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Protein

Protein mago nashi homolog

Gene

magoh

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, mRNA transport, Nonsense-mediated mRNA decay, Translation regulation, Transport

Enzyme and pathway databases

ReactomeiR-DRE-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DRE-72163 mRNA Splicing - Major Pathway
R-DRE-72187 mRNA 3'-end processing
R-DRE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Protein mago nashi homolog
Gene namesi
Name:magoh
ORF Names:ch211-216k22.5, zgc:112220
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-041216-1 magoh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003785841 – 147Protein mago nashi homologAdd BLAST147

Proteomic databases

PaxDbiQ566Y8
PRIDEiQ566Y8

Expressioni

Gene expression databases

BgeeiENSDARG00000038635

Interactioni

Subunit structurei

Part of the EJC core complex that contains casc3, eif4a3, magoh and rbm8a.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000056404

Structurei

3D structure databases

ProteinModelPortaliQ566Y8
SMRiQ566Y8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mago nashi family.Curated

Phylogenomic databases

eggNOGiKOG3392 Eukaryota
ENOG4111FJ7 LUCA
GeneTreeiENSGT00390000003156
HOGENOMiHOG000207428
InParanoidiQ566Y8
KOiK12877
OMAiEFDFRVV
OrthoDBiEOG091G0UKA
PhylomeDBiQ566Y8
TreeFamiTF300128

Family and domain databases

CDDicd11295 Mago_nashi, 1 hit
Gene3Di3.30.1560.10, 1 hit
InterProiView protein in InterPro
IPR004023 Mago_nashi
IPR036605 Mago_nashi_sf
PANTHERiPTHR12638 PTHR12638, 1 hit
PfamiView protein in Pfam
PF02792 Mago_nashi, 1 hit
SUPFAMiSSF89817 SSF89817, 1 hit

Sequencei

Sequence statusi: Complete.

Q566Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSDFYLRY YVGHKGKFGH EFLEFEFRPD GKLRYANNSN YKNDVMIRKE
60 70 80 90 100
AYVHKSVMEE LKRIIDDSEI TKEDDALWPP PDRVGRQELE IVIGDEHISF
110 120 130 140
TTSKIGSLID VNQSKDPEGL RVFYYLVQDL KCLVFSLIGL HFKIKPI
Length:147
Mass (Da):17,223
Last modified:May 10, 2005 - v1
Checksum:i0AF29A474A15740E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927144 Genomic DNA Translation: CAQ13313.1
BC093273 mRNA Translation: AAH93273.1
RefSeqiNP_001017700.1, NM_001017700.1
UniGeneiDr.43183

Genome annotation databases

EnsembliENSDART00000056405; ENSDARP00000056404; ENSDARG00000038635
GeneIDi100005893
KEGGidre:100005893

Similar proteinsi

Entry informationi

Entry nameiMGN_DANRE
AccessioniPrimary (citable) accession number: Q566Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health