Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-type ATP synthase alpha chain

Gene

atpA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi228 – 235ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
V-type ATP synthase alpha chain (EC:3.6.3.14)
Alternative name(s):
V-ATPase subunit A
Gene namesi
Name:atpA
Ordered Locus Names:TTHA1273
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001446191 – 578V-type ATP synthase alpha chainAdd BLAST578

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
atpBQ564042EBI-7260009,EBI-7260036

Protein-protein interaction databases

IntActiQ56403. 3 interactors.
MINTiMINT-7297929.
STRINGi300852.TTHA1273.

Structurei

Secondary structure

1578
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 10Combined sources8
Beta strandi13 – 18Combined sources6
Beta strandi26 – 30Combined sources5
Turni31 – 34Combined sources4
Beta strandi35 – 43Combined sources9
Beta strandi46 – 53Combined sources8
Beta strandi63 – 76Combined sources14
Helixi91 – 98Combined sources8
Beta strandi113 – 115Combined sources3
Beta strandi117 – 121Combined sources5
Beta strandi134 – 140Combined sources7
Beta strandi143 – 148Combined sources6
Beta strandi155 – 160Combined sources6
Beta strandi163 – 166Combined sources4
Beta strandi172 – 175Combined sources4
Beta strandi185 – 188Combined sources4
Beta strandi196 – 199Combined sources4
Beta strandi203 – 205Combined sources3
Helixi210 – 213Combined sources4
Beta strandi223 – 226Combined sources4
Helixi234 – 244Combined sources11
Beta strandi248 – 257Combined sources10
Helixi259 – 266Combined sources8
Helixi269 – 271Combined sources3
Turni275 – 277Combined sources3
Beta strandi278 – 281Combined sources4
Helixi282 – 284Combined sources3
Beta strandi285 – 291Combined sources7
Helixi296 – 315Combined sources20
Beta strandi319 – 322Combined sources4
Helixi327 – 340Combined sources14
Beta strandi347 – 350Combined sources4
Helixi354 – 362Combined sources9
Beta strandi366 – 369Combined sources4
Beta strandi375 – 383Combined sources9
Turni387 – 389Combined sources3
Helixi394 – 400Combined sources7
Beta strandi404 – 406Combined sources3
Helixi411 – 416Combined sources6
Turni424 – 426Combined sources3
Beta strandi428 – 431Combined sources4
Helixi432 – 442Combined sources11
Helixi447 – 462Combined sources16
Turni463 – 472Combined sources10
Helixi473 – 475Combined sources3
Helixi478 – 494Combined sources17
Beta strandi499 – 501Combined sources3
Turni502 – 505Combined sources4
Helixi509 – 530Combined sources22
Turni531 – 533Combined sources3
Helixi536 – 539Combined sources4
Helixi545 – 549Combined sources5
Beta strandi556 – 558Combined sources3
Helixi559 – 576Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A5CX-ray4.51A/B/C/I/J/K1-578[»]
3A5DX-ray4.80A/B/C/I/J/K1-578[»]
3GQBX-ray2.80A/C1-578[»]
3J0Jelectron microscopy9.70A/B/C1-578[»]
3W3AX-ray3.90A/B/C/I/J/K1-577[»]
5GARelectron microscopy6.40A/B/C1-577[»]
5GASelectron microscopy9.50A/B/C1-577[»]
ProteinModelPortaliQ56403.
SMRiQ56403.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56403.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiENOG4108JIQ. Bacteria.
COG1155. LUCA.
HOGENOMiHOG000161057.
KOiK02117.
OMAiYSPYDRF.
PhylomeDBiQ56403.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00309. ATP_synth_A_arch. 1 hit.
InterProiIPR031686. ATP-synth_a_Xtn.
IPR020003. ATPase_a/bsu_AS.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1/V1_bsu_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
PF16886. ATP-synt_ab_Xtn. 1 hit.
[Graphical view]
SUPFAMiSSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQGVIQKIA GPAVIAKGML GARMYDICKV GEEGLVGEII RLDGDTAFVQ
60 70 80 90 100
VYEDTSGLKV GEPVVSTGLP LAVELGPGML NGIYDGIQRP LERIREKTGI
110 120 130 140 150
YITRGVVVHA LDREKKWAWT PMVKPGDEVR GGMVLGTVPE FGFTHKILVP
160 170 180 190 200
PDVRGRVKEV KPAGEYTVEE PVVVLEDGTE LKMYHTWPVR RARPVQRKLD
210 220 230 240 250
PNTPFLTGMR ILDVLFPVAM GGTAAIPGPF GSGKTVTQQS LAKWSNADVV
260 270 280 290 300
VYVGCGERGN EMTDVLVEFP ELTDPKTGGP LMHRTVLIAN TSNMPVAARE
310 320 330 340 350
ASIYVGVTIA EYFRDQGFSV ALMADSTSRW AEALREISSR LEEMPAEEGY
360 370 380 390 400
PPYLAARLAA FYERAGKVIT LGGEEGAVTI VGAVSPPGGD MSEPVTQSTL
410 420 430 440 450
RIVGAFWRLD ASLAFRRHFP AINWNGSYSL FTSALDPWYR ENVAEDYPEL
460 470 480 490 500
RDAISELLQR EAGLQEIVQL VGPDALQDAE RLVIEVGRII REDFLQQNAY
510 520 530 540 550
HEVDAYCSMK KAYGIMKMIL AFYKEAEAAI KRGVSIDEIL QLPVLERIGR
560 570
ARYVSEEEFP AYFEEAMKEI QGAFKALA
Length:578
Mass (Da):63,632
Last modified:June 20, 2003 - v2
Checksum:iB22A91ECA7B89970
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti577 – 578LA → GLKGERWTF in CAA45340 (PubMed:1836357).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63855 Genomic DNA. Translation: CAA45340.1.
D63799 Genomic DNA. Translation: BAA09873.2.
AP008226 Genomic DNA. Translation: BAD71096.1.
RefSeqiWP_011228560.1. NC_006461.1.
YP_144539.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71096; BAD71096; BAD71096.
GeneIDi3169043.
KEGGittj:TTHA1273.
PATRICi23957509. VBITheThe93045_1252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63855 Genomic DNA. Translation: CAA45340.1.
D63799 Genomic DNA. Translation: BAA09873.2.
AP008226 Genomic DNA. Translation: BAD71096.1.
RefSeqiWP_011228560.1. NC_006461.1.
YP_144539.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A5CX-ray4.51A/B/C/I/J/K1-578[»]
3A5DX-ray4.80A/B/C/I/J/K1-578[»]
3GQBX-ray2.80A/C1-578[»]
3J0Jelectron microscopy9.70A/B/C1-578[»]
3W3AX-ray3.90A/B/C/I/J/K1-577[»]
5GARelectron microscopy6.40A/B/C1-577[»]
5GASelectron microscopy9.50A/B/C1-577[»]
ProteinModelPortaliQ56403.
SMRiQ56403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ56403. 3 interactors.
MINTiMINT-7297929.
STRINGi300852.TTHA1273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71096; BAD71096; BAD71096.
GeneIDi3169043.
KEGGittj:TTHA1273.
PATRICi23957509. VBITheThe93045_1252.

Phylogenomic databases

eggNOGiENOG4108JIQ. Bacteria.
COG1155. LUCA.
HOGENOMiHOG000161057.
KOiK02117.
OMAiYSPYDRF.
PhylomeDBiQ56403.

Miscellaneous databases

EvolutionaryTraceiQ56403.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00309. ATP_synth_A_arch. 1 hit.
InterProiIPR031686. ATP-synth_a_Xtn.
IPR020003. ATPase_a/bsu_AS.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1/V1_bsu_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
PF16886. ATP-synt_ab_Xtn. 1 hit.
[Graphical view]
SUPFAMiSSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVATA_THET8
AccessioniPrimary (citable) accession number: Q56403
Secondary accession number(s): Q5SIU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 20, 2003
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.