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Protein

Cytochrome c oxidase subunit 1

Gene

cbaA

Organism
Thermus thermophilus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • hemeBy similarityNote: Binds 2 heme groups.By similarity
  • Cu cationBy similarityNote: Binds a copper B center.By similarity

Pathway:ioxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi49 – 491Iron (heme A3 axial ligand)By similarity
Metal bindingi51 – 511Iron (heme A axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c ba(3) subunit I
Cytochrome c oxidase polypeptide I
Cytochrome cba3 subunit 1
Gene namesi
Name:cbaA
OrganismiThermus thermophilus
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Transmembranei50 – 7021HelicalSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›108›108Cytochrome c oxidase subunit 1PRO_0000183463Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ56408. 2 interactions.
STRINGi262724.TTC0770.

Structurei

Secondary structure

1
108
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 3123Combined sources
Helixi34 – 363Combined sources
Helixi37 – 404Combined sources
Helixi45 – 539Combined sources
Turni54 – 563Combined sources
Helixi57 – 648Combined sources
Helixi66 – 749Combined sources
Helixi80 – 10829Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XMEX-ray2.30A1-108[»]
ProteinModelPortaliQ56408.
SMRiQ56408. Positions 1-108.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56408.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q56408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IRALPWDNPA FVAPVLGLLG FIPGGAGGIV NASFTLDYVV HNTAWVPGHF
60 70 80 90 100
HLQVASLVTL TAMGSLYWLL PNLTGKPISD AQRRLGLAVV WLWFLGMMIM

AVGLHWAG
Length:108
Mass (Da):11,634
Last modified:March 29, 2005 - v2
Checksum:i7DEB6C38DD575368
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei108 – 1081

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z84206 Genomic DNA. Translation: CAB06339.1.
PIRiT52481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z84206 Genomic DNA. Translation: CAB06339.1.
PIRiT52481.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XMEX-ray2.30A1-108[»]
ProteinModelPortaliQ56408.
SMRiQ56408. Positions 1-108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ56408. 2 interactions.
STRINGi262724.TTC0770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Miscellaneous databases

EvolutionaryTraceiQ56408.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Ribosomal protein S15 from Thermus thermophilus -- cloning, sequencing, overexpression of the gene and RNA-binding properties of the protein."
    Serganov A., Rak A., Garber M.B., Reinbolt J., Ehresmann B., Ehresmann C., Grunberg-Manago M., Portier C.
    Eur. J. Biochem. 246:291-300(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: VK1.

Entry informationi

Entry nameiCOX1_THETH
AccessioniPrimary (citable) accession number: Q56408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 29, 2005
Last modified: January 7, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.