aspartate-semialdehyde dehydrogenase;
DE            Short=ASA dehydrogenase;
DE            Short=ASADH;
DE            EC=1.2.1.11;
GN   Name=asd;
OS   Shewanella violacea.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=60217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSS12;
RX   MEDLINE=97306055; PubMed=9163523;
RA   Kato C., Smorawinska M., Li L., Horikoshi K.;
RT   "Comparison of the gene expression of aspartate beta-D-semialdehyde
RT   dehydrogenase at elevated hydrostatic pressure in deep-sea bacteria.";
RL   J. Biochem. 121:717-723(1997).
CC   -!- CATALYTIC ACTIVITY: L-aspartate 4-semialdehyde + phosphate +
CC       NADP(+) = L-4-aspartyl phosphate + NADPH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; tetrahydrodipicolinate from L-aspartate: step 2/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 2/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 2/5.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the aspartate-semialdehyde dehydrogenase
CC       family.
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DR   EMBL; D49540; BAA08490.1; -; Genomic_DNA.
DR   PIR; JC5436; JC5436.
DR   HSSP; P00353; 1BRM.
DR   BRENDA; 1.2.1.11; 292658.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004073; F:aspartate-semialdehyde dehydrogenase activity; IEA:EC.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:InterPro.
DR   InterPro; IPR000319; Asp-semialdehyde_DH_CS.
DR   InterPro; IPR012080; Asp_semialdehyde_DH.
DR   InterPro; IPR005986; Asp_semialdehyde_DH_bac.
DR   InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR   InterPro; IPR012280; Semialdhyde_DH_C.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   Pfam; PF02774; Semialdhyde_dhC; 1.
DR   PIRSF; PIRSF000148; ASA_dh; 1.
DR   TIGRFAMs; TIGR01296; asd_B; 1.
DR   PROSITE; PS01103; ASD; FALSE_NEG.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Diaminopimelate biosynthesis;
KW   Lysine biosynthesis; NADP; Oxidoreductase.
FT   CHAIN         1    338       Aspartate-semialdehyde dehydrogenase.
FT                                /FTId=PRO_0000141390.
FT   ACT_SITE    132    132       Acyl-thioester intermediate (By
FT                                similarity).
SQ   SEQUENCE   338 AA;  37061 MW;  8D0DC1F46EAF30AC CRC64;
     MSQEFNVVVL GASGAVGQTM IEILEERNFP VAKLFPLASS RSAGGTVSFN GKQVEILDVD
     DFDWSQAQIG FFSAGGDVSE KWAPIAAENG CVVIDNTSQF RYDNDVPLVI PEVNPEAIAD
     FRNRNIIANP NCSTIQMLVA LKPIYDAFGI SRINVATYQS VSGSGKEAIT ELAGQCSKLL
     HGLPAESKVY PKQIAFNVLP QIDKFMENGY TKEEMKMVWE TQKIFGDDNI VVNPTAVRVP
     VFYGHSEAIH LETIQPAEAE DVKAVLREAP GIELFESNEE YPTAVTESAG TDPVYVGRVR
     KDISHSHGIN LWVVSDNIRK GAALNSVQIA EVLIRDYY
//