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Protein

KDEL motif-containing protein 2

Gene

Kdelc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL motif-containing protein 2
Gene namesi
Name:Kdelc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1562027. Kdelc2.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 508484KDEL motif-containing protein 2PRO_0000247197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ566E5.
PRIDEiQ566E5.

Expressioni

Gene expression databases

GenevestigatoriQ566E5.

Structurei

3D structure databases

ProteinModelPortaliQ566E5.
SMRiQ566E5. Positions 22-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 134110FilaminAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi505 – 5084Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the KDELC family.Curated
Contains 1 filamin repeat.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248922.
GeneTreeiENSGT00530000063132.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ566E5.
OMAiLRPWKHY.
OrthoDBiEOG7XDBG0.
PhylomeDBiQ566E5.
TreeFamiTF323280.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q566E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGVRRALLL PPLQLALLVA AGTGARVSAP RSLAWGPGLH ADAVLPVRYF
60 70 80 90 100
FLQSVDSDGR NFTSSPPGQT QFKVVVKSLS PKELVRIYVP KPLDRNDGTF
110 120 130 140 150
LVRYRMHETV HEGLKIEILY GGEHVAQSPY ILKGPVYHEY CDCPEDDPQA
160 170 180 190 200
WQKTLSCPAN EPQIEQDFIS FPSINLQQML KEVPKRFGDE RGAIVHYTIL
210 220 230 240 250
NNHIYRRSLG KYTDFKMFSD EILLSLARKV TLPDLEFYIN LGDWPLEHRK
260 270 280 290 300
VNDTPGPIPI ISWCGSLDSR DIILPTYDVT HSTLEAMRGV TNDLLSVQGN
310 320 330 340 350
TGPSWINKTE KAFFRGRDSR EERLQLVLLS KENPQLLDAG ITGYFFFQEK
360 370 380 390 400
EKELGKAKLM GFFDFFKYKY QVNVDGTVAA YRYPYLMLGD SLVLKQESPY
410 420 430 440 450
YEHFYVELRP WKHYVPIKRN LSDLLEKVKW AKENDEEAKR IAKEGQLTAR
460 470 480 490 500
DLLQPPRLYC YYYRVLQKYA ERQVSKPMIR DGMERVPQPD DSTSVRQCHR

KRPEREEL
Length:508
Mass (Da):58,701
Last modified:May 10, 2005 - v1
Checksum:iE04AB38138CC5DF9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti496 – 4961R → C in AAI00618 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093594 mRNA. Translation: AAH93594.1.
BC100617 mRNA. Translation: AAI00618.1.
RefSeqiNP_001020294.3. NM_001025123.3.
UniGeneiRn.98686.

Genome annotation databases

EnsembliENSRNOT00000009497; ENSRNOP00000009497; ENSRNOG00000007177.
GeneIDi315664.
KEGGirno:315664.
UCSCiRGD:1562027. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093594 mRNA. Translation: AAH93594.1.
BC100617 mRNA. Translation: AAI00618.1.
RefSeqiNP_001020294.3. NM_001025123.3.
UniGeneiRn.98686.

3D structure databases

ProteinModelPortaliQ566E5.
SMRiQ566E5. Positions 22-134.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Proteomic databases

PaxDbiQ566E5.
PRIDEiQ566E5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009497; ENSRNOP00000009497; ENSRNOG00000007177.
GeneIDi315664.
KEGGirno:315664.
UCSCiRGD:1562027. rat.

Organism-specific databases

CTDi143888.
RGDi1562027. Kdelc2.

Phylogenomic databases

eggNOGiNOG248922.
GeneTreeiENSGT00530000063132.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ566E5.
OMAiLRPWKHY.
OrthoDBiEOG7XDBG0.
PhylomeDBiQ566E5.
TreeFamiTF323280.

Miscellaneous databases

NextBioi669617.
PROiQ566E5.

Gene expression databases

GenevestigatoriQ566E5.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Prostate.

Entry informationi

Entry nameiKDEL2_RAT
AccessioniPrimary (citable) accession number: Q566E5
Secondary accession number(s): Q497C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 10, 2005
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.