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Protein

Cytochrome c oxidase subunit 1

Gene

cbaA

Organism
Thermus thermophilus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • hemeBy similarityNote: Binds 2 heme groups.By similarity
  • Cu cationBy similarityNote: Binds a copper B center.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49Iron (heme A3 axial ligand)By similarity1
Metal bindingi51Iron (heme A axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c ba(3) subunit I
Cytochrome c oxidase polypeptide I
Cytochrome cba3 subunit 1
Gene namesi
Name:cbaA
OrganismiThermus thermophilus
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000183463‹1 – ›108Cytochrome c oxidase subunit 1Add BLAST›108

Interactioni

Protein-protein interaction databases

IntActiQ56408. 2 interactors.
STRINGi262724.TTC0770.

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 31Combined sources23
Helixi34 – 36Combined sources3
Helixi37 – 40Combined sources4
Helixi45 – 53Combined sources9
Turni54 – 56Combined sources3
Helixi57 – 64Combined sources8
Helixi66 – 74Combined sources9
Helixi80 – 108Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XMEX-ray2.30A1-108[»]
ProteinModelPortaliQ56408.
SMRiQ56408.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56408.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107RQ2. Bacteria.
COG0843. LUCA.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q56408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IRALPWDNPA FVAPVLGLLG FIPGGAGGIV NASFTLDYVV HNTAWVPGHF
60 70 80 90 100
HLQVASLVTL TAMGSLYWLL PNLTGKPISD AQRRLGLAVV WLWFLGMMIM

AVGLHWAG
Length:108
Mass (Da):11,634
Last modified:March 29, 2005 - v2
Checksum:i7DEB6C38DD575368
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1081

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z84206 Genomic DNA. Translation: CAB06339.1.
PIRiT52481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z84206 Genomic DNA. Translation: CAB06339.1.
PIRiT52481.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XMEX-ray2.30A1-108[»]
ProteinModelPortaliQ56408.
SMRiQ56408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ56408. 2 interactors.
STRINGi262724.TTC0770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4107RQ2. Bacteria.
COG0843. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00705.

Miscellaneous databases

EvolutionaryTraceiQ56408.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_THETH
AccessioniPrimary (citable) accession number: Q56408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 29, 2005
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.