ID RASF4_RAT Reviewed; 322 AA. AC Q566C5; DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot. DT 10-MAY-2005, sequence version 1. DT 24-JAN-2024, entry version 109. DE RecName: Full=Ras association domain-containing protein 4; GN Name=Rassf4; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Potential tumor suppressor. May act as a KRAS effector CC protein. May promote apoptosis and cell cycle arrest (By similarity). CC {ECO:0000250}. CC -!- SUBUNIT: Interacts directly with activated KRAS in a GTP-dependent CC manner. {ECO:0000250}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC093620; AAH93620.1; -; mRNA. DR RefSeq; NP_001019446.1; NM_001024275.1. DR RefSeq; XP_017448190.1; XM_017592701.1. DR AlphaFoldDB; Q566C5; -. DR STRING; 10116.ENSRNOP00000018101; -. DR PhosphoSitePlus; Q566C5; -. DR PaxDb; 10116-ENSRNOP00000018101; -. DR Ensembl; ENSRNOT00000018101.8; ENSRNOP00000018101.5; ENSRNOG00000013526.8. DR GeneID; 362423; -. DR KEGG; rno:362423; -. DR UCSC; RGD:1307785; rat. DR AGR; RGD:1307785; -. DR CTD; 83937; -. DR RGD; 1307785; Rassf4. DR eggNOG; KOG4239; Eukaryota. DR GeneTree; ENSGT00940000160176; -. DR HOGENOM; CLU_018893_1_0_1; -. DR InParanoid; Q566C5; -. DR OMA; RMCERQT; -. DR OrthoDB; 4211308at2759; -. DR PhylomeDB; Q566C5; -. DR TreeFam; TF319243; -. DR PRO; PR:Q566C5; -. DR Proteomes; UP000002494; Chromosome 4. DR Bgee; ENSRNOG00000013526; Expressed in lung and 20 other cell types or tissues. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IBA:GO_Central. DR CDD; cd17222; RA_RASSF4; 1. DR CDD; cd21894; SARAH_RASSF4; 1. DR InterPro; IPR000159; RA_dom. DR InterPro; IPR033614; RASSF1-6. DR InterPro; IPR033622; RASSF4_RA. DR InterPro; IPR011524; SARAH_dom. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR22738:SF4; RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 4; 1. DR PANTHER; PTHR22738; RASSF; 1. DR Pfam; PF16517; Nore1-SARAH; 1. DR Pfam; PF00788; RA; 1. DR SMART; SM00314; RA; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 1. DR PROSITE; PS50200; RA; 1. DR PROSITE; PS50951; SARAH; 1. DR Genevisible; Q566C5; RN. PE 2: Evidence at transcript level; KW Cell cycle; Phosphoprotein; Reference proteome; Tumor suppressor. FT CHAIN 1..322 FT /note="Ras association domain-containing protein 4" FT /id="PRO_0000240400" FT DOMAIN 175..263 FT /note="Ras-associating" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00166" FT DOMAIN 271..318 FT /note="SARAH" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00310" FT REGION 96..140 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 104..118 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 123..138 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 142 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q8CB96" SQ SEQUENCE 322 AA; 37125 MW; 0C23FEE5604BEFC9 CRC64; MKEDCSPSSH VPISDSKFIL KSELLSLLKT YNCYHEGRSF QLRHREEEGT LIIEGLLNIA WGLRRPIRLQ MQDDRERVHL PSATWVPERL SYLQKDASPQ DSKVPAEEPS TQPANKGEVS RDGSGPLQEE EEEVPQLMRT KSDASCIIQR RCKSRAPGEA QKIRRHRFSI NGHFYNHKTS VFTPAYGSVT NVRVNSTMTT QQVLTLLLNK FRVEDGPSEF ALYTVHESGE QTKLKDCEYP LISRILHGPC EKIVKIFLME ADLSEEVPHD VAQYIKFEMP VLDSFVEKLK EEEEREIIKL TMKFQALRLT MQQRLEQLVE AK //