Q566R7 (DS22B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity protein phosphatase 22-B
EC=3.1.3.16
EC=3.1.3.48

Gene names

Name:	dusp22b
Synonyms:	dusp22
ORF Names:	si:ch73-170d1.1, zgc:112536

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC positive regulation of JNK cascade Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of cell proliferation Inferred from Biological aspect of Ancestor. Source: RefGenome transforming growth factor beta receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 183	183	Dual specificity protein phosphatase 22-B		PRO_0000244753
Regions
	Domain	65 – 133	69	Tyrosine-protein phosphatase
Sites
	Active site	88	1	Phosphocysteine intermediate By similarity
Experimental info
	Sequence conflict	119	1	K → R in AAH93370. Ref.2
	Sequence conflict	131	1	F → S in AAH93370. Ref.2
	Sequence conflict	170	1	T → A in AAH93370. Ref.2
	Sequence conflict	179	1	E → D in AAH93370. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q566R7 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 0E5E8EB5442978AF	FASTA	183	20,631
	10 20 30 40 50 60 MGNGINKVLP DLYLGNFKDA RDREQLARNN ITHILSIHDT AAPILQEMTY LCIAAADSPT 70 80 90 100 110 120 QNLIQHFRQS IAFIHQSRLK GEGCLVHCLA GVSRSVTLVV AYIMTVTTLG WQEALAAVKI 130 140 150 160 170 180 ARPCASPNTG FQNQLQEFQT GELQQFREWL KEEYKENPFN DEEDIRNLLT KASTEEDAEL QNN

References

[1]	The Danio rerio sequencing project at the Sanger Institute Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL935300 Genomic DNA. No translation available. CT962510 Genomic DNA. No translation available. BC093370 mRNA. Translation: AAH93370.1.
IPI	IPI00570215.
RefSeq	NP_001017742.2. NM_001017742.2.
UniGene	Dr.82240.
3D structure databases
ProteinModelPortal	Q566R7.
SMR	Q566R7. Positions 1-154.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000058289; ENSDARP00000058288; ENSDARG00000039850.
GeneID	100002272.
KEGG	dre:100002272.
Organism-specific databases
CTD	100002272.
ZFIN	ZDB-GENE-050417-257. dusp22b.
Phylogenomic databases
eggNOG	COG2453.
GeneTree	ENSGT00680000099678.
HOGENOM	HOG000007880.
HOVERGEN	HBG054344.
InParanoid	Q566R7.
KO	K04459.
OMA	WLREEYG.
OrthoDB	EOG4RFKT3.
Gene expression databases
Bgee	Q566R7.
Family and domain databases
InterPro	IPR020417. Atypical_DUSP. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20785381.

Entry information

Entry name

DS22B_DANRE

Accession

Primary (citable) accession number: Q566R7
Secondary accession number(s): A8B8L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	February 26, 2008
Last modified:	March 6, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program