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Protein

AarF domain-containing protein kinase 4

Gene

Adck4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in CoQ10 (COQ10A and/or COQ10B) biosynthesis, which is required for podocyte migration.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AarF domain-containing protein kinase 4 (EC:2.7.11.-)
Gene namesi
Name:Adck4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1924139. Adck4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei93 – 10917HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533AarF domain-containing protein kinase 4PRO_0000271798Add
BLAST

Proteomic databases

EPDiQ566J8.
MaxQBiQ566J8.
PaxDbiQ566J8.
PRIDEiQ566J8.

PTM databases

PhosphoSiteiQ566J8.

Expressioni

Gene expression databases

BgeeiQ566J8.
CleanExiMM_ADCK4.

Interactioni

Subunit structurei

Homodimer; homodimerizes via its transmembrane region. Interacts with COQ6 and COQ7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003860.

Structurei

3D structure databases

ProteinModelPortaliQ566J8.
SMRiQ566J8. Positions 138-520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 424233Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1234. Eukaryota.
COG0661. LUCA.
HOGENOMiHOG000201140.
HOVERGENiHBG061318.
InParanoidiQ566J8.
OrthoDBiEOG7X9G6H.
PhylomeDBiQ566J8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequencei

Sequence statusi: Complete.

Q566J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLELGAMLR RTCGPLGRAV RLPCGGALGP RPHWWGPCRS CLAQSVHQDQ
60 70 80 90 100
PGRGLSEDDI RRAREARLRK APRPQLSDRS RERKVPASRI SRLASFGGLA
110 120 130 140 150
VGLGLGALAE VTKKSLPGGS LQHEGVSGLG SSPFLSEANA ERIVQTLCTV
160 170 180 190 200
RGAALKIGQM LSIQDNSFIS PQLQRIFERV RQSADFMPRW QMMRVLEEEL
210 220 230 240 250
GKDWQDKVAS LEEVPFAAAS IGQVHQGLLK DGTEVAVKIQ YPGVAQSIQS
260 270 280 290 300
DVENLLALLK MSVGLPEGLF AEQSLQTLQQ ELAWECDYRR EAACAQTFRK
310 320 330 340 350
LLADDPFFRV PAVVQELCTT RVLGMELAGG IPLDQCQGLS QDIRNQICFQ
360 370 380 390 400
LLRLCLRELF EFRFMQTDPN WANFLYDASS HQVTLLDFGA SRAFGTEFTD
410 420 430 440 450
HYIEVVKAAA DGDRDRVLQK SQDLKFLTGF ETKAFSDAHV EAVMILGEPF
460 470 480 490 500
AASGPYDFGA GETARRIQGL IPVLLRHRLR PPPEETYALH RKLAGAFLAC
510 520 530
ARLHAHIACR DLFQDTYHRY WASRQTLPLP AAS
Length:533
Mass (Da):59,232
Last modified:May 10, 2005 - v1
Checksum:i72B8FC097972E290
GO

Sequence cautioni

The sequence AAH13485.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti289 – 2891R → C in AAH83324 (PubMed:15489334).Curated
Sequence conflicti300 – 3045KLLAD → SAFSS in AAH83324 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013485 mRNA. Translation: AAH13485.1. Different initiation.
BC083324 mRNA. Translation: AAH83324.1.
BC093498 mRNA. Translation: AAH93498.1.
CCDSiCCDS39847.1.
UniGeneiMm.124728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013485 mRNA. Translation: AAH13485.1. Different initiation.
BC083324 mRNA. Translation: AAH83324.1.
BC093498 mRNA. Translation: AAH93498.1.
CCDSiCCDS39847.1.
UniGeneiMm.124728.

3D structure databases

ProteinModelPortaliQ566J8.
SMRiQ566J8. Positions 138-520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003860.

PTM databases

PhosphoSiteiQ566J8.

Proteomic databases

EPDiQ566J8.
MaxQBiQ566J8.
PaxDbiQ566J8.
PRIDEiQ566J8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1924139. Adck4.

Phylogenomic databases

eggNOGiKOG1234. Eukaryota.
COG0661. LUCA.
HOGENOMiHOG000201140.
HOVERGENiHBG061318.
InParanoidiQ566J8.
OrthoDBiEOG7X9G6H.
PhylomeDBiQ566J8.

Miscellaneous databases

PROiQ566J8.
SOURCEiSearch...

Gene expression databases

BgeeiQ566J8.
CleanExiMM_ADCK4.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain, Kidney and Mammary tumor.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney and Spleen.

Entry informationi

Entry nameiADCK4_MOUSE
AccessioniPrimary (citable) accession number: Q566J8
Secondary accession number(s): Q5XJH7, Q91WT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 10, 2005
Last modified: March 16, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.