ID DPOL_THES9 Reviewed; 775 AA. AC Q56366; DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 13-SEP-2023, entry version 108. DE RecName: Full=DNA polymerase; DE EC=2.7.7.7; GN Name=pol; Synonyms=polA; OS Thermococcus sp. (strain 9oN-7). OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; OC Thermococcus. OX NCBI_TaxID=103799; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=8643567; DOI=10.1073/pnas.93.11.5281; RA Southworth M.W., Kong H., Kucera R.B., Ware J., Jannasch H.W., Perler F.B.; RT "Cloning of thermostable DNA polymerases from hyperthermophilic marine RT Archaea with emphasis on Thermococcus sp. 9oN-7 and mutations affecting 3'- RT 5' exonuclease activity."; RL Proc. Natl. Acad. Sci. U.S.A. 93:5281-5285(1996). CC -!- CATALYTIC ACTIVITY: CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, CC ChEBI:CHEBI:173112; EC=2.7.7.7; CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U47108; AAA88769.1; -; Genomic_DNA. DR PIR; S67920; S67920. DR PDB; 1QHT; X-ray; 2.10 A; A=1-775. DR PDB; 4K8X; X-ray; 2.28 A; A=1-775. DR PDB; 5OMQ; X-ray; 2.20 A; A=1-775. DR PDB; 5OMV; X-ray; 2.00 A; A=1-775. DR PDB; 6IS7; X-ray; 2.80 A; A/B=1-775. DR PDB; 6ISF; X-ray; 2.80 A; A/B=1-775. DR PDB; 6ISG; X-ray; 3.40 A; A=1-775. DR PDB; 6ISH; X-ray; 3.30 A; A=1-775. DR PDB; 6ISI; X-ray; 3.20 A; A=1-775. DR PDBsum; 1QHT; -. DR PDBsum; 4K8X; -. DR PDBsum; 5OMQ; -. DR PDBsum; 5OMV; -. DR PDBsum; 6IS7; -. DR PDBsum; 6ISF; -. DR PDBsum; 6ISG; -. DR PDBsum; 6ISH; -. DR PDBsum; 6ISI; -. DR AlphaFoldDB; Q56366; -. DR SMR; Q56366; -. DR EvolutionaryTrace; Q56366; -. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. DR CDD; cd05780; DNA_polB_Kod1_like_exo; 1. DR CDD; cd05536; POLBc_B3; 1. DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1. DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1. DR Gene3D; 1.10.287.690; Helix hairpin bin; 1. DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1. DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1. DR InterPro; IPR006172; DNA-dir_DNA_pol_B. DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS. DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc. DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR042087; DNA_pol_B_thumb. DR InterPro; IPR023211; DNA_pol_palm_dom_sf. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR036397; RNaseH_sf. DR NCBIfam; TIGR00592; pol2; 2. DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1. DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1. DR Pfam; PF00136; DNA_pol_B; 1. DR Pfam; PF03104; DNA_pol_B_exo1; 2. DR PRINTS; PR00106; DNAPOLB. DR SMART; SM00486; POLBc; 1. DR SUPFAM; SSF56672; DNA/RNA polymerases; 1. DR SUPFAM; SSF53098; Ribonuclease H-like; 1. DR PROSITE; PS00116; DNA_POLYMERASE_B; 1. PE 1: Evidence at protein level; KW 3D-structure; DNA replication; DNA-binding; DNA-directed DNA polymerase; KW Nucleotidyltransferase; Transferase. FT CHAIN 1..775 FT /note="DNA polymerase" FT /id="PRO_0000046489" FT STRAND 2..10 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 13..22 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 25..31 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 37..43 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 45..47 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 48..51 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 55..58 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 61..64 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 67..75 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 78..86 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 92..102 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 106..111 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 116..123 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 137..144 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 157..163 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 168..174 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 181..183 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 187..201 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 204..210 FT /evidence="ECO:0007829|PDB:5OMV" FT TURN 211..214 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 215..226 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 233..236 FT /evidence="ECO:0007829|PDB:6IS7" FT STRAND 240..244 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 247..251 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 255..259 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 260..267 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 275..283 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 292..301 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 302..304 FT /evidence="ECO:0007829|PDB:6ISH" FT HELIX 305..337 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 341..344 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 349..364 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 374..379 FT /evidence="ECO:0007829|PDB:5OMV" FT TURN 380..382 FT /evidence="ECO:0007829|PDB:1QHT" FT STRAND 395..405 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 408..416 FT /evidence="ECO:0007829|PDB:5OMV" FT TURN 420..422 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 431..433 FT /evidence="ECO:0007829|PDB:5OMV" FT TURN 435..437 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 440..442 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 448..469 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 473..497 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 507..531 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 535..540 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 543..547 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 553..567 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 568..570 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 577..590 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 593..598 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 603..608 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 609..611 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 613..615 FT /evidence="ECO:0007829|PDB:6ISF" FT HELIX 617..633 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 636..651 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 657..660 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 662..665 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 670..672 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 678..688 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 698..705 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 710..712 FT /evidence="ECO:0007829|PDB:5OMV" FT STRAND 714..716 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 717..719 FT /evidence="ECO:0007829|PDB:5OMV" FT TURN 722..724 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 729..734 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 737..745 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 746..748 FT /evidence="ECO:0007829|PDB:5OMV" FT HELIX 752..754 FT /evidence="ECO:0007829|PDB:5OMV" SQ SEQUENCE 775 AA; 89781 MW; 71525D63C0C9CD9D CRC64; MILDTDYITE NGKPVIRVFK KENGEFKIEY DRTFEPYFYA LLKDDSAIED VKKVTAKRHG TVVKVKRAEK VQKKFLGRPI EVWKLYFNHP QDVPAIRDRI RAHPAVVDIY EYDIPFAKRY LIDKGLIPME GDEELTMLAF DIETLYHEGE EFGTGPILMI SYADGSEARV ITWKKIDLPY VDVVSTEKEM IKRFLRVVRE KDPDVLITYN GDNFDFAYLK KRCEELGIKF TLGRDGSEPK IQRMGDRFAV EVKGRIHFDL YPVIRRTINL PTYTLEAVYE AVFGKPKEKV YAEEIAQAWE SGEGLERVAR YSMEDAKVTY ELGREFFPME AQLSRLIGQS LWDVSRSSTG NLVEWFLLRK AYKRNELAPN KPDERELARR RGGYAGGYVK EPERGLWDNI VYLDFRSLYP SIIITHNVSP DTLNREGCKE YDVAPEVGHK FCKDFPGFIP SLLGDLLEER QKIKRKMKAT VDPLEKKLLD YRQRAIKILA NSFYGYYGYA KARWYCKECA ESVTAWGREY IEMVIRELEE KFGFKVLYAD TDGLHATIPG ADAETVKKKA KEFLKYINPK LPGLLELEYE GFYVRGFFVT KKKYAVIDEE GKITTRGLEI VRRDWSEIAK ETQARVLEAI LKHGDVEEAV RIVKEVTEKL SKYEVPPEKL VIHEQITRDL RDYKATGPHV AVAKRLAARG VKIRPGTVIS YIVLKGSGRI GDRAIPADEF DPTKHRYDAE YYIENQVLPA VERILKAFGY RKEDLRYQKT KQVGLGAWLK VKGKK //