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Q56366

- DPOL_THES9

UniProt

Q56366 - DPOL_THES9

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Protein

DNA polymerase

Gene

pol

Organism
Thermococcus sp. (strain 9oN-7)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase (EC:2.7.7.7)
Gene namesi
Name:pol
Synonyms:polA
OrganismiThermococcus sp. (strain 9oN-7)
Taxonomic identifieri103799 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775DNA polymerasePRO_0000046489Add
BLAST

Structurei

Secondary structure

1
775
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 109Combined sources
Beta strandi13 – 2210Combined sources
Beta strandi25 – 317Combined sources
Beta strandi37 – 437Combined sources
Helixi45 – 473Combined sources
Helixi48 – 514Combined sources
Beta strandi55 – 584Combined sources
Beta strandi61 – 644Combined sources
Beta strandi67 – 759Combined sources
Beta strandi78 – 869Combined sources
Helixi92 – 10110Combined sources
Beta strandi106 – 1116Combined sources
Helixi116 – 1238Combined sources
Beta strandi137 – 1448Combined sources
Beta strandi157 – 1637Combined sources
Beta strandi168 – 1747Combined sources
Beta strandi179 – 1835Combined sources
Helixi187 – 20115Combined sources
Beta strandi204 – 2107Combined sources
Turni211 – 2144Combined sources
Helixi215 – 22511Combined sources
Beta strandi240 – 2445Combined sources
Beta strandi247 – 2515Combined sources
Beta strandi255 – 2595Combined sources
Helixi260 – 2678Combined sources
Helixi275 – 2839Combined sources
Helixi292 – 2998Combined sources
Helixi305 – 33733Combined sources
Helixi341 – 3444Combined sources
Helixi349 – 36315Combined sources
Helixi374 – 3796Combined sources
Turni380 – 3823Combined sources
Beta strandi397 – 4048Combined sources
Helixi408 – 4158Combined sources
Turni420 – 4223Combined sources
Beta strandi431 – 4333Combined sources
Turni435 – 4373Combined sources
Beta strandi440 – 4423Combined sources
Helixi448 – 46821Combined sources
Helixi473 – 49018Combined sources
Helixi493 – 4986Combined sources
Helixi507 – 53226Combined sources
Beta strandi535 – 5406Combined sources
Beta strandi543 – 5475Combined sources
Helixi553 – 56715Combined sources
Helixi568 – 5703Combined sources
Beta strandi578 – 59013Combined sources
Beta strandi593 – 5975Combined sources
Beta strandi604 – 6074Combined sources
Helixi609 – 6113Combined sources
Helixi617 – 63317Combined sources
Helixi636 – 64510Combined sources
Helixi657 – 6604Combined sources
Beta strandi662 – 6654Combined sources
Helixi670 – 6723Combined sources
Helixi677 – 68711Combined sources
Turni688 – 6903Combined sources
Beta strandi701 – 7033Combined sources
Helixi710 – 7123Combined sources
Beta strandi713 – 7164Combined sources
Helixi717 – 7193Combined sources
Turni722 – 7243Combined sources
Helixi731 – 7344Combined sources
Helixi737 – 7404Combined sources
Helixi742 – 7465Combined sources
Turni747 – 7493Combined sources
Helixi753 – 7553Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QHTX-ray2.10A1-775[»]
4K8XX-ray2.28A1-775[»]
ProteinModelPortaliQ56366.
SMRiQ56366. Positions 1-750.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56366.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 2 hits.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56366-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILDTDYITE NGKPVIRVFK KENGEFKIEY DRTFEPYFYA LLKDDSAIED
60 70 80 90 100
VKKVTAKRHG TVVKVKRAEK VQKKFLGRPI EVWKLYFNHP QDVPAIRDRI
110 120 130 140 150
RAHPAVVDIY EYDIPFAKRY LIDKGLIPME GDEELTMLAF DIETLYHEGE
160 170 180 190 200
EFGTGPILMI SYADGSEARV ITWKKIDLPY VDVVSTEKEM IKRFLRVVRE
210 220 230 240 250
KDPDVLITYN GDNFDFAYLK KRCEELGIKF TLGRDGSEPK IQRMGDRFAV
260 270 280 290 300
EVKGRIHFDL YPVIRRTINL PTYTLEAVYE AVFGKPKEKV YAEEIAQAWE
310 320 330 340 350
SGEGLERVAR YSMEDAKVTY ELGREFFPME AQLSRLIGQS LWDVSRSSTG
360 370 380 390 400
NLVEWFLLRK AYKRNELAPN KPDERELARR RGGYAGGYVK EPERGLWDNI
410 420 430 440 450
VYLDFRSLYP SIIITHNVSP DTLNREGCKE YDVAPEVGHK FCKDFPGFIP
460 470 480 490 500
SLLGDLLEER QKIKRKMKAT VDPLEKKLLD YRQRAIKILA NSFYGYYGYA
510 520 530 540 550
KARWYCKECA ESVTAWGREY IEMVIRELEE KFGFKVLYAD TDGLHATIPG
560 570 580 590 600
ADAETVKKKA KEFLKYINPK LPGLLELEYE GFYVRGFFVT KKKYAVIDEE
610 620 630 640 650
GKITTRGLEI VRRDWSEIAK ETQARVLEAI LKHGDVEEAV RIVKEVTEKL
660 670 680 690 700
SKYEVPPEKL VIHEQITRDL RDYKATGPHV AVAKRLAARG VKIRPGTVIS
710 720 730 740 750
YIVLKGSGRI GDRAIPADEF DPTKHRYDAE YYIENQVLPA VERILKAFGY
760 770
RKEDLRYQKT KQVGLGAWLK VKGKK
Length:775
Mass (Da):89,781
Last modified:November 1, 1996 - v1
Checksum:i71525D63C0C9CD9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47108 Genomic DNA. Translation: AAA88769.1.
PIRiS67920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47108 Genomic DNA. Translation: AAA88769.1 .
PIRi S67920.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QHT X-ray 2.10 A 1-775 [» ]
4K8X X-ray 2.28 A 1-775 [» ]
ProteinModelPortali Q56366.
SMRi Q56366. Positions 1-750.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q56366.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProi IPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 2 hits.
[Graphical view ]
PRINTSi PR00106. DNAPOLB.
SMARTi SM00486. POLBc. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
PROSITEi PS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of thermostable DNA polymerases from hyperthermophilic marine Archaea with emphasis on Thermococcus sp. 9oN-7 and mutations affecting 3'-5' exonuclease activity."
    Southworth M.W., Kong H., Kucera R.B., Ware J., Jannasch H.W., Perler F.B.
    Proc. Natl. Acad. Sci. U.S.A. 93:5281-5285(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDPOL_THES9
AccessioniPrimary (citable) accession number: Q56366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3