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Protein

KDEL motif-containing protein 2

Gene

Kdelc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL motif-containing protein 2
Gene namesi
Name:Kdelc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1562027. Kdelc2.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000024719725 – 508KDEL motif-containing protein 2Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi307N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ566E5.
PRIDEiQ566E5.

PTM databases

PhosphoSitePlusiQ566E5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007177.
GenevisibleiQ566E5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009497.

Structurei

3D structure databases

ProteinModelPortaliQ566E5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 134FilaminAdd BLAST110

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi505 – 508Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the KDELC family.Curated
Contains 1 filamin repeat.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2458. Eukaryota.
ENOG410XT5U. LUCA.
GeneTreeiENSGT00530000063132.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ566E5.
OMAiFFFRDRE.
OrthoDBiEOG091G04SJ.
PhylomeDBiQ566E5.
TreeFamiTF323280.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q566E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGVRRALLL PPLQLALLVA AGTGARVSAP RSLAWGPGLH ADAVLPVRYF
60 70 80 90 100
FLQSVDSDGR NFTSSPPGQT QFKVVVKSLS PKELVRIYVP KPLDRNDGTF
110 120 130 140 150
LVRYRMHETV HEGLKIEILY GGEHVAQSPY ILKGPVYHEY CDCPEDDPQA
160 170 180 190 200
WQKTLSCPAN EPQIEQDFIS FPSINLQQML KEVPKRFGDE RGAIVHYTIL
210 220 230 240 250
NNHIYRRSLG KYTDFKMFSD EILLSLARKV TLPDLEFYIN LGDWPLEHRK
260 270 280 290 300
VNDTPGPIPI ISWCGSLDSR DIILPTYDVT HSTLEAMRGV TNDLLSVQGN
310 320 330 340 350
TGPSWINKTE KAFFRGRDSR EERLQLVLLS KENPQLLDAG ITGYFFFQEK
360 370 380 390 400
EKELGKAKLM GFFDFFKYKY QVNVDGTVAA YRYPYLMLGD SLVLKQESPY
410 420 430 440 450
YEHFYVELRP WKHYVPIKRN LSDLLEKVKW AKENDEEAKR IAKEGQLTAR
460 470 480 490 500
DLLQPPRLYC YYYRVLQKYA ERQVSKPMIR DGMERVPQPD DSTSVRQCHR

KRPEREEL
Length:508
Mass (Da):58,701
Last modified:May 10, 2005 - v1
Checksum:iE04AB38138CC5DF9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti496R → C in AAI00618 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093594 mRNA. Translation: AAH93594.1.
BC100617 mRNA. Translation: AAI00618.1.
RefSeqiNP_001020294.3. NM_001025123.3.
UniGeneiRn.98686.

Genome annotation databases

EnsembliENSRNOT00000009497; ENSRNOP00000009497; ENSRNOG00000007177.
GeneIDi315664.
KEGGirno:315664.
UCSCiRGD:1562027. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093594 mRNA. Translation: AAH93594.1.
BC100617 mRNA. Translation: AAI00618.1.
RefSeqiNP_001020294.3. NM_001025123.3.
UniGeneiRn.98686.

3D structure databases

ProteinModelPortaliQ566E5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009497.

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

PTM databases

PhosphoSitePlusiQ566E5.

Proteomic databases

PaxDbiQ566E5.
PRIDEiQ566E5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009497; ENSRNOP00000009497; ENSRNOG00000007177.
GeneIDi315664.
KEGGirno:315664.
UCSCiRGD:1562027. rat.

Organism-specific databases

CTDi143888.
RGDi1562027. Kdelc2.

Phylogenomic databases

eggNOGiKOG2458. Eukaryota.
ENOG410XT5U. LUCA.
GeneTreeiENSGT00530000063132.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ566E5.
OMAiFFFRDRE.
OrthoDBiEOG091G04SJ.
PhylomeDBiQ566E5.
TreeFamiTF323280.

Miscellaneous databases

PROiQ566E5.

Gene expression databases

BgeeiENSRNOG00000007177.
GenevisibleiQ566E5. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDEL2_RAT
AccessioniPrimary (citable) accession number: Q566E5
Secondary accession number(s): Q497C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 10, 2005
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.