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Q56693

- PABC_VIBHA

UniProt

Q56693 - PABC_VIBHA

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Protein

Aminodeoxychorismate lyase

Gene
pabC
Organism
Vibrio harveyi (Beneckea harveyi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate By similarity.

Catalytic activityi

4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

GO - Molecular functioni

  1. 4-amino-4-deoxychorismate lyase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00077; UER00150.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminodeoxychorismate lyase (EC:4.1.3.38)
Alternative name(s):
4-amino-4-deoxychorismate lyase
Short name:
ADC lyase
Short name:
ADCL
Gene namesi
Name:pabC
OrganismiVibrio harveyi (Beneckea harveyi)
Taxonomic identifieri669 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Aminodeoxychorismate lyasePRO_0000103307Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei140 – 1401N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ56693.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR017824. Aminodeoxychorismate_lyase_IV.
IPR001544. Aminotrans_IV.
IPR018300. Aminotrans_IV_CS.
[Graphical view]
PANTHERiPTHR11825. PTHR11825. 1 hit.
PfamiPF01063. Aminotran_4. 1 hit.
[Graphical view]
SUPFAMiSSF56752. SSF56752. 1 hit.
TIGRFAMsiTIGR03461. pabC_Proteo. 1 hit.
PROSITEiPS00770. AA_TRANSFER_CLASS_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56693-1 [UniParc]FASTAAdd to Basket

« Hide

MFWVNGLPQT HVPLGDRSFQ YGDGCFSTIK TKKGQLEHWQ AHVERMEACL    50
TTLQIPFPDW RTVLDWAMSA TLKDESAGIK IHISRGCGGR GYSPSGVEGP 100
VVTISNFSFP AHYLAWQERG VQLGVCETRL GIQPLLAGHK HNNRIEQVLA 150
KAEIDGTEFA DAVTLNVQNH VIETTMANLF WVKDEKVFTP GLCLSGVAGV 200
MRRKVLEYLQ SEGYSVQVAD FTLTDLLDAD EVWMCNSLLG VAPVSGISAP 250
ENKIDFPIGK LTRRLQGNLN T 271
Length:271
Mass (Da):29,958
Last modified:November 1, 1996 - v1
Checksum:i3AE5BEB9F398D1CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39441 Genomic DNA. Translation: AAC43592.1.
PIRiT12054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39441 Genomic DNA. Translation: AAC43592.1 .
PIRi T12054.

3D structure databases

ProteinModelPortali Q56693.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00150 .

Family and domain databases

InterProi IPR017824. Aminodeoxychorismate_lyase_IV.
IPR001544. Aminotrans_IV.
IPR018300. Aminotrans_IV_CS.
[Graphical view ]
PANTHERi PTHR11825. PTHR11825. 1 hit.
Pfami PF01063. Aminotran_4. 1 hit.
[Graphical view ]
SUPFAMi SSF56752. SSF56752. 1 hit.
TIGRFAMsi TIGR03461. pabC_Proteo. 1 hit.
PROSITEi PS00770. AA_TRANSFER_CLASS_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of Vibrio harveyi acyl carrier protein and the fabG, acpP, and fabF genes involved in fatty acid biosynthesis."
    Shen Z., Byers D.M.
    J. Bacteriol. 178:571-573(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 33843 / 392 / MAV.

Entry informationi

Entry nameiPABC_VIBHA
AccessioniPrimary (citable) accession number: Q56693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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