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Protein

3',5'-cyclic-nucleotide phosphodiesterase

Gene

cpdP

Organism
Aliivibrio fischeri (Vibrio fischeri)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Seems to allow the organism to grow on cAMP.

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: InterPro

GO - Biological processi

  1. cAMP catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic-nucleotide phosphodiesterase (EC:3.1.4.17)
Short name:
3':5'-CNP
Short name:
PDEase
Gene namesi
Name:cpdP
OrganismiAliivibrio fischeri (Vibrio fischeri)
Taxonomic identifieri668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio

Subcellular locationi

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 3303083',5'-cyclic-nucleotide phosphodiesterasePRO_0000023354Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ56686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR024225. cAMP-PdiesteraseII_CS.
IPR000396. Pdiesterase2.
[Graphical view]
PfamiPF02112. PDEase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTSiPR00388. PDIESTERASE2.
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00607. PDEASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKNKLAVLF TCLSVFSFSA QSGSFDTVTL GSKGGIQDGN LTAFLIKSEA
60 70 80 90 100
DSNFVMLDAG SVVNGLIVSE QKGAFKDITV PDSSPYTKVG YLLKDRIKGY
110 120 130 140 150
FISHAHLDHV AGLIISSPDD SKKPIYGLAA TNKDLMKNYF NWSAWPNFGN
160 170 180 190 200
KGEGFKLNKY NYVDLQPGVW SPVAETTMSV VSLPLSHSGG QSTVFILKDS
210 220 230 240 250
EGDVFAYFGD TGPDEVEKSS AMRTAWSVLA PFVKQGKLKG IIIEVSFTNE
260 270 280 290 300
TPDKSLFGHL TPNWLVKELS VLEDMNGKGS LKDLNVAISH IKYSLKNSED
310 320 330
PKVIIKKQLV EVNDLGVNFI FPEQGDSLQF
Length:330
Mass (Da):36,089
Last modified:November 1, 1996 - v1
Checksum:iB87127EE2CE213D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11527 Genomic DNA. Translation: AAA27513.1.
PIRiA40602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11527 Genomic DNA. Translation: AAA27513.1.
PIRiA40602.

3D structure databases

ProteinModelPortaliQ56686.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR024225. cAMP-PdiesteraseII_CS.
IPR000396. Pdiesterase2.
[Graphical view]
PfamiPF02112. PDEase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTSiPR00388. PDIESTERASE2.
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00607. PDEASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of a periplasmic 3':5'-cyclic nucleotide phosphodiesterase gene, cpdP, from the marine symbiotic bacterium Vibrio fischeri."
    Dunlap P.V., Callahan S.M.
    J. Bacteriol. 175:4615-4624(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MJ-1.

Entry informationi

Entry nameiCPDP_ALIFS
AccessioniPrimary (citable) accession number: Q56686
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.