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Protein

ABC transporter riboflavin-binding protein RfuA

Gene

rfuA

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Binds riboflavin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124RiboflavinCombined sources1 Publication1
Binding sitei140RiboflavinCombined sources1 Publication1
Binding sitei176RiboflavinCombined sources1 Publication1
Binding sitei208RiboflavinCombined sources1 Publication1
Binding sitei255RiboflavinCombined sources1 Publication1

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter riboflavin-binding protein RfuACurated
Alternative name(s):
Membrane lipoprotein TpN38(b)Curated
Gene namesi
Name:rfuA1 Publication
Synonyms:tpn381 Publication
Ordered Locus Names:TP_0298
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane 1 Publication; Lipid-anchor 1 Publication; Periplasmic side 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001800820 – 343ABC transporter riboflavin-binding protein RfuAAdd BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi20N-palmitoyl cysteine1 Publication1
Lipidationi20S-diacylglycerol cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Subunit structurei

Monomer in solution (PubMed:23404400). The complex is probably composed of two ATP-binding proteins (RfuB), two transmembrane proteins (RfuC and RfuD) and a solute-binding protein (RfuA) (Probable).1 Publication1 Publication

Protein-protein interaction databases

IntActiQ56328, 9 interactors
STRINGi243276.TP0298

Structurei

Secondary structure

1343
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 38Combined sources9
Helixi44 – 61Combined sources18
Turni62 – 64Combined sources3
Beta strandi67 – 73Combined sources7
Helixi78 – 80Combined sources3
Helixi81 – 90Combined sources10
Beta strandi95 – 101Combined sources7
Helixi104 – 114Combined sources11
Beta strandi120 – 124Combined sources5
Beta strandi131 – 138Combined sources8
Helixi140 – 156Combined sources17
Beta strandi167 – 174Combined sources8
Helixi177 – 181Combined sources5
Helixi183 – 194Combined sources12
Beta strandi199 – 204Combined sources6
Beta strandi206 – 209Combined sources4
Helixi211 – 224Combined sources14
Beta strandi228 – 232Combined sources5
Helixi234 – 236Combined sources3
Helixi237 – 247Combined sources11
Beta strandi250 – 256Combined sources7
Helixi259 – 261Combined sources3
Turni263 – 265Combined sources3
Beta strandi266 – 272Combined sources7
Helixi274 – 286Combined sources13
Beta strandi294 – 298Combined sources5
Helixi300 – 302Combined sources3
Beta strandi304 – 307Combined sources4
Helixi312 – 317Combined sources6
Helixi320 – 335Combined sources16
Beta strandi336 – 338Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IILX-ray1.30A21-343[»]
ProteinModelPortaliQ56328
SMRiQ56328
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 46Riboflavin bindingCombined sources1 Publication4

Sequence similaritiesi

Belongs to the BMP lipoprotein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108SSC Bacteria
COG1744 LUCA
KOiK02058
OMAiRYNQREQ

Family and domain databases

InterProiView protein in InterPro
IPR028082 Peripla_BP_I
IPR003760 PnrA-like
PfamiView protein in Pfam
PF02608 Bmp, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGAVCVLSA LIAVFTCFSC RPAVQDERAV RIAVFVPGFR HDSPVYAMLC
60 70 80 90 100
DGVERAVTQE RATGRSIGLD IIEAGPNQAL WREKLAHLAA EQRYRLIVSS
110 120 130 140 150
NPALPHVLEP ILRQFPLQRF LVLDAYAPQE HSLITFRYNQ WEQAYLAGHL
160 170 180 190 200
SALVSASAMR FANADKKIGL IAGQSYPVMT QTIIPAFLAG ARAVDPAFEV
210 220 230 240 250
DVRVVGNWYD AAKSADLARI LFHEGVDVMM PICGGANQGV LAAARELGFY
260 270 280 290 300
VSWFDDNGYA RAPGYVVGSS VMEQERLAYE QTLRCIRGEL PSAGAWTLGV
310 320 330 340
KDGYVRFIEE DPLYLQTVPE PIRVRQSALL RRIQSGELTL PVR
Length:343
Mass (Da):37,882
Last modified:November 1, 1996 - v1
Checksum:i800687C5A1420C4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12861 Genomic DNA Translation: AAB02167.1
AE000520 Genomic DNA Translation: AAC65287.1
PIRiD71341
RefSeqiWP_010881747.1, NC_021490.2

Genome annotation databases

EnsemblBacteriaiAAC65287; AAC65287; TP_0298
GeneIDi34331548
KEGGitpa:TP_0298

Similar proteinsi

Entry informationi

Entry nameiRFUA_TREPA
AccessioniPrimary (citable) accession number: Q56328
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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