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Q566C5 (RASF4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras association domain-containing protein 4
Gene names
Name:Rassf4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest By similarity.

Subunit structure

Interacts directly with activated KRAS in a GTP-dependent manner By similarity.

Sequence similarities

Contains 1 Ras-associating domain.

Contains 1 SARAH domain.

Ontologies

Keywords
   Biological processCell cycle
   DiseaseTumor suppressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

signal transduction

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Ras association domain-containing protein 4
PRO_0000240400

Regions

Domain175 – 26389Ras-associating
Domain271 – 31848SARAH

Sequences

Sequence LengthMass (Da)Tools
Q566C5 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 0C23FEE5604BEFC9

FASTA32237,125
        10         20         30         40         50         60 
MKEDCSPSSH VPISDSKFIL KSELLSLLKT YNCYHEGRSF QLRHREEEGT LIIEGLLNIA 

        70         80         90        100        110        120 
WGLRRPIRLQ MQDDRERVHL PSATWVPERL SYLQKDASPQ DSKVPAEEPS TQPANKGEVS 

       130        140        150        160        170        180 
RDGSGPLQEE EEEVPQLMRT KSDASCIIQR RCKSRAPGEA QKIRRHRFSI NGHFYNHKTS 

       190        200        210        220        230        240 
VFTPAYGSVT NVRVNSTMTT QQVLTLLLNK FRVEDGPSEF ALYTVHESGE QTKLKDCEYP 

       250        260        270        280        290        300 
LISRILHGPC EKIVKIFLME ADLSEEVPHD VAQYIKFEMP VLDSFVEKLK EEEEREIIKL 

       310        320 
TMKFQALRLT MQQRLEQLVE AK 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC093620 mRNA. Translation: AAH93620.1.
RefSeqNP_001019446.1. NM_001024275.1.
XP_006237253.1. XM_006237191.1.
UniGeneRn.195253.

3D structure databases

ProteinModelPortalQ566C5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000018101.

Proteomic databases

PaxDbQ566C5.
PRIDEQ566C5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000018101; ENSRNOP00000018101; ENSRNOG00000013526.
GeneID362423.
KEGGrno:362423.
UCSCRGD:1307785. rat.

Organism-specific databases

CTD83937.
RGD1307785. Rassf4.

Phylogenomic databases

eggNOGNOG316006.
GeneTreeENSGT00510000046426.
HOGENOMHOG000231738.
HOVERGENHBG054302.
InParanoidQ566C5.
KOK09851.
OMACEKIARM.
OrthoDBEOG7DVDBF.
PhylomeDBQ566C5.
TreeFamTF319243.

Gene expression databases

GenevestigatorQ566C5.

Family and domain databases

InterProIPR000159. Ras-assoc.
IPR011524. SARAH_dom.
[Graphical view]
PfamPF00788. RA. 1 hit.
[Graphical view]
SMARTSM00314. RA. 1 hit.
[Graphical view]
PROSITEPS50200. RA. 1 hit.
PS50951. SARAH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio679867.
PROQ566C5.

Entry information

Entry nameRASF4_RAT
AccessionPrimary (citable) accession number: Q566C5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families