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Q56408 (COX1_THETH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c ba(3) subunit I
Cytochrome c oxidase polypeptide I
Cytochrome cba3 subunit 1
Gene names
Name:cbaA
OrganismThermus thermophilus
Taxonomic identifier274 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length108 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Binds 2 heme groups By similarity.

Copper B By similarity.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›108›108Cytochrome c oxidase subunit 1
PRO_0000183463

Regions

Transmembrane10 – 3021Helical; Potential
Transmembrane50 – 7021Helical; Potential
Transmembrane85 – 10521Helical; Potential

Sites

Metal binding491Iron (heme A3 axial ligand) By similarity
Metal binding511Iron (heme A axial ligand) By similarity

Experimental info

Non-terminal residue11
Non-terminal residue1081

Secondary structure

............. 108
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q56408 [UniParc].

Last modified March 29, 2005. Version 2.
Checksum: 7DEB6C38DD575368

FASTA10811,634
        10         20         30         40         50         60 
IRALPWDNPA FVAPVLGLLG FIPGGAGGIV NASFTLDYVV HNTAWVPGHF HLQVASLVTL 

        70         80         90        100 
TAMGSLYWLL PNLTGKPISD AQRRLGLAVV WLWFLGMMIM AVGLHWAG 

« Hide

References

[1]"Ribosomal protein S15 from Thermus thermophilus -- cloning, sequencing, overexpression of the gene and RNA-binding properties of the protein."
Serganov A., Rak A., Garber M.B., Reinbolt J., Ehresmann B., Ehresmann C., Grunberg-Manago M., Portier C.
Eur. J. Biochem. 246:291-300(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: VK1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z84206 Genomic DNA. Translation: CAB06339.1.
PIRT52481.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1XMEX-ray2.30A1-108[»]
ProteinModelPortalQ56408.
SMRQ56408. Positions 1-108.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ56408. 2 interactions.
STRING262724.TTC0770.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ56408.

Entry information

Entry nameCOX1_THETH
AccessionPrimary (citable) accession number: Q56408
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 29, 2005
Last modified: April 16, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways