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Q56320

- TRPF_THEMA

UniProt

Q56320 - TRPF_THEMA

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Protein
N-(5'-phosphoribosyl)anthranilate isomerase
Gene
trpF, TM_0139
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-301.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpF
Ordered Locus Names:TM_0139
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation
PRO_0000154390Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi243274.TM0139.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64
Helixi12 – 2110
Beta strandi24 – 296
Helixi40 – 4910
Beta strandi52 – 6211
Helixi65 – 7511
Beta strandi78 – 825
Helixi88 – 958
Beta strandi98 – 10811
Helixi109 – 1157
Helixi116 – 1183
Beta strandi123 – 1286
Beta strandi130 – 1345
Helixi141 – 1433
Helixi145 – 1506
Beta strandi154 – 1596
Turni162 – 1643
Helixi165 – 1728
Beta strandi175 – 1806
Helixi181 – 1833
Beta strandi184 – 1863
Helixi192 – 20312

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DL3X-ray2.70A/B1-205[»]
1LBMX-ray2.80A1-205[»]
1NSJX-ray2.00A1-205[»]
ProteinModelPortaliQ56320.
SMRiQ56320. Positions 1-205.

Miscellaneous databases

EvolutionaryTraceiQ56320.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.

Phylogenomic databases

eggNOGiCOG0135.
KOiK01817.
OMAiDILQLHG.
OrthoDBiEOG6N94DF.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q56320-1 [UniParc]FASTAAdd to Basket

« Hide

MVRVKICGIT NLEDALFSVE SGADAVGFVF YPKSKRYISP EDARRISVEL    50
PPFVFRVGVF VNEEPEKILD VASYVQLNAV QLHGEEPIEL CRKIAERILV 100
IKAVGVSNER DMERALNYRE FPILLDTKTP EYGGSGKTFD WSLILPYRDR 150
FRYLVLSGGL NPENVRSAID VVRPFAVDVS SGVEAFPGKK DHDSIKMFIK 200
NAKGL 205
Length:205
Mass (Da):23,041
Last modified:November 1, 1996 - v1
Checksum:i9E1D76948C7EAE5E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92729 Genomic DNA. Translation: CAA63390.1.
AE000512 Genomic DNA. Translation: AAD35232.1.
PIRiS59048.
RefSeqiNP_227954.1. NC_000853.1.
YP_007976488.1. NC_021214.1.
YP_008990885.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35232; AAD35232; TM_0139.
GeneIDi896969.
KEGGitma:TM0139.
tmi:THEMA_04110.
tmm:Tmari_0137.
PATRICi23935120. VBITheMar51294_0138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92729 Genomic DNA. Translation: CAA63390.1 .
AE000512 Genomic DNA. Translation: AAD35232.1 .
PIRi S59048.
RefSeqi NP_227954.1. NC_000853.1.
YP_007976488.1. NC_021214.1.
YP_008990885.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DL3 X-ray 2.70 A/B 1-205 [» ]
1LBM X-ray 2.80 A 1-205 [» ]
1NSJ X-ray 2.00 A 1-205 [» ]
ProteinModelPortali Q56320.
SMRi Q56320. Positions 1-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM0139.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35232 ; AAD35232 ; TM_0139 .
GeneIDi 896969.
KEGGi tma:TM0139.
tmi:THEMA_04110.
tmm:Tmari_0137.
PATRICi 23935120. VBITheMar51294_0138.

Phylogenomic databases

eggNOGi COG0135.
KOi K01817.
OMAi DILQLHG.
OrthoDBi EOG6N94DF.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
BioCyci MetaCyc:MONOMER-301.

Miscellaneous databases

EvolutionaryTracei Q56320.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "(Beta alpha)8-barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritima."
    Sterner R., Dahm A., Darimont B., Ivens A., Liebl W., Kirschner K.
    EMBO J. 14:4395-4402(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  3. "Crystal structure at 2.0-A resolution of phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga maritima: possible determinants of protein stability."
    Hennig M., Sterner R., Kirschner K., Jansonius J.N.
    Biochemistry 36:6009-6016(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiTRPF_THEMA
AccessioniPrimary (citable) accession number: Q56320
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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