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Protein

Uroplakin-1b

Gene

Upk1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-1b
Short name:
UP1b
Alternative name(s):
Uroplakin Ib
Short name:
UPIb
Gene namesi
Name:Upk1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307806. Upk1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1514CytoplasmicSequence analysisAdd
BLAST
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Topological domaini37 – 5923ExtracellularSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 866CytoplasmicSequence analysis
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST
Topological domaini108 – 229122ExtracellularSequence analysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence analysisAdd
BLAST
Topological domaini251 – 26010CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 260259Uroplakin-1bPRO_0000219292Add
BLAST

Post-translational modificationi

N-glycosylated with high-mannose oligosaccharides.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ566D0.

Expressioni

Gene expression databases

GenevisibleiQ566D0. RN.

Interactioni

Subunit structurei

Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004315.

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
HOGENOMiHOG000230653.
HOVERGENiHBG054305.
InParanoidiQ566D0.
KOiK17347.
OMAiIGMCGIA.
OrthoDBiEOG7MD4QM.
PhylomeDBiQ566D0.
TreeFamiTF335659.

Family and domain databases

InterProiIPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q566D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDDSTVRC FQGLLIFGHV IVGMCGIALT AECIFFVSDQ HSLYPLLEAT
60 70 80 90 100
NNDDIFGAAW IGMFVGICLF CLSVLAIVGI MKSNRKILLA YFIMMFIVYG
110 120 130 140 150
FEVASCITAA TQRDFFTTNL FLKQMLMRYQ NNSPPTNDDK WKNSYVTKTW
160 170 180 190 200
DRLMLQDHCC GVNGPSDWQK YTSAFRVENS DADYPWPRQC CVMDKLQEPL
210 220 230 240 250
NLDACKLGVP GYYHSQGCYE LISGPMDRHA WGVAWFGFAI LCWTFWVLLG
260
TMFYWSRIEY
Length:260
Mass (Da):29,813
Last modified:January 23, 2007 - v3
Checksum:i97FAB4CE28937EBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093613 mRNA. Translation: AAH93613.1.
RefSeqiNP_001019424.1. NM_001024253.1.
XP_006248430.1. XM_006248368.2.
UniGeneiRn.9134.

Genome annotation databases

GeneIDi303924.
KEGGirno:303924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093613 mRNA. Translation: AAH93613.1.
RefSeqiNP_001019424.1. NM_001024253.1.
XP_006248430.1. XM_006248368.2.
UniGeneiRn.9134.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004315.

Proteomic databases

PaxDbiQ566D0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi303924.
KEGGirno:303924.

Organism-specific databases

CTDi7348.
RGDi1307806. Upk1b.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
HOGENOMiHOG000230653.
HOVERGENiHBG054305.
InParanoidiQ566D0.
KOiK17347.
OMAiIGMCGIA.
OrthoDBiEOG7MD4QM.
PhylomeDBiQ566D0.
TreeFamiTF335659.

Miscellaneous databases

NextBioi652351.
PROiQ566D0.

Gene expression databases

GenevisibleiQ566D0. RN.

Family and domain databases

InterProiIPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
SUPFAMiSSF48652. SSF48652. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiUPK1B_RAT
AccessioniPrimary (citable) accession number: Q566D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.