Q56319 (TRPC_THEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	TM_0140

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.
Sequence caution	The sequence AAD35233.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 252

252

Indole-3-glycerol phosphate synthase HAMAP MF_00134_B

PRO_0000154266

Experimental info

Sequence conflict

226

1

N → K in CAA63389. Ref.1

Secondary structure

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252

Helix Strand Turn

Details...

Helix

4 – 14

11

Helix

15 – 17

3

Helix

20 – 22

3

Helix

31 – 36

6

Beta strand

39 – 41

3

Beta strand

43 – 48

6

Beta strand

53 – 55

3

Helix

64 – 74

11

Beta strand

76 – 81

6

Beta strand

85 – 87

3

Helix

92 – 98

7

Beta strand

105 – 108

4

Helix

115 – 122

8

Beta strand

126 – 131

6

Helix

132 – 134

3

Helix

137 – 148

12

Turn

149 – 151

3

Beta strand

153 – 158

6

Helix

161 – 168

8

Beta strand

174 – 179

6

Turn

183 – 185

3

Helix

192 – 196

5

Helix

197 – 199

3

Beta strand

204 – 210

7

Helix

215 – 217

3

Helix

218 – 221

4

Turn

222 – 224

3

Beta strand

226 – 230

5

Helix

232 – 236

5

Helix

240 – 250

11

Sequences

	Sequence		Length	Mass (Da)
	Q56319 [UniParc]. Last modified May 30, 2000. Version 3. Checksum: AA60B8E28BC043DF	FASTA	252	28,660
	10 20 30 40 50 60 MRRLWEIVEA KKKDILEIDG ENLIVQRRNH RFLEVLSGKE RVKIIAEFKK ASPSAGDINA 70 80 90 100 110 120 DASLEDFIRM YDELADAISI LTEKHYFKGD PAFVRAARNL TCRPILAKDF YIDTVQVKLA 130 140 150 160 170 180 SSVGADAILI IARILTAEQI KEIYEAAEEL GMDSLVEVHS REDLEKVFSV IRPKIIGINT 190 200 210 220 230 240 RDLDTFEIKK NVLWELLPLV PDDTVVVAES GIKDPRELKD LRGKVNAVLV GTSIMKAENP 250 RRFLEEMRAW SE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"(Beta alpha)8-barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritima." Sterner R., Dahm A., Darimont B., Ivens A., Liebl W., Kirschner K. EMBO J. 14:4395-4402(1995) [PubMed: 7556082] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
[2]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X92729 Genomic DNA. Translation: CAA63389.1.
AE000512 Genomic DNA. Translation: AAD35233.1. Different initiation.

PIR

S59047.

RefSeq

NP_227955.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1I4N	X-ray	2.50	A/B	2-252	[»]
1J5T	X-ray	3.00	A	24-252	[»]

ProteinModelPortal

Q56319.

SMR

Q56319. Positions 2-252.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

896970.

GenomeReviews

Gene locus TM_0140 in contig AE000512_GR.

KEGG

tma:TM0140.

NMPDR

fig|243274.1.peg.139.

PATRIC

23935122. VBITheMar51294_0139.

TIGR

TM_0140.

Phylogenomic databases

HOGENOM

HBG540956.

OMA

FETDINT.

PhylomeDB

Q56319.

ProtClustDB

CLSK794946.

Enzyme and pathway databases

BioCyc

MetaCyc:MONOMER-343.
TMAR243274:TM_0140-MONOMER.

Family and domain databases

HAMAP

MF_00134_B. IGPS_B.
[Tree]

InterPro

IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]

Gene3D

G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.

KO

K01609.

Pfam

PF00218. IGPS. 1 hit.
[Graphical view]

SUPFAM

SSF51366. RibP_bind_barrel. 1 hit.

PROSITE

PS00614. IGPS. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

TRPC_THEMA

Accession

Primary (citable) accession number: Q56319

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 30, 2000
Last modified:	January 25, 2012
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program