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Q56320

- TRPF_THEMA

UniProt

Q56320 - TRPF_THEMA

Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-301.
    UniPathwayiUPA00035; UER00042.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:trpF
    Ordered Locus Names:TM_0139
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154390Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi243274.TM0139.

    Structurei

    Secondary structure

    1
    205
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 64
    Helixi12 – 2110
    Beta strandi24 – 296
    Helixi40 – 4910
    Beta strandi52 – 6211
    Helixi65 – 7511
    Beta strandi78 – 825
    Helixi88 – 958
    Beta strandi98 – 10811
    Helixi109 – 1157
    Helixi116 – 1183
    Beta strandi123 – 1286
    Beta strandi130 – 1345
    Helixi141 – 1433
    Helixi145 – 1506
    Beta strandi154 – 1596
    Turni162 – 1643
    Helixi165 – 1728
    Beta strandi175 – 1806
    Helixi181 – 1833
    Beta strandi184 – 1863
    Helixi192 – 20312

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1DL3X-ray2.70A/B1-205[»]
    1LBMX-ray2.80A1-205[»]
    1NSJX-ray2.00A1-205[»]
    ProteinModelPortaliQ56320.
    SMRiQ56320. Positions 1-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ56320.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpF family.Curated

    Phylogenomic databases

    eggNOGiCOG0135.
    KOiK01817.
    OMAiDILQLHG.
    OrthoDBiEOG6N94DF.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q56320-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRVKICGIT NLEDALFSVE SGADAVGFVF YPKSKRYISP EDARRISVEL    50
    PPFVFRVGVF VNEEPEKILD VASYVQLNAV QLHGEEPIEL CRKIAERILV 100
    IKAVGVSNER DMERALNYRE FPILLDTKTP EYGGSGKTFD WSLILPYRDR 150
    FRYLVLSGGL NPENVRSAID VVRPFAVDVS SGVEAFPGKK DHDSIKMFIK 200
    NAKGL 205
    Length:205
    Mass (Da):23,041
    Last modified:November 1, 1996 - v1
    Checksum:i9E1D76948C7EAE5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92729 Genomic DNA. Translation: CAA63390.1.
    AE000512 Genomic DNA. Translation: AAD35232.1.
    PIRiS59048.
    RefSeqiNP_227954.1. NC_000853.1.
    YP_007976488.1. NC_021214.1.
    YP_008990885.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD35232; AAD35232; TM_0139.
    GeneIDi896969.
    KEGGitma:TM0139.
    tmi:THEMA_04110.
    tmm:Tmari_0137.
    PATRICi23935120. VBITheMar51294_0138.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92729 Genomic DNA. Translation: CAA63390.1 .
    AE000512 Genomic DNA. Translation: AAD35232.1 .
    PIRi S59048.
    RefSeqi NP_227954.1. NC_000853.1.
    YP_007976488.1. NC_021214.1.
    YP_008990885.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1DL3 X-ray 2.70 A/B 1-205 [» ]
    1LBM X-ray 2.80 A 1-205 [» ]
    1NSJ X-ray 2.00 A 1-205 [» ]
    ProteinModelPortali Q56320.
    SMRi Q56320. Positions 1-205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM0139.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD35232 ; AAD35232 ; TM_0139 .
    GeneIDi 896969.
    KEGGi tma:TM0139.
    tmi:THEMA_04110.
    tmm:Tmari_0137.
    PATRICi 23935120. VBITheMar51294_0138.

    Phylogenomic databases

    eggNOGi COG0135.
    KOi K01817.
    OMAi DILQLHG.
    OrthoDBi EOG6N94DF.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .
    BioCyci MetaCyc:MONOMER-301.

    Miscellaneous databases

    EvolutionaryTracei Q56320.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "(Beta alpha)8-barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritima."
      Sterner R., Dahm A., Darimont B., Ivens A., Liebl W., Kirschner K.
      EMBO J. 14:4395-4402(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
    3. "Crystal structure at 2.0-A resolution of phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga maritima: possible determinants of protein stability."
      Hennig M., Sterner R., Kirschner K., Jansonius J.N.
      Biochemistry 36:6009-6016(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

    Entry informationi

    Entry nameiTRPF_THEMA
    AccessioniPrimary (citable) accession number: Q56320
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3