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Protein

Ankyrin repeat domain-containing protein 54

Gene

Ankrd54

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 54
Gene namesi
Name:Ankrd54
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309552. Ankrd54.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Midbody By similarity

  • Note: Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 299298Ankyrin repeat domain-containing protein 54PRO_0000274495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei62 – 621PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ566C8.
PRIDEiQ566C8.

PTM databases

iPTMnetiQ566C8.
PhosphoSiteiQ566C8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010821.

Interactioni

Subunit structurei

Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN. Forms a multiprotein complex with LYN and HCLS1 (By similarity). Interacts with TSN2, VAV1, DBNL AND LASP1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014413.

Structurei

3D structure databases

ProteinModelPortaliQ566C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati108 – 13730ANK 1Add
BLAST
Repeati141 – 17030ANK 2Add
BLAST
Repeati174 – 20330ANK 3Add
BLAST
Repeati207 – 23933ANK 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni140 – 240101LYN-bindingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi98 – 11619Nuclear localization signal (NLS)By similarityAdd
BLAST
Motifi282 – 29211Nuclear export signal (NES)By similarityAdd
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000008674.
HOVERGENiHBG080858.
InParanoidiQ566C8.
OrthoDBiEOG091G0WXS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q566C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATGGGAED ESRSGRSSSE GECAVAPEPL AEAGGLFSFA DLGAALGSGA
60 70 80 90 100
GLPGRAVGRA QSPLRYLQVL WQQDVEPRDE LRCKIPAGRL RRAARPHRRL
110 120 130 140 150
GPTGKEVHAL KRLRDSANAN DIETVQQLLE DGADPCAADD KGRTALHFAS
160 170 180 190 200
CNGNDQIVQL LLDHGADPNQ QDGLGNTPLH LAACTNHVPV ITTLLRGGAR
210 220 230 240 250
VDALDRAGRT PLHLAKSKLN ILQEGHSQCL EAVRLEVKQI IHMLREYLER
260 270 280 290
LGRHEQRERL DDLCTRLQMT STKEQVDEVT DLLASFTSLS LQMQSMEKR
Length:299
Mass (Da):32,492
Last modified:May 10, 2005 - v1
Checksum:i07F248F4575F000A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093616 mRNA. Translation: AAH93616.1.
RefSeqiNP_001020456.1. NM_001025285.1.
UniGeneiRn.28758.

Genome annotation databases

GeneIDi362957.
KEGGirno:362957.
UCSCiRGD:1309552. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093616 mRNA. Translation: AAH93616.1.
RefSeqiNP_001020456.1. NM_001025285.1.
UniGeneiRn.28758.

3D structure databases

ProteinModelPortaliQ566C8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014413.

PTM databases

iPTMnetiQ566C8.
PhosphoSiteiQ566C8.

Proteomic databases

PaxDbiQ566C8.
PRIDEiQ566C8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362957.
KEGGirno:362957.
UCSCiRGD:1309552. rat.

Organism-specific databases

CTDi129138.
RGDi1309552. Ankrd54.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000008674.
HOVERGENiHBG080858.
InParanoidiQ566C8.
OrthoDBiEOG091G0WXS.

Miscellaneous databases

PROiQ566C8.

Gene expression databases

BgeeiENSRNOG00000010821.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR54_RAT
AccessioniPrimary (citable) accession number: Q566C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.