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Protein

DNA polymerase

Gene

pol

Organism
Thermococcus sp. (strain 9oN-7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase (EC:2.7.7.7)
Gene namesi
Name:pol
Synonyms:polA
OrganismiThermococcus sp. (strain 9oN-7)
Taxonomic identifieri103799 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000464891 – 775DNA polymeraseAdd BLAST775

Structurei

Secondary structure

1775
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 10Combined sources9
Beta strandi13 – 22Combined sources10
Beta strandi25 – 31Combined sources7
Beta strandi37 – 43Combined sources7
Helixi45 – 47Combined sources3
Helixi48 – 51Combined sources4
Beta strandi55 – 58Combined sources4
Beta strandi61 – 64Combined sources4
Beta strandi67 – 75Combined sources9
Beta strandi78 – 86Combined sources9
Helixi92 – 101Combined sources10
Beta strandi106 – 111Combined sources6
Helixi116 – 123Combined sources8
Beta strandi137 – 144Combined sources8
Beta strandi157 – 163Combined sources7
Beta strandi168 – 174Combined sources7
Beta strandi179 – 183Combined sources5
Helixi187 – 201Combined sources15
Beta strandi204 – 210Combined sources7
Turni211 – 214Combined sources4
Helixi215 – 225Combined sources11
Beta strandi240 – 244Combined sources5
Beta strandi247 – 251Combined sources5
Beta strandi255 – 259Combined sources5
Helixi260 – 267Combined sources8
Helixi275 – 283Combined sources9
Helixi292 – 299Combined sources8
Helixi305 – 337Combined sources33
Helixi341 – 344Combined sources4
Helixi349 – 363Combined sources15
Helixi374 – 379Combined sources6
Turni380 – 382Combined sources3
Beta strandi397 – 404Combined sources8
Helixi408 – 415Combined sources8
Turni420 – 422Combined sources3
Beta strandi431 – 433Combined sources3
Turni435 – 437Combined sources3
Beta strandi440 – 442Combined sources3
Helixi448 – 468Combined sources21
Helixi473 – 490Combined sources18
Helixi493 – 498Combined sources6
Helixi507 – 532Combined sources26
Beta strandi535 – 540Combined sources6
Beta strandi543 – 547Combined sources5
Helixi553 – 567Combined sources15
Helixi568 – 570Combined sources3
Beta strandi578 – 590Combined sources13
Beta strandi593 – 597Combined sources5
Beta strandi604 – 607Combined sources4
Helixi609 – 611Combined sources3
Helixi617 – 633Combined sources17
Helixi636 – 645Combined sources10
Helixi657 – 660Combined sources4
Beta strandi662 – 665Combined sources4
Helixi670 – 672Combined sources3
Helixi677 – 687Combined sources11
Turni688 – 690Combined sources3
Beta strandi701 – 703Combined sources3
Helixi710 – 712Combined sources3
Beta strandi713 – 716Combined sources4
Helixi717 – 719Combined sources3
Turni722 – 724Combined sources3
Helixi731 – 734Combined sources4
Helixi737 – 740Combined sources4
Helixi742 – 746Combined sources5
Turni747 – 749Combined sources3
Helixi753 – 755Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QHTX-ray2.10A1-775[»]
4K8XX-ray2.28A1-775[»]
ProteinModelPortaliQ56366.
SMRiQ56366.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56366.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 2 hits.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILDTDYITE NGKPVIRVFK KENGEFKIEY DRTFEPYFYA LLKDDSAIED
60 70 80 90 100
VKKVTAKRHG TVVKVKRAEK VQKKFLGRPI EVWKLYFNHP QDVPAIRDRI
110 120 130 140 150
RAHPAVVDIY EYDIPFAKRY LIDKGLIPME GDEELTMLAF DIETLYHEGE
160 170 180 190 200
EFGTGPILMI SYADGSEARV ITWKKIDLPY VDVVSTEKEM IKRFLRVVRE
210 220 230 240 250
KDPDVLITYN GDNFDFAYLK KRCEELGIKF TLGRDGSEPK IQRMGDRFAV
260 270 280 290 300
EVKGRIHFDL YPVIRRTINL PTYTLEAVYE AVFGKPKEKV YAEEIAQAWE
310 320 330 340 350
SGEGLERVAR YSMEDAKVTY ELGREFFPME AQLSRLIGQS LWDVSRSSTG
360 370 380 390 400
NLVEWFLLRK AYKRNELAPN KPDERELARR RGGYAGGYVK EPERGLWDNI
410 420 430 440 450
VYLDFRSLYP SIIITHNVSP DTLNREGCKE YDVAPEVGHK FCKDFPGFIP
460 470 480 490 500
SLLGDLLEER QKIKRKMKAT VDPLEKKLLD YRQRAIKILA NSFYGYYGYA
510 520 530 540 550
KARWYCKECA ESVTAWGREY IEMVIRELEE KFGFKVLYAD TDGLHATIPG
560 570 580 590 600
ADAETVKKKA KEFLKYINPK LPGLLELEYE GFYVRGFFVT KKKYAVIDEE
610 620 630 640 650
GKITTRGLEI VRRDWSEIAK ETQARVLEAI LKHGDVEEAV RIVKEVTEKL
660 670 680 690 700
SKYEVPPEKL VIHEQITRDL RDYKATGPHV AVAKRLAARG VKIRPGTVIS
710 720 730 740 750
YIVLKGSGRI GDRAIPADEF DPTKHRYDAE YYIENQVLPA VERILKAFGY
760 770
RKEDLRYQKT KQVGLGAWLK VKGKK
Length:775
Mass (Da):89,781
Last modified:November 1, 1996 - v1
Checksum:i71525D63C0C9CD9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47108 Genomic DNA. Translation: AAA88769.1.
PIRiS67920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47108 Genomic DNA. Translation: AAA88769.1.
PIRiS67920.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QHTX-ray2.10A1-775[»]
4K8XX-ray2.28A1-775[»]
ProteinModelPortaliQ56366.
SMRiQ56366.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ56366.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 2 hits.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPOL_THES9
AccessioniPrimary (citable) accession number: Q56366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.