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Q566E5

- KDEL2_RAT

UniProt

Q566E5 - KDEL2_RAT

Protein

KDEL motif-containing protein 2

Gene

Kdelc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    CAZyiGT90. Glycosyltransferase Family 90.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KDEL motif-containing protein 2
    Gene namesi
    Name:Kdelc2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi1562027. Kdelc2.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 508484KDEL motif-containing protein 2PRO_0000247197Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ566E5.
    PRIDEiQ566E5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ566E5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ566E5.
    SMRiQ566E5. Positions 22-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati25 – 134110FilaminAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi505 – 5084Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the KDELC family.Curated
    Contains 1 filamin repeat.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG248922.
    GeneTreeiENSGT00530000063132.
    HOGENOMiHOG000286007.
    HOVERGENiHBG081852.
    InParanoidiQ566E5.
    OMAiPVRYFYL.
    OrthoDBiEOG7XDBG0.
    PhylomeDBiQ566E5.
    TreeFamiTF323280.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR006598. LipoPS_modifying.
    [Graphical view]
    PfamiPF00630. Filamin. 1 hit.
    PF05686. Glyco_transf_90. 1 hit.
    [Graphical view]
    SMARTiSM00672. CAP10. 1 hit.
    SM00557. IG_FLMN. 1 hit.
    [Graphical view]
    SUPFAMiSSF81296. SSF81296. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q566E5-1 [UniParc]FASTAAdd to Basket

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    MLGVRRALLL PPLQLALLVA AGTGARVSAP RSLAWGPGLH ADAVLPVRYF    50
    FLQSVDSDGR NFTSSPPGQT QFKVVVKSLS PKELVRIYVP KPLDRNDGTF 100
    LVRYRMHETV HEGLKIEILY GGEHVAQSPY ILKGPVYHEY CDCPEDDPQA 150
    WQKTLSCPAN EPQIEQDFIS FPSINLQQML KEVPKRFGDE RGAIVHYTIL 200
    NNHIYRRSLG KYTDFKMFSD EILLSLARKV TLPDLEFYIN LGDWPLEHRK 250
    VNDTPGPIPI ISWCGSLDSR DIILPTYDVT HSTLEAMRGV TNDLLSVQGN 300
    TGPSWINKTE KAFFRGRDSR EERLQLVLLS KENPQLLDAG ITGYFFFQEK 350
    EKELGKAKLM GFFDFFKYKY QVNVDGTVAA YRYPYLMLGD SLVLKQESPY 400
    YEHFYVELRP WKHYVPIKRN LSDLLEKVKW AKENDEEAKR IAKEGQLTAR 450
    DLLQPPRLYC YYYRVLQKYA ERQVSKPMIR DGMERVPQPD DSTSVRQCHR 500
    KRPEREEL 508
    Length:508
    Mass (Da):58,701
    Last modified:May 10, 2005 - v1
    Checksum:iE04AB38138CC5DF9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti496 – 4961R → C in AAI00618. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC093594 mRNA. Translation: AAH93594.1.
    BC100617 mRNA. Translation: AAI00618.1.
    RefSeqiNP_001020294.3. NM_001025123.3.
    UniGeneiRn.98686.

    Genome annotation databases

    EnsembliENSRNOT00000009497; ENSRNOP00000009497; ENSRNOG00000007177.
    GeneIDi315664.
    KEGGirno:315664.
    UCSCiRGD:1562027. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC093594 mRNA. Translation: AAH93594.1 .
    BC100617 mRNA. Translation: AAI00618.1 .
    RefSeqi NP_001020294.3. NM_001025123.3.
    UniGenei Rn.98686.

    3D structure databases

    ProteinModelPortali Q566E5.
    SMRi Q566E5. Positions 22-134.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT90. Glycosyltransferase Family 90.

    Proteomic databases

    PaxDbi Q566E5.
    PRIDEi Q566E5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009497 ; ENSRNOP00000009497 ; ENSRNOG00000007177 .
    GeneIDi 315664.
    KEGGi rno:315664.
    UCSCi RGD:1562027. rat.

    Organism-specific databases

    CTDi 143888.
    RGDi 1562027. Kdelc2.

    Phylogenomic databases

    eggNOGi NOG248922.
    GeneTreei ENSGT00530000063132.
    HOGENOMi HOG000286007.
    HOVERGENi HBG081852.
    InParanoidi Q566E5.
    OMAi PVRYFYL.
    OrthoDBi EOG7XDBG0.
    PhylomeDBi Q566E5.
    TreeFami TF323280.

    Miscellaneous databases

    NextBioi 669617.
    PROi Q566E5.

    Gene expression databases

    Genevestigatori Q566E5.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR006598. LipoPS_modifying.
    [Graphical view ]
    Pfami PF00630. Filamin. 1 hit.
    PF05686. Glyco_transf_90. 1 hit.
    [Graphical view ]
    SMARTi SM00672. CAP10. 1 hit.
    SM00557. IG_FLMN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81296. SSF81296. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Prostate.

    Entry informationi

    Entry nameiKDEL2_RAT
    AccessioniPrimary (citable) accession number: Q566E5
    Secondary accession number(s): Q497C8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3