Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Indole-3-glycerol phosphate synthase

Gene

trpC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Bifunctional protein TrpGD (trpGD), Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD), Bifunctional protein TrpGD (trpGD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF), N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC), Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 2 (trpB2), Tryptophan synthase beta chain 1 (trpB1), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-343.
BRENDAi4.1.1.48. 6331.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
Gene namesi
Name:trpC
Ordered Locus Names:TM_0140
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001542661 – 252Indole-3-glycerol phosphate synthaseAdd BLAST252

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0140.

Structurei

Secondary structure

1252
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 14Combined sources11
Helixi15 – 17Combined sources3
Helixi20 – 22Combined sources3
Helixi31 – 36Combined sources6
Beta strandi39 – 41Combined sources3
Beta strandi43 – 48Combined sources6
Beta strandi53 – 55Combined sources3
Helixi64 – 74Combined sources11
Beta strandi76 – 81Combined sources6
Beta strandi85 – 87Combined sources3
Helixi92 – 98Combined sources7
Beta strandi105 – 108Combined sources4
Helixi115 – 122Combined sources8
Beta strandi126 – 131Combined sources6
Helixi132 – 134Combined sources3
Helixi137 – 148Combined sources12
Turni149 – 151Combined sources3
Beta strandi153 – 158Combined sources6
Helixi161 – 168Combined sources8
Beta strandi174 – 179Combined sources6
Turni183 – 185Combined sources3
Helixi192 – 196Combined sources5
Helixi197 – 199Combined sources3
Beta strandi204 – 210Combined sources7
Helixi215 – 217Combined sources3
Helixi218 – 221Combined sources4
Turni222 – 224Combined sources3
Beta strandi226 – 230Combined sources5
Helixi232 – 236Combined sources5
Beta strandi237 – 239Combined sources3
Helixi240 – 250Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I4NX-ray2.50A/B2-252[»]
1J5TX-ray3.00A24-252[»]
ProteinModelPortaliQ56319.
SMRiQ56319.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56319.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpC family.Curated

Phylogenomic databases

eggNOGiENOG4105DK0. Bacteria.
COG0134. LUCA.
InParanoidiQ56319.
KOiK01609.
OMAiGISYITD.

Family and domain databases

CDDicd00331. IGPS. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_B. IGPS_B. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLWEIVEA KKKDILEIDG ENLIVQRRNH RFLEVLSGKE RVKIIAEFKK
60 70 80 90 100
ASPSAGDINA DASLEDFIRM YDELADAISI LTEKHYFKGD PAFVRAARNL
110 120 130 140 150
TCRPILAKDF YIDTVQVKLA SSVGADAILI IARILTAEQI KEIYEAAEEL
160 170 180 190 200
GMDSLVEVHS REDLEKVFSV IRPKIIGINT RDLDTFEIKK NVLWELLPLV
210 220 230 240 250
PDDTVVVAES GIKDPRELKD LRGKVNAVLV GTSIMKAENP RRFLEEMRAW

SE
Length:252
Mass (Da):28,660
Last modified:May 30, 2000 - v3
Checksum:iAA60B8E28BC043DF
GO

Sequence cautioni

The sequence AAD35233 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226N → K in CAA63389 (PubMed:7556082).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92729 Genomic DNA. Translation: CAA63389.1.
AE000512 Genomic DNA. Translation: AAD35233.1. Different initiation.
PIRiS59047.
RefSeqiNP_227955.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD35233; AAD35233; TM_0140.
GeneIDi896970.
KEGGitma:TM0140.
PATRICi23935122. VBITheMar51294_0139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92729 Genomic DNA. Translation: CAA63389.1.
AE000512 Genomic DNA. Translation: AAD35233.1. Different initiation.
PIRiS59047.
RefSeqiNP_227955.1. NC_000853.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I4NX-ray2.50A/B2-252[»]
1J5TX-ray3.00A24-252[»]
ProteinModelPortaliQ56319.
SMRiQ56319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35233; AAD35233; TM_0140.
GeneIDi896970.
KEGGitma:TM0140.
PATRICi23935122. VBITheMar51294_0139.

Phylogenomic databases

eggNOGiENOG4105DK0. Bacteria.
COG0134. LUCA.
InParanoidiQ56319.
KOiK01609.
OMAiGISYITD.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00043.
BioCyciMetaCyc:MONOMER-343.
BRENDAi4.1.1.48. 6331.

Miscellaneous databases

EvolutionaryTraceiQ56319.

Family and domain databases

CDDicd00331. IGPS. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_B. IGPS_B. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC_THEMA
AccessioniPrimary (citable) accession number: Q56319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.