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Q566C5

- RASF4_RAT

UniProt

Q566C5 - RASF4_RAT

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Protein

Ras association domain-containing protein 4

Gene

Rassf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest (By similarity).By similarity

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 4
Gene namesi
Name:Rassf4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1307785. Rassf4.

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Ras association domain-containing protein 4PRO_0000240400Add
BLAST

Proteomic databases

PaxDbiQ566C5.
PRIDEiQ566C5.

Expressioni

Gene expression databases

GenevestigatoriQ566C5.

Interactioni

Subunit structurei

Interacts directly with activated KRAS in a GTP-dependent manner.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018101.

Structurei

3D structure databases

ProteinModelPortaliQ566C5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 26389Ras-associatingPROSITE-ProRule annotationAdd
BLAST
Domaini271 – 31848SARAHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 SARAH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG316006.
GeneTreeiENSGT00510000046426.
HOGENOMiHOG000231738.
HOVERGENiHBG054302.
InParanoidiQ566C5.
KOiK09851.
OMAiCEKIARM.
OrthoDBiEOG7DVDBF.
PhylomeDBiQ566C5.
TreeFamiTF319243.

Family and domain databases

InterProiIPR000159. Ras-assoc.
IPR011524. SARAH_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00788. RA. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS50951. SARAH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q566C5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEDCSPSSH VPISDSKFIL KSELLSLLKT YNCYHEGRSF QLRHREEEGT
60 70 80 90 100
LIIEGLLNIA WGLRRPIRLQ MQDDRERVHL PSATWVPERL SYLQKDASPQ
110 120 130 140 150
DSKVPAEEPS TQPANKGEVS RDGSGPLQEE EEEVPQLMRT KSDASCIIQR
160 170 180 190 200
RCKSRAPGEA QKIRRHRFSI NGHFYNHKTS VFTPAYGSVT NVRVNSTMTT
210 220 230 240 250
QQVLTLLLNK FRVEDGPSEF ALYTVHESGE QTKLKDCEYP LISRILHGPC
260 270 280 290 300
EKIVKIFLME ADLSEEVPHD VAQYIKFEMP VLDSFVEKLK EEEEREIIKL
310 320
TMKFQALRLT MQQRLEQLVE AK
Length:322
Mass (Da):37,125
Last modified:May 10, 2005 - v1
Checksum:i0C23FEE5604BEFC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093620 mRNA. Translation: AAH93620.1.
RefSeqiNP_001019446.1. NM_001024275.1.
UniGeneiRn.195253.

Genome annotation databases

EnsembliENSRNOT00000018101; ENSRNOP00000018101; ENSRNOG00000013526.
GeneIDi362423.
KEGGirno:362423.
UCSCiRGD:1307785. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093620 mRNA. Translation: AAH93620.1 .
RefSeqi NP_001019446.1. NM_001024275.1.
UniGenei Rn.195253.

3D structure databases

ProteinModelPortali Q566C5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000018101.

Proteomic databases

PaxDbi Q566C5.
PRIDEi Q566C5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018101 ; ENSRNOP00000018101 ; ENSRNOG00000013526 .
GeneIDi 362423.
KEGGi rno:362423.
UCSCi RGD:1307785. rat.

Organism-specific databases

CTDi 83937.
RGDi 1307785. Rassf4.

Phylogenomic databases

eggNOGi NOG316006.
GeneTreei ENSGT00510000046426.
HOGENOMi HOG000231738.
HOVERGENi HBG054302.
InParanoidi Q566C5.
KOi K09851.
OMAi CEKIARM.
OrthoDBi EOG7DVDBF.
PhylomeDBi Q566C5.
TreeFami TF319243.

Miscellaneous databases

NextBioi 679867.
PROi Q566C5.

Gene expression databases

Genevestigatori Q566C5.

Family and domain databases

InterProi IPR000159. Ras-assoc.
IPR011524. SARAH_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00788. RA. 1 hit.
[Graphical view ]
SMARTi SM00314. RA. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS50200. RA. 1 hit.
PS50951. SARAH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRASF4_RAT
AccessioniPrimary (citable) accession number: Q566C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3