Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-type ATP synthase alpha chain

Gene

atpA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi228 – 2358ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1307-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type ATP synthase alpha chain (EC:3.6.3.14)
Alternative name(s):
V-ATPase subunit A
Gene namesi
Name:atpA
Ordered Locus Names:TTHA1273
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578V-type ATP synthase alpha chainPRO_0000144619Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
atpBQ564042EBI-7260009,EBI-7260036

Protein-protein interaction databases

IntActiQ56403. 3 interactions.
MINTiMINT-7297929.
STRINGi300852.TTHA1273.

Structurei

Secondary structure

1
578
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 108Combined sources
Beta strandi13 – 186Combined sources
Beta strandi26 – 305Combined sources
Turni31 – 344Combined sources
Beta strandi35 – 439Combined sources
Beta strandi46 – 538Combined sources
Beta strandi63 – 7614Combined sources
Helixi91 – 988Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi117 – 1215Combined sources
Beta strandi134 – 1407Combined sources
Beta strandi143 – 1486Combined sources
Beta strandi155 – 1606Combined sources
Beta strandi163 – 1664Combined sources
Beta strandi172 – 1754Combined sources
Beta strandi185 – 1884Combined sources
Beta strandi196 – 1994Combined sources
Beta strandi203 – 2053Combined sources
Helixi210 – 2134Combined sources
Beta strandi223 – 2264Combined sources
Helixi234 – 24411Combined sources
Beta strandi248 – 25710Combined sources
Helixi259 – 2668Combined sources
Helixi269 – 2713Combined sources
Turni275 – 2773Combined sources
Beta strandi278 – 2814Combined sources
Helixi282 – 2843Combined sources
Beta strandi285 – 2917Combined sources
Helixi296 – 31520Combined sources
Beta strandi319 – 3224Combined sources
Helixi327 – 34014Combined sources
Beta strandi347 – 3504Combined sources
Helixi354 – 3629Combined sources
Beta strandi366 – 3694Combined sources
Beta strandi375 – 3839Combined sources
Turni387 – 3893Combined sources
Helixi394 – 4007Combined sources
Beta strandi404 – 4063Combined sources
Helixi411 – 4166Combined sources
Turni424 – 4263Combined sources
Beta strandi428 – 4314Combined sources
Helixi432 – 44211Combined sources
Helixi447 – 46216Combined sources
Turni463 – 47210Combined sources
Helixi473 – 4753Combined sources
Helixi478 – 49417Combined sources
Beta strandi499 – 5013Combined sources
Turni502 – 5054Combined sources
Helixi509 – 53022Combined sources
Turni531 – 5333Combined sources
Helixi536 – 5394Combined sources
Helixi545 – 5495Combined sources
Beta strandi556 – 5583Combined sources
Helixi559 – 57618Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A5CX-ray4.51A/B/C/I/J/K1-578[»]
3A5DX-ray4.80A/B/C/I/J/K1-578[»]
3GQBX-ray2.80A/C1-578[»]
3J0Jelectron microscopy9.70A/B/C1-578[»]
3W3AX-ray3.90A/B/C/I/J/K1-577[»]
5GARelectron microscopy6.40A/B/C1-577[»]
5GASelectron microscopy9.50A/B/C1-577[»]
ProteinModelPortaliQ56403.
SMRiQ56403. Positions 59-577.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56403.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiENOG4108JIQ. Bacteria.
COG1155. LUCA.
HOGENOMiHOG000161057.
KOiK02117.
OMAiYSPYDRF.
PhylomeDBiQ56403.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00309. ATP_synth_A_arch. 1 hit.
InterProiIPR031686. ATP-synt_a_Xtn.
IPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
PF16886. ATP-synt_ab_Xtn. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQGVIQKIA GPAVIAKGML GARMYDICKV GEEGLVGEII RLDGDTAFVQ
60 70 80 90 100
VYEDTSGLKV GEPVVSTGLP LAVELGPGML NGIYDGIQRP LERIREKTGI
110 120 130 140 150
YITRGVVVHA LDREKKWAWT PMVKPGDEVR GGMVLGTVPE FGFTHKILVP
160 170 180 190 200
PDVRGRVKEV KPAGEYTVEE PVVVLEDGTE LKMYHTWPVR RARPVQRKLD
210 220 230 240 250
PNTPFLTGMR ILDVLFPVAM GGTAAIPGPF GSGKTVTQQS LAKWSNADVV
260 270 280 290 300
VYVGCGERGN EMTDVLVEFP ELTDPKTGGP LMHRTVLIAN TSNMPVAARE
310 320 330 340 350
ASIYVGVTIA EYFRDQGFSV ALMADSTSRW AEALREISSR LEEMPAEEGY
360 370 380 390 400
PPYLAARLAA FYERAGKVIT LGGEEGAVTI VGAVSPPGGD MSEPVTQSTL
410 420 430 440 450
RIVGAFWRLD ASLAFRRHFP AINWNGSYSL FTSALDPWYR ENVAEDYPEL
460 470 480 490 500
RDAISELLQR EAGLQEIVQL VGPDALQDAE RLVIEVGRII REDFLQQNAY
510 520 530 540 550
HEVDAYCSMK KAYGIMKMIL AFYKEAEAAI KRGVSIDEIL QLPVLERIGR
560 570
ARYVSEEEFP AYFEEAMKEI QGAFKALA
Length:578
Mass (Da):63,632
Last modified:June 20, 2003 - v2
Checksum:iB22A91ECA7B89970
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti577 – 5782LA → GLKGERWTF in CAA45340 (PubMed:1836357).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63855 Genomic DNA. Translation: CAA45340.1.
D63799 Genomic DNA. Translation: BAA09873.2.
AP008226 Genomic DNA. Translation: BAD71096.1.
RefSeqiWP_011228560.1. NC_006461.1.
YP_144539.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71096; BAD71096; BAD71096.
GeneIDi3169043.
KEGGittj:TTHA1273.
PATRICi23957509. VBITheThe93045_1252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63855 Genomic DNA. Translation: CAA45340.1.
D63799 Genomic DNA. Translation: BAA09873.2.
AP008226 Genomic DNA. Translation: BAD71096.1.
RefSeqiWP_011228560.1. NC_006461.1.
YP_144539.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A5CX-ray4.51A/B/C/I/J/K1-578[»]
3A5DX-ray4.80A/B/C/I/J/K1-578[»]
3GQBX-ray2.80A/C1-578[»]
3J0Jelectron microscopy9.70A/B/C1-578[»]
3W3AX-ray3.90A/B/C/I/J/K1-577[»]
5GARelectron microscopy6.40A/B/C1-577[»]
5GASelectron microscopy9.50A/B/C1-577[»]
ProteinModelPortaliQ56403.
SMRiQ56403. Positions 59-577.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ56403. 3 interactions.
MINTiMINT-7297929.
STRINGi300852.TTHA1273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71096; BAD71096; BAD71096.
GeneIDi3169043.
KEGGittj:TTHA1273.
PATRICi23957509. VBITheThe93045_1252.

Phylogenomic databases

eggNOGiENOG4108JIQ. Bacteria.
COG1155. LUCA.
HOGENOMiHOG000161057.
KOiK02117.
OMAiYSPYDRF.
PhylomeDBiQ56403.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1307-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ56403.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00309. ATP_synth_A_arch. 1 hit.
InterProiIPR031686. ATP-synt_a_Xtn.
IPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
PF16886. ATP-synt_ab_Xtn. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVATA_THET8
AccessioniPrimary (citable) accession number: Q56403
Secondary accession number(s): Q5SIU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 20, 2003
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.