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Protein

Protein mago nashi homolog

Gene

magoh

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing, mRNA transport, Nonsense-mediated mRNA decay, Translation regulation, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-DRE-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-DRE-72163. mRNA Splicing - Major Pathway.
R-DRE-72187. mRNA 3'-end processing.
R-DRE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein mago nashi homolog
Gene namesi
Name:magoh
ORF Names:ch211-216k22.5, zgc:112220
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-041216-1. magoh.

Subcellular locationi

  • Nucleus By similarity
  • Nucleus speckle By similarity
  • Cytoplasm By similarity

  • Note: Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003785841 – 147Protein mago nashi homologAdd BLAST147

Proteomic databases

PaxDbiQ566Y8.
PRIDEiQ566Y8.

Expressioni

Gene expression databases

BgeeiENSDARG00000038635.

Interactioni

Subunit structurei

Part of the EJC core complex that contains casc3, eif4a3, magoh and rbm8a.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000056404.

Structurei

3D structure databases

ProteinModelPortaliQ566Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mago nashi family.Curated

Phylogenomic databases

eggNOGiKOG3392. Eukaryota.
ENOG4111FJ7. LUCA.
GeneTreeiENSGT00390000003156.
HOGENOMiHOG000207428.
InParanoidiQ566Y8.
KOiK12877.
OMAiKEDDTNW.
OrthoDBiEOG091G0UKA.
PhylomeDBiQ566Y8.
TreeFamiTF300128.

Family and domain databases

CDDicd11295. Mago_nashi. 1 hit.
Gene3Di3.30.1560.10. 1 hit.
InterProiIPR004023. Mago_nashi.
[Graphical view]
PANTHERiPTHR12638. PTHR12638. 1 hit.
PfamiPF02792. Mago_nashi. 1 hit.
[Graphical view]
SUPFAMiSSF89817. SSF89817. 1 hit.

Sequencei

Sequence statusi: Complete.

Q566Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSDFYLRY YVGHKGKFGH EFLEFEFRPD GKLRYANNSN YKNDVMIRKE
60 70 80 90 100
AYVHKSVMEE LKRIIDDSEI TKEDDALWPP PDRVGRQELE IVIGDEHISF
110 120 130 140
TTSKIGSLID VNQSKDPEGL RVFYYLVQDL KCLVFSLIGL HFKIKPI
Length:147
Mass (Da):17,223
Last modified:May 10, 2005 - v1
Checksum:i0AF29A474A15740E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927144 Genomic DNA. Translation: CAQ13313.1.
BC093273 mRNA. Translation: AAH93273.1.
RefSeqiNP_001017700.1. NM_001017700.1.
UniGeneiDr.43183.

Genome annotation databases

EnsembliENSDART00000056405; ENSDARP00000056404; ENSDARG00000038635.
GeneIDi100005893.
KEGGidre:100005893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927144 Genomic DNA. Translation: CAQ13313.1.
BC093273 mRNA. Translation: AAH93273.1.
RefSeqiNP_001017700.1. NM_001017700.1.
UniGeneiDr.43183.

3D structure databases

ProteinModelPortaliQ566Y8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000056404.

Proteomic databases

PaxDbiQ566Y8.
PRIDEiQ566Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000056405; ENSDARP00000056404; ENSDARG00000038635.
GeneIDi100005893.
KEGGidre:100005893.

Organism-specific databases

CTDi4116.
ZFINiZDB-GENE-041216-1. magoh.

Phylogenomic databases

eggNOGiKOG3392. Eukaryota.
ENOG4111FJ7. LUCA.
GeneTreeiENSGT00390000003156.
HOGENOMiHOG000207428.
InParanoidiQ566Y8.
KOiK12877.
OMAiKEDDTNW.
OrthoDBiEOG091G0UKA.
PhylomeDBiQ566Y8.
TreeFamiTF300128.

Enzyme and pathway databases

ReactomeiR-DRE-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-DRE-72163. mRNA Splicing - Major Pathway.
R-DRE-72187. mRNA 3'-end processing.
R-DRE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiQ566Y8.

Gene expression databases

BgeeiENSDARG00000038635.

Family and domain databases

CDDicd11295. Mago_nashi. 1 hit.
Gene3Di3.30.1560.10. 1 hit.
InterProiIPR004023. Mago_nashi.
[Graphical view]
PANTHERiPTHR12638. PTHR12638. 1 hit.
PfamiPF02792. Mago_nashi. 1 hit.
[Graphical view]
SUPFAMiSSF89817. SSF89817. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMGN_DANRE
AccessioniPrimary (citable) accession number: Q566Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: May 10, 2005
Last modified: October 5, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.