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Protein

Indole-3-glycerol phosphate synthase

Gene

trpC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Bifunctional protein TrpGD (trpGD), Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD), Bifunctional protein TrpGD (trpGD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF), N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC), Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 2 (trpB2), Tryptophan synthase beta chain 1 (trpB1), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-343.
BRENDAi4.1.1.48. 6331.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
Gene namesi
Name:trpC
Ordered Locus Names:TM_0140
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Indole-3-glycerol phosphate synthasePRO_0000154266Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0140.

Structurei

Secondary structure

1
252
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1411Combined sources
Helixi15 – 173Combined sources
Helixi20 – 223Combined sources
Helixi31 – 366Combined sources
Beta strandi39 – 413Combined sources
Beta strandi43 – 486Combined sources
Beta strandi53 – 553Combined sources
Helixi64 – 7411Combined sources
Beta strandi76 – 816Combined sources
Beta strandi85 – 873Combined sources
Helixi92 – 987Combined sources
Beta strandi105 – 1084Combined sources
Helixi115 – 1228Combined sources
Beta strandi126 – 1316Combined sources
Helixi132 – 1343Combined sources
Helixi137 – 14812Combined sources
Turni149 – 1513Combined sources
Beta strandi153 – 1586Combined sources
Helixi161 – 1688Combined sources
Beta strandi174 – 1796Combined sources
Turni183 – 1853Combined sources
Helixi192 – 1965Combined sources
Helixi197 – 1993Combined sources
Beta strandi204 – 2107Combined sources
Helixi215 – 2173Combined sources
Helixi218 – 2214Combined sources
Turni222 – 2243Combined sources
Beta strandi226 – 2305Combined sources
Helixi232 – 2365Combined sources
Beta strandi237 – 2393Combined sources
Helixi240 – 25011Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I4NX-ray2.50A/B2-252[»]
1J5TX-ray3.00A24-252[»]
ProteinModelPortaliQ56319.
SMRiQ56319. Positions 2-252.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56319.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpC family.Curated

Phylogenomic databases

eggNOGiENOG4105DK0. Bacteria.
COG0134. LUCA.
InParanoidiQ56319.
KOiK01609.
OMAiGISYITD.
OrthoDBiEOG6WT8JX.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_B. IGPS_B.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLWEIVEA KKKDILEIDG ENLIVQRRNH RFLEVLSGKE RVKIIAEFKK
60 70 80 90 100
ASPSAGDINA DASLEDFIRM YDELADAISI LTEKHYFKGD PAFVRAARNL
110 120 130 140 150
TCRPILAKDF YIDTVQVKLA SSVGADAILI IARILTAEQI KEIYEAAEEL
160 170 180 190 200
GMDSLVEVHS REDLEKVFSV IRPKIIGINT RDLDTFEIKK NVLWELLPLV
210 220 230 240 250
PDDTVVVAES GIKDPRELKD LRGKVNAVLV GTSIMKAENP RRFLEEMRAW

SE
Length:252
Mass (Da):28,660
Last modified:May 30, 2000 - v3
Checksum:iAA60B8E28BC043DF
GO

Sequence cautioni

The sequence AAD35233.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 2261N → K in CAA63389 (PubMed:7556082).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92729 Genomic DNA. Translation: CAA63389.1.
AE000512 Genomic DNA. Translation: AAD35233.1. Different initiation.
PIRiS59047.
RefSeqiNP_227955.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD35233; AAD35233; TM_0140.
GeneIDi896970.
KEGGitma:TM0140.
PATRICi23935122. VBITheMar51294_0139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92729 Genomic DNA. Translation: CAA63389.1.
AE000512 Genomic DNA. Translation: AAD35233.1. Different initiation.
PIRiS59047.
RefSeqiNP_227955.1. NC_000853.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I4NX-ray2.50A/B2-252[»]
1J5TX-ray3.00A24-252[»]
ProteinModelPortaliQ56319.
SMRiQ56319. Positions 2-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35233; AAD35233; TM_0140.
GeneIDi896970.
KEGGitma:TM0140.
PATRICi23935122. VBITheMar51294_0139.

Phylogenomic databases

eggNOGiENOG4105DK0. Bacteria.
COG0134. LUCA.
InParanoidiQ56319.
KOiK01609.
OMAiGISYITD.
OrthoDBiEOG6WT8JX.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00043.
BioCyciMetaCyc:MONOMER-343.
BRENDAi4.1.1.48. 6331.

Miscellaneous databases

EvolutionaryTraceiQ56319.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_B. IGPS_B.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "(Beta alpha)8-barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritima."
    Sterner R., Dahm A., Darimont B., Ivens A., Liebl W., Kirschner K.
    EMBO J. 14:4395-4402(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiTRPC_THEMA
AccessioniPrimary (citable) accession number: Q56319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: April 13, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.