Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q566C5

- RASF4_RAT

UniProt

Q566C5 - RASF4_RAT

Protein

Ras association domain-containing protein 4

Gene

Rassf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest By similarity.By similarity

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. signal transduction Source: InterPro

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras association domain-containing protein 4
    Gene namesi
    Name:Rassf4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1307785. Rassf4.

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Ras association domain-containing protein 4PRO_0000240400Add
    BLAST

    Proteomic databases

    PaxDbiQ566C5.
    PRIDEiQ566C5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ566C5.

    Interactioni

    Subunit structurei

    Interacts directly with activated KRAS in a GTP-dependent manner.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000018101.

    Structurei

    3D structure databases

    ProteinModelPortaliQ566C5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini175 – 26389Ras-associatingPROSITE-ProRule annotationAdd
    BLAST
    Domaini271 – 31848SARAHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Ras-associating domain.PROSITE-ProRule annotation
    Contains 1 SARAH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG316006.
    GeneTreeiENSGT00510000046426.
    HOGENOMiHOG000231738.
    HOVERGENiHBG054302.
    InParanoidiQ566C5.
    KOiK09851.
    OMAiCEKIARM.
    OrthoDBiEOG7DVDBF.
    PhylomeDBiQ566C5.
    TreeFamiTF319243.

    Family and domain databases

    InterProiIPR000159. Ras-assoc.
    IPR011524. SARAH_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00788. RA. 1 hit.
    [Graphical view]
    SMARTiSM00314. RA. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50200. RA. 1 hit.
    PS50951. SARAH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q566C5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEDCSPSSH VPISDSKFIL KSELLSLLKT YNCYHEGRSF QLRHREEEGT    50
    LIIEGLLNIA WGLRRPIRLQ MQDDRERVHL PSATWVPERL SYLQKDASPQ 100
    DSKVPAEEPS TQPANKGEVS RDGSGPLQEE EEEVPQLMRT KSDASCIIQR 150
    RCKSRAPGEA QKIRRHRFSI NGHFYNHKTS VFTPAYGSVT NVRVNSTMTT 200
    QQVLTLLLNK FRVEDGPSEF ALYTVHESGE QTKLKDCEYP LISRILHGPC 250
    EKIVKIFLME ADLSEEVPHD VAQYIKFEMP VLDSFVEKLK EEEEREIIKL 300
    TMKFQALRLT MQQRLEQLVE AK 322
    Length:322
    Mass (Da):37,125
    Last modified:May 10, 2005 - v1
    Checksum:i0C23FEE5604BEFC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC093620 mRNA. Translation: AAH93620.1.
    RefSeqiNP_001019446.1. NM_001024275.1.
    XP_006237253.1. XM_006237191.1.
    UniGeneiRn.195253.

    Genome annotation databases

    EnsembliENSRNOT00000018101; ENSRNOP00000018101; ENSRNOG00000013526.
    GeneIDi362423.
    KEGGirno:362423.
    UCSCiRGD:1307785. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC093620 mRNA. Translation: AAH93620.1 .
    RefSeqi NP_001019446.1. NM_001024275.1.
    XP_006237253.1. XM_006237191.1.
    UniGenei Rn.195253.

    3D structure databases

    ProteinModelPortali Q566C5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000018101.

    Proteomic databases

    PaxDbi Q566C5.
    PRIDEi Q566C5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018101 ; ENSRNOP00000018101 ; ENSRNOG00000013526 .
    GeneIDi 362423.
    KEGGi rno:362423.
    UCSCi RGD:1307785. rat.

    Organism-specific databases

    CTDi 83937.
    RGDi 1307785. Rassf4.

    Phylogenomic databases

    eggNOGi NOG316006.
    GeneTreei ENSGT00510000046426.
    HOGENOMi HOG000231738.
    HOVERGENi HBG054302.
    InParanoidi Q566C5.
    KOi K09851.
    OMAi CEKIARM.
    OrthoDBi EOG7DVDBF.
    PhylomeDBi Q566C5.
    TreeFami TF319243.

    Miscellaneous databases

    NextBioi 679867.
    PROi Q566C5.

    Gene expression databases

    Genevestigatori Q566C5.

    Family and domain databases

    InterProi IPR000159. Ras-assoc.
    IPR011524. SARAH_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00788. RA. 1 hit.
    [Graphical view ]
    SMARTi SM00314. RA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50200. RA. 1 hit.
    PS50951. SARAH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRASF4_RAT
    AccessioniPrimary (citable) accession number: Q566C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3