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Q56320

- TRPF_THEMA

UniProt

Q56320 - TRPF_THEMA

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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-301.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpF
Ordered Locus Names:TM_0139
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154390Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi243274.TM0139.

Structurei

Secondary structure

1
205
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64
Helixi12 – 2110
Beta strandi24 – 296
Helixi40 – 4910
Beta strandi52 – 6211
Helixi65 – 7511
Beta strandi78 – 825
Helixi88 – 958
Beta strandi98 – 10811
Helixi109 – 1157
Helixi116 – 1183
Beta strandi123 – 1286
Beta strandi130 – 1345
Helixi141 – 1433
Helixi145 – 1506
Beta strandi154 – 1596
Turni162 – 1643
Helixi165 – 1728
Beta strandi175 – 1806
Helixi181 – 1833
Beta strandi184 – 1863
Helixi192 – 20312

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DL3X-ray2.70A/B1-205[»]
1LBMX-ray2.80A1-205[»]
1NSJX-ray2.00A1-205[»]
ProteinModelPortaliQ56320.
SMRiQ56320. Positions 1-205.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56320.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiCOG0135.
InParanoidiQ56320.
KOiK01817.
OMAiDILQLHG.
OrthoDBiEOG6N94DF.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q56320-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRVKICGIT NLEDALFSVE SGADAVGFVF YPKSKRYISP EDARRISVEL
60 70 80 90 100
PPFVFRVGVF VNEEPEKILD VASYVQLNAV QLHGEEPIEL CRKIAERILV
110 120 130 140 150
IKAVGVSNER DMERALNYRE FPILLDTKTP EYGGSGKTFD WSLILPYRDR
160 170 180 190 200
FRYLVLSGGL NPENVRSAID VVRPFAVDVS SGVEAFPGKK DHDSIKMFIK

NAKGL
Length:205
Mass (Da):23,041
Last modified:November 1, 1996 - v1
Checksum:i9E1D76948C7EAE5E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92729 Genomic DNA. Translation: CAA63390.1.
AE000512 Genomic DNA. Translation: AAD35232.1.
PIRiS59048.
RefSeqiNP_227954.1. NC_000853.1.
YP_007976488.1. NC_021214.1.
YP_008990885.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35232; AAD35232; TM_0139.
GeneIDi18092672.
896969.
KEGGitma:TM0139.
tmi:THEMA_04110.
tmm:Tmari_0137.
PATRICi23935120. VBITheMar51294_0138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92729 Genomic DNA. Translation: CAA63390.1 .
AE000512 Genomic DNA. Translation: AAD35232.1 .
PIRi S59048.
RefSeqi NP_227954.1. NC_000853.1.
YP_007976488.1. NC_021214.1.
YP_008990885.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DL3 X-ray 2.70 A/B 1-205 [» ]
1LBM X-ray 2.80 A 1-205 [» ]
1NSJ X-ray 2.00 A 1-205 [» ]
ProteinModelPortali Q56320.
SMRi Q56320. Positions 1-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM0139.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35232 ; AAD35232 ; TM_0139 .
GeneIDi 18092672.
896969.
KEGGi tma:TM0139.
tmi:THEMA_04110.
tmm:Tmari_0137.
PATRICi 23935120. VBITheMar51294_0138.

Phylogenomic databases

eggNOGi COG0135.
InParanoidi Q56320.
KOi K01817.
OMAi DILQLHG.
OrthoDBi EOG6N94DF.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
BioCyci MetaCyc:MONOMER-301.

Miscellaneous databases

EvolutionaryTracei Q56320.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "(Beta alpha)8-barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritima."
    Sterner R., Dahm A., Darimont B., Ivens A., Liebl W., Kirschner K.
    EMBO J. 14:4395-4402(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  3. "Crystal structure at 2.0-A resolution of phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga maritima: possible determinants of protein stability."
    Hennig M., Sterner R., Kirschner K., Jansonius J.N.
    Biochemistry 36:6009-6016(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiTRPF_THEMA
AccessioniPrimary (citable) accession number: Q56320
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3