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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.By similarity

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-956-MONOMER.
UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase (EC:2.7.1.24)
Alternative name(s):
Dephosphocoenzyme A kinase
Gene namesi
Name:coaE
Ordered Locus Names:TTHA0926
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Dephospho-CoA kinasePRO_0000173023Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0926.

Structurei

Secondary structure

1
203
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 157Combined sources
Helixi21 – 3010Combined sources
Beta strandi35 – 373Combined sources
Helixi38 – 4811Combined sources
Helixi50 – 567Combined sources
Helixi58 – 603Combined sources
Helixi68 – 758Combined sources
Helixi79 – 10224Combined sources
Beta strandi107 – 1126Combined sources
Turni114 – 1207Combined sources
Helixi122 – 1243Combined sources
Beta strandi125 – 1317Combined sources
Helixi135 – 1439Combined sources
Helixi151 – 1577Combined sources
Helixi163 – 1697Combined sources
Beta strandi171 – 1744Combined sources
Helixi179 – 19214Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UF9X-ray2.80A/B/C1-198[»]
ProteinModelPortaliQ56416.
SMRiQ56416. Positions 6-196.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56416.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 203194DPCKAdd
BLAST

Sequence similaritiesi

Belongs to the CoaE family.Curated

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
HOGENOMiHOG000020768.
KOiK00859.
OMAiTVENTKM.
OrthoDBiEOG6HTP3H.
PhylomeDBiQ56416.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHEAKHPII IGITGNIGSG KSTVAALLRS WGYPVLDLDA LAARARENKE
60 70 80 90 100
EELKRLFPEA VVGGRLDRRA LARLVFSDPE RLKALEAVVH PEVRRLLMEE
110 120 130 140 150
LSRLEAPLVF LEIPLLFEKG WEGRLHGTLL VAAPLEERVR RVMARSGLSR
160 170 180 190 200
EEVLARERAQ MPEEEKRKRA TWVLENTGSL EDLERALKAV LAELTGGAKG

GRG
Length:203
Mass (Da):22,590
Last modified:March 29, 2005 - v2
Checksum:i7CEE89F1D7D78076
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 20322DLERA…KGGRG → AWKGP (PubMed:2176725).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33159 Genomic DNA. Translation: AAA27493.1.
AP008226 Genomic DNA. Translation: BAD70749.1.
PIRiS27735.
RefSeqiWP_011173002.1. NC_006461.1.
YP_144192.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70749; BAD70749; BAD70749.
GeneIDi3169510.
KEGGittj:TTHA0926.
PATRICi23956814. VBITheThe93045_0909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33159 Genomic DNA. Translation: AAA27493.1.
AP008226 Genomic DNA. Translation: BAD70749.1.
PIRiS27735.
RefSeqiWP_011173002.1. NC_006461.1.
YP_144192.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UF9X-ray2.80A/B/C1-198[»]
ProteinModelPortaliQ56416.
SMRiQ56416. Positions 6-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0926.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70749; BAD70749; BAD70749.
GeneIDi3169510.
KEGGittj:TTHA0926.
PATRICi23956814. VBITheThe93045_0909.

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
HOGENOMiHOG000020768.
KOiK00859.
OMAiTVENTKM.
OrthoDBiEOG6HTP3H.
PhylomeDBiQ56416.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.
BioCyciTTHE300852:GH8R-956-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ56416.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence of IS1000, a putative insertion sequence from Thermus thermophilus HB8."
    Ashby M.K., Bergquist P.L.
    Plasmid 24:1-11(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiCOAE_THET8
AccessioniPrimary (citable) accession number: Q56416
Secondary accession number(s): Q5SJT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 29, 2005
Last modified: November 11, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.