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Q56319 (TRPC_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48
Gene names
Name:trpC
Ordered Locus Names:TM_0140
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga ›

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00134_B

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP-Rule MF_00134_B

Sequence similarities

Belongs to the TrpC family.

Sequence caution

The sequence AAD35233.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00134_B
PRO_0000154266

Experimental info

Sequence conflict2261N → K in CAA63389. Ref.1

Secondary structure

1 ....................................................... 252
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q56319 [UniParc].

Last modified May 30, 2000. Version 3.
Checksum: AA60B8E28BC043DF

FASTA25228,660
        10         20         30         40         50         60 
MRRLWEIVEA KKKDILEIDG ENLIVQRRNH RFLEVLSGKE RVKIIAEFKK ASPSAGDINA 

        70         80         90        100        110        120 
DASLEDFIRM YDELADAISI LTEKHYFKGD PAFVRAARNL TCRPILAKDF YIDTVQVKLA 

       130        140        150        160        170        180 
SSVGADAILI IARILTAEQI KEIYEAAEEL GMDSLVEVHS REDLEKVFSV IRPKIIGINT 

       190        200        210        220        230        240 
RDLDTFEIKK NVLWELLPLV PDDTVVVAES GIKDPRELKD LRGKVNAVLV GTSIMKAENP 

       250 
RRFLEEMRAW SE

« Hide

References

« Hide 'large scale' references
[1]"(Beta alpha)8-barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritima."
Sterner R., Dahm A., Darimont B., Ivens A., Liebl W., Kirschner K.
EMBO J. 14:4395-4402(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
[2]"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima."
Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. expand/collapse author list , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.
Nature 399:323-329(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X92729 Genomic DNA. Translation: CAA63389.1.
AE000512 Genomic DNA. Translation: AAD35233.1. Different initiation.
PIRS59047.
RefSeqNP_227955.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1I4NX-ray2.50A/B2-252[»]
1J5TX-ray3.00A24-252[»]
ProteinModelPortalQ56319.
SMRQ56319. Positions 2-252.
ModBaseSearch...

Protein-protein interaction databases

STRING243274.TM0140.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD35233; AAD35233; TM_0140.
GeneID896970.
KEGGtma:TM0140.
PATRIC23935122. VBITheMar51294_0139.

Phylogenomic databases

eggNOGCOG0134.
KOK01609.
OMAGISYITD.
ProtClustDBCLSK794946.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-343.
UniPathwayUPA00035; UER00043.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00134_B. IGPS_B.
InterProIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
PROSITEPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ56319.

Entry information

Entry nameTRPC_THEMA
AccessionPrimary (citable) accession number: Q56319
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: May 1, 2013
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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