Q56693 (PABC_VIBHA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminodeoxychorismate lyase
EC=4.1.3.38

Alternative name(s):
4-amino-4-deoxychorismate lyase
Short name=ADC lyase
Short name=ADCL

Gene names

Name:

pabC

Organism

Vibrio harveyi (Beneckea harveyi)

Taxonomic identifier

669 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio harveyi group

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.
Catalytic activity	4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 2/2.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Biological process	Folate biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Gene Ontology (GO)
Biological_process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	4-amino-4-deoxychorismate lyase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Aminodeoxychorismate lyase		PRO_0000103307
Amino acid modifications
	Modified residue	140	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q56693 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3AE5BEB9F398D1CD	FASTA	271	29,958
	10 20 30 40 50 60 MFWVNGLPQT HVPLGDRSFQ YGDGCFSTIK TKKGQLEHWQ AHVERMEACL TTLQIPFPDW 70 80 90 100 110 120 RTVLDWAMSA TLKDESAGIK IHISRGCGGR GYSPSGVEGP VVTISNFSFP AHYLAWQERG 130 140 150 160 170 180 VQLGVCETRL GIQPLLAGHK HNNRIEQVLA KAEIDGTEFA DAVTLNVQNH VIETTMANLF 190 200 210 220 230 240 WVKDEKVFTP GLCLSGVAGV MRRKVLEYLQ SEGYSVQVAD FTLTDLLDAD EVWMCNSLLG 250 260 270 VAPVSGISAP ENKIDFPIGK LTRRLQGNLN T

References

[1]	"Isolation of Vibrio harveyi acyl carrier protein and the fabG, acpP, and fabF genes involved in fatty acid biosynthesis." Shen Z., Byers D.M. J. Bacteriol. 178:571-573(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 33843 / 392 / MAV.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U39441 Genomic DNA. Translation: AAC43592.1.
PIR	T12054.
3D structure databases
ProteinModelPortal	Q56693.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00077; UER00150.
Family and domain databases
InterPro	IPR017824. Aminodeoxychorismate_lyase_IV. IPR001544. Aminotrans_IV. IPR018300. Aminotrans_IV_CS. [Graphical view]
PANTHER	PTHR11825. PTHR11825. 1 hit.
Pfam	PF01063. Aminotran_4. 1 hit. [Graphical view]
SUPFAM	SSF56752. Aminotrans_IV. 1 hit.
TIGRFAMs	TIGR03461. pabC_Proteo. 1 hit.
PROSITE	PS00770. AA_TRANSFER_CLASS_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PABC_VIBHA

Accession

Primary (citable) accession number: Q56693

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program