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Q56366

- DPOL_THES9

UniProt

Q56366 - DPOL_THES9

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Protein
DNA polymerase
Gene
pol, polA
Organism
Thermococcus sp. (strain 9oN-7)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase (EC:2.7.7.7)
Gene namesi
Name:pol
Synonyms:polA
OrganismiThermococcus sp. (strain 9oN-7)
Taxonomic identifieri103799 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775DNA polymerase
PRO_0000046489Add
BLAST

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 109
Beta strandi13 – 2210
Beta strandi25 – 317
Beta strandi37 – 437
Helixi45 – 473
Helixi48 – 514
Beta strandi55 – 584
Beta strandi61 – 644
Beta strandi67 – 759
Beta strandi78 – 869
Helixi92 – 10110
Beta strandi106 – 1116
Helixi116 – 1238
Beta strandi137 – 1448
Beta strandi157 – 1637
Beta strandi168 – 1747
Beta strandi179 – 1835
Helixi187 – 20115
Beta strandi204 – 2107
Turni211 – 2144
Helixi215 – 22511
Beta strandi240 – 2445
Beta strandi247 – 2515
Beta strandi255 – 2595
Helixi260 – 2678
Helixi275 – 2839
Helixi292 – 2998
Helixi305 – 33733
Helixi341 – 3444
Helixi349 – 36315
Helixi374 – 3796
Turni380 – 3823
Beta strandi397 – 4048
Helixi408 – 4158
Turni420 – 4223
Beta strandi431 – 4333
Turni435 – 4373
Beta strandi440 – 4423
Helixi448 – 46821
Helixi473 – 49018
Helixi493 – 4986
Helixi507 – 53226
Beta strandi535 – 5406
Beta strandi543 – 5475
Helixi553 – 56715
Helixi568 – 5703
Beta strandi578 – 59013
Beta strandi593 – 5975
Beta strandi604 – 6074
Helixi609 – 6113
Helixi617 – 63317
Helixi636 – 64510
Helixi657 – 6604
Beta strandi662 – 6654
Helixi670 – 6723
Helixi677 – 68711
Turni688 – 6903
Beta strandi701 – 7033
Helixi710 – 7123
Beta strandi713 – 7164
Helixi717 – 7193
Turni722 – 7243
Helixi731 – 7344
Helixi737 – 7404
Helixi742 – 7465
Turni747 – 7493
Helixi753 – 7553

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QHTX-ray2.10A1-775[»]
4K8XX-ray2.28A1-775[»]
ProteinModelPortaliQ56366.
SMRiQ56366. Positions 1-750.

Miscellaneous databases

EvolutionaryTraceiQ56366.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 2 hits.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56366-1 [UniParc]FASTAAdd to Basket

« Hide

MILDTDYITE NGKPVIRVFK KENGEFKIEY DRTFEPYFYA LLKDDSAIED    50
VKKVTAKRHG TVVKVKRAEK VQKKFLGRPI EVWKLYFNHP QDVPAIRDRI 100
RAHPAVVDIY EYDIPFAKRY LIDKGLIPME GDEELTMLAF DIETLYHEGE 150
EFGTGPILMI SYADGSEARV ITWKKIDLPY VDVVSTEKEM IKRFLRVVRE 200
KDPDVLITYN GDNFDFAYLK KRCEELGIKF TLGRDGSEPK IQRMGDRFAV 250
EVKGRIHFDL YPVIRRTINL PTYTLEAVYE AVFGKPKEKV YAEEIAQAWE 300
SGEGLERVAR YSMEDAKVTY ELGREFFPME AQLSRLIGQS LWDVSRSSTG 350
NLVEWFLLRK AYKRNELAPN KPDERELARR RGGYAGGYVK EPERGLWDNI 400
VYLDFRSLYP SIIITHNVSP DTLNREGCKE YDVAPEVGHK FCKDFPGFIP 450
SLLGDLLEER QKIKRKMKAT VDPLEKKLLD YRQRAIKILA NSFYGYYGYA 500
KARWYCKECA ESVTAWGREY IEMVIRELEE KFGFKVLYAD TDGLHATIPG 550
ADAETVKKKA KEFLKYINPK LPGLLELEYE GFYVRGFFVT KKKYAVIDEE 600
GKITTRGLEI VRRDWSEIAK ETQARVLEAI LKHGDVEEAV RIVKEVTEKL 650
SKYEVPPEKL VIHEQITRDL RDYKATGPHV AVAKRLAARG VKIRPGTVIS 700
YIVLKGSGRI GDRAIPADEF DPTKHRYDAE YYIENQVLPA VERILKAFGY 750
RKEDLRYQKT KQVGLGAWLK VKGKK 775
Length:775
Mass (Da):89,781
Last modified:November 1, 1996 - v1
Checksum:i71525D63C0C9CD9D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U47108 Genomic DNA. Translation: AAA88769.1.
PIRiS67920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U47108 Genomic DNA. Translation: AAA88769.1 .
PIRi S67920.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QHT X-ray 2.10 A 1-775 [» ]
4K8X X-ray 2.28 A 1-775 [» ]
ProteinModelPortali Q56366.
SMRi Q56366. Positions 1-750.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q56366.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProi IPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 2 hits.
[Graphical view ]
PRINTSi PR00106. DNAPOLB.
SMARTi SM00486. POLBc. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
PROSITEi PS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of thermostable DNA polymerases from hyperthermophilic marine Archaea with emphasis on Thermococcus sp. 9oN-7 and mutations affecting 3'-5' exonuclease activity."
    Southworth M.W., Kong H., Kucera R.B., Ware J., Jannasch H.W., Perler F.B.
    Proc. Natl. Acad. Sci. U.S.A. 93:5281-5285(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDPOL_THES9
AccessioniPrimary (citable) accession number: Q56366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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