Q56712 (FLAC_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Polar flagellin C

Gene names

Name:	flaC
Ordered Locus Names:	VP0788

Organism

Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) [Complete proteome] [HAMAP]

Taxonomic identifier

223926 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio harveyi group › Vibrio parahaemolyticus

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaC is not essential for polar flagellar synthesis and swimming motility. Homopolymer of FlaC is not able to form a functional filament.
Subunit structure	Heteropolymer of multiple flagellin subunits including FlaA, FlaB/D, FlaC, FlaE and FlaF. Homopolymer of FlaC is not able to form a functional filament.
Subcellular location	Secreted. Bacterial flagellum.
Miscellaneous	V.parahaemolyticus possesses two flagellar systems: a single polar flagellum propels the bacterium in liquid (swimming), while multiple lateral (peritrichous) flagella move the bacterium over surfaces (swarming). The polar flagellum is synthesized constitutively but lateral flagella are produced only under conditions in which the polar flagellum is not functional.
Sequence similarities	Belongs to the bacterial flagellin family.

Ontologies

Keywords
Cellular component	Bacterial flagellum Secreted
Domain	Coiled coil
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ciliary or flagellar motility Inferred from electronic annotation. Source: InterPro flagellum organization Inferred from electronic annotation. Source: InterPro
Cellular_component	bacterial-type flagellum filament Inferred from electronic annotation. Source: InterPro extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Polar flagellin C		PRO_0000182655
Regions
	Coiled coil	317 – 347	31	Potential
Experimental info
	Sequence conflict	277	1	E → Q in AAD10271. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q56712 [UniParc]. Last modified April 4, 2003. Version 2. Checksum: C239846EC9A8558A	FASTA	384	40,812
	10 20 30 40 50 60 MAVTVSTNVS AMTAQRYLNK ATNELNTSME RLSSGHKINS AKDDAAGLQI SNRLTAQSRG 70 80 90 100 110 120 LDVAMRNAND GISIAQTAEG AMNEATSVMQ RMRDLAIQSS NGTNSPAERQ AINEESMALV 130 140 150 160 170 180 DELNRIAETT SFGGRRLLNG SFGEAAFQIG ASSGEAMIMG LTSIRADDTR MGGVTFFSEV 190 200 210 220 230 240 GKGKDWGVDP TKADLKITLP GMGEDEDGNV DDLEININAK AGDDIEELAT YINGQSDMIN 250 260 270 280 290 300 ASVSEDGKLQ IFVAHPNVQG DISISGGLAS ELGLSDEPVR TSVQDIDMTT VQGSQNAISV 310 320 330 340 350 360 LDSALKYVDS QRADLGAKQN RLSHSINNLA NIQENVDASN SRIKDTDFAK ETTQMTKAQI 370 380 LQQAGTSILA QAKQLPNSAM SLLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic and molecular characterization of the polar flagellum of Vibrio parahaemolyticus." McCarter L.L. J. Bacteriol. 177:1595-1609(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BB22.
[2]	"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae." Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T. Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RIMD 2210633.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U12817 Genomic DNA. Translation: AAD10271.1. BA000031 Genomic DNA. Translation: BAC59051.1.
RefSeq	NP_797167.1. NC_004603.1.
3D structure databases
ProteinModelPortal	Q56712.
SMR	Q56712. Positions 345-383.
ModBase	Search...
Protein-protein interaction databases
STRING	223926.VP0788.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC59051; BAC59051; BAC59051.
GeneID	1188285.
KEGG	vpa:VP0788.
PATRIC	20139814. VBIVibPar50997_0752.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1344.
HOGENOM	HOG000255144.
KO	K02406.
OMA	GEAMIMG.
ProtClustDB	PRK08869.
Family and domain databases
InterPro	IPR001492. Flagellin. IPR001029. Flagellin_D0/D1. IPR010810. Flagellin_hook_IN_motif. [Graphical view]
Pfam	PF00700. Flagellin_C. 1 hit. PF07196. Flagellin_IN. 1 hit. PF00669. Flagellin_N. 1 hit. [Graphical view]
PRINTS	PR00207. FLAGELLIN.
ProtoNet	Search...

Entry information

Entry name

FLAC_VIBPA

Accession

Primary (citable) accession number: Q56712

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	April 4, 2003
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program