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Protein

CMRF35-like molecule 1

Gene

Cd300lf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei243 – 2431Phosphatase-bindingBy similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule 1
Short name:
CLM-1
Alternative name(s):
CD300 antigen-like family member F
CD_antigen: CD300f
Gene namesi
Name:Cd300lf
Synonyms:Clm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309733. Cd300lf.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 181163ExtracellularSequence analysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence analysisAdd
BLAST
Topological domaini203 – 332130CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 332314CMRF35-like molecule 1PRO_0000247827Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 109By similarity
Disulfide bondi55 ↔ 63By similarity
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ566E6.
PRIDEiQ566E6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021424.

Interactioni

Subunit structurei

Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033887.

Structurei

3D structure databases

ProteinModelPortaliQ566E6.
SMRiQ566E6. Positions 20-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 125104Ig-like V-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi131 – 15828Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the CD300 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ4I. Eukaryota.
ENOG410YT8T. LUCA.
HOGENOMiHOG000231065.
HOVERGENiHBG050999.
InParanoidiQ566E6.
OrthoDBiEOG091G0O8X.
PhylomeDBiQ566E6.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q566E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSLLALFL FWISGCFTAQ DPVTGPEEVS GYEQGSLTVW CRYGSWWKDY
60 70 80 90 100
SKYWCRGPKR SSCEIRVETD ASERLVKENH VSIRDDQTNF TFTVTMEDLR
110 120 130 140 150
MSDAGIYWCG ITKAGYDHMF KVHVSINPVP TTPTTTSTTT IFTVTTTVKE
160 170 180 190 200
TSTLSTQTSH YSDNRYDSGG VGDGNGFLDL SVLLPVISAA LLLLLLVVSL
210 220 230 240 250
IAWRMVRRQK KAAGPPSGQA DSVTHILCPP KPHVQPLEDD LCYANLSLQQ
260 270 280 290 300
PRTSPLKKGS SMSSSGKDHQ EEVEYVTMAP FPREEISYAA LSLASLGQEP
310 320 330
TYSNTACLVT HGPRTNLGEE TTEYSSIRRP MP
Length:332
Mass (Da):36,823
Last modified:May 10, 2005 - v1
Checksum:i7249D9D7EF5D67C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093593 mRNA. Translation: AAH93593.1.
RefSeqiNP_001020282.1. NM_001025111.1.
UniGeneiRn.130740.

Genome annotation databases

GeneIDi287818.
KEGGirno:287818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093593 mRNA. Translation: AAH93593.1.
RefSeqiNP_001020282.1. NM_001025111.1.
UniGeneiRn.130740.

3D structure databases

ProteinModelPortaliQ566E6.
SMRiQ566E6. Positions 20-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033887.

Proteomic databases

PaxDbiQ566E6.
PRIDEiQ566E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi287818.
KEGGirno:287818.

Organism-specific databases

CTDi146722.
RGDi1309733. Cd300lf.

Phylogenomic databases

eggNOGiENOG410IZ4I. Eukaryota.
ENOG410YT8T. LUCA.
HOGENOMiHOG000231065.
HOVERGENiHBG050999.
InParanoidiQ566E6.
OrthoDBiEOG091G0O8X.
PhylomeDBiQ566E6.
TreeFamiTF334441.

Miscellaneous databases

PROiQ566E6.

Gene expression databases

BgeeiENSRNOG00000021424.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCLM1_RAT
AccessioniPrimary (citable) accession number: Q566E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.