Reviewed, UniProtKB/Swiss-Prot Q56686 (CPDP_VIBFI)

Names and origin

Protein names

Recommended name:
    3',5'-cyclic-nucleotide phosphodiesterase
      Short name=PDEase
      Short name=3':5'-CNP
    EC=3.1.4.17

Gene names

Name:

cpdP

Organism

Vibrio fischeri

Taxonomic identifier

668 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Seems to allow the organism to grow on cAMP.
Catalytic activity	Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the cAMP phosphodiesterase class-II family.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Ligand	cAMP
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	cAMP catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3',5'-cyclic-AMP phosphodiesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 330	308	3',5'-cyclic-nucleotide phosphodiesterase		PRO_0000023354

Sequences

	Sequence		Length	Mass (Da)
	Q56686-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B87127EE2CE213D4	FASTA	330	36,089
	10 20 30 40 50 60 MFKNKLAVLF TCLSVFSFSA QSGSFDTVTL GSKGGIQDGN LTAFLIKSEA DSNFVMLDAG 70 80 90 100 110 120 SVVNGLIVSE QKGAFKDITV PDSSPYTKVG YLLKDRIKGY FISHAHLDHV AGLIISSPDD 130 140 150 160 170 180 SKKPIYGLAA TNKDLMKNYF NWSAWPNFGN KGEGFKLNKY NYVDLQPGVW SPVAETTMSV 190 200 210 220 230 240 VSLPLSHSGG QSTVFILKDS EGDVFAYFGD TGPDEVEKSS AMRTAWSVLA PFVKQGKLKG 250 260 270 280 290 300 IIIEVSFTNE TPDKSLFGHL TPNWLVKELS VLEDMNGKGS LKDLNVAISH IKYSLKNSED 310 320 330 PKVIIKKQLV EVNDLGVNFI FPEQGDSLQF

References

[1]	"Characterization of a periplasmic 3':5'-cyclic nucleotide phosphodiesterase gene, cpdP, from the marine symbiotic bacterium Vibrio fischeri." Dunlap P.V., Callahan S.M. J. Bacteriol. 175:4615-4624(1993) [PubMed: 8393003] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MJ-1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L11527 Genomic DNA. Translation: AAA27513.1.
PIR	A40602.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.1.4.17. 350.
Family and domain databases
InterPro	IPR000396. Pdiesterase2. [Graphical view]
Pfam	PF02112. PDEase_II. 1 hit. [Graphical view]
PIRSF	PIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTS	PR00388. PDIESTERASE2.
ProDom	PD010003. Pdiesterase2_lac. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00607. PDEASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CPDP_VIBFI

Accession

Primary (citable) accession number: Q56686

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)