Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.By similarity

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase (EC:2.7.1.24)
Alternative name(s):
Dephosphocoenzyme A kinase
Gene namesi
Name:coaE
Ordered Locus Names:TTHA0926
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001730231 – 203Dephospho-CoA kinaseAdd BLAST203

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0926.

Structurei

Secondary structure

1203
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 15Combined sources7
Helixi21 – 30Combined sources10
Beta strandi35 – 37Combined sources3
Helixi38 – 48Combined sources11
Helixi50 – 56Combined sources7
Helixi58 – 60Combined sources3
Helixi68 – 75Combined sources8
Helixi79 – 102Combined sources24
Beta strandi107 – 112Combined sources6
Turni114 – 120Combined sources7
Helixi122 – 124Combined sources3
Beta strandi125 – 131Combined sources7
Helixi135 – 143Combined sources9
Helixi151 – 157Combined sources7
Helixi163 – 169Combined sources7
Beta strandi171 – 174Combined sources4
Helixi179 – 192Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UF9X-ray2.80A/B/C1-198[»]
ProteinModelPortaliQ56416.
SMRiQ56416.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56416.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 203DPCKAdd BLAST194

Sequence similaritiesi

Belongs to the CoaE family.Curated

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
HOGENOMiHOG000020768.
KOiK00859.
OMAiVSCDSEK.
PhylomeDBiQ56416.

Family and domain databases

CDDicd02022. DPCK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHEAKHPII IGITGNIGSG KSTVAALLRS WGYPVLDLDA LAARARENKE
60 70 80 90 100
EELKRLFPEA VVGGRLDRRA LARLVFSDPE RLKALEAVVH PEVRRLLMEE
110 120 130 140 150
LSRLEAPLVF LEIPLLFEKG WEGRLHGTLL VAAPLEERVR RVMARSGLSR
160 170 180 190 200
EEVLARERAQ MPEEEKRKRA TWVLENTGSL EDLERALKAV LAELTGGAKG

GRG
Length:203
Mass (Da):22,590
Last modified:March 29, 2005 - v2
Checksum:i7CEE89F1D7D78076
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182 – 203DLERA…KGGRG → AWKGP (PubMed:2176725).CuratedAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33159 Genomic DNA. Translation: AAA27493.1.
AP008226 Genomic DNA. Translation: BAD70749.1.
PIRiS27735.
RefSeqiWP_011173002.1. NC_006461.1.
YP_144192.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70749; BAD70749; BAD70749.
GeneIDi3169510.
KEGGittj:TTHA0926.
PATRICi23956814. VBITheThe93045_0909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33159 Genomic DNA. Translation: AAA27493.1.
AP008226 Genomic DNA. Translation: BAD70749.1.
PIRiS27735.
RefSeqiWP_011173002.1. NC_006461.1.
YP_144192.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UF9X-ray2.80A/B/C1-198[»]
ProteinModelPortaliQ56416.
SMRiQ56416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0926.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70749; BAD70749; BAD70749.
GeneIDi3169510.
KEGGittj:TTHA0926.
PATRICi23956814. VBITheThe93045_0909.

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
HOGENOMiHOG000020768.
KOiK00859.
OMAiVSCDSEK.
PhylomeDBiQ56416.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Miscellaneous databases

EvolutionaryTraceiQ56416.

Family and domain databases

CDDicd02022. DPCK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOAE_THET8
AccessioniPrimary (citable) accession number: Q56416
Secondary accession number(s): Q5SJT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 29, 2005
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.