Reviewed, UniProtKB/Swiss-Prot Q56317 (PORB_THEMA)

Names and origin

Protein names

Recommended name:
    Pyruvate synthase subunit porB
    EC=1.2.7.1
Alternative name(s):
    Pyruvate oxidoreductase beta chain
      Short name=POR
    Pyruvic-ferredoxin oxidoreductase subunit beta

Gene names

Name:	porB
Ordered Locus Names:	TM_0018

Organism

Thermotoga maritima [Complete proteome] [HAMAP]

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyruvate synthase activity Inferred from electronic annotation. Source: EC thiamin pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 324	323	Pyruvate synthase subunit porB		PRO_0000099909

Sequences

	Sequence		Length	Mass (Da)
	Q56317-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 2425239D778A6A0E	FASTA	324	36,385
	10 20 30 40 50 60 MPVNIKQLAQ EFDKKEIGIT QGHRLCPGCG APITVKFVMM IARHLGYEPV VGLATGCLEV 70 80 90 100 110 120 STSIYPYTAW SVPYIHNAFE NVAATMSGVE TAYKALKNKG KIPEDKKYAF IAFGGDGGTY 130 140 150 160 170 180 DIGLQSLSGM LERGHKVLYV LYDNEGYMNT GNQRSGSTPP GSDTTTAPVG KKLPGKVQLK 190 200 210 220 230 240 KNIVEIVAAH ENVYAATASL SEPMDFFAKV EKALNFDGPS FLAVFSPCVR FWRVNDDKTV 250 260 270 280 290 300 EISKLAVETK YWPLYEVERG VYRVTRKPRQ FKPVEEFLKA QGRFRKLLSR PDAKEIVDEL 310 320 QEYVDRRWER LLTLEEVTKD KPIR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima." Kletzin A., Adams M.W.W. J. Bacteriol. 178:248-257(1996) [PubMed: 8550425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-17 AND 20-44. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X85171 Genomic DNA. Translation: CAA59458.1. AE000512 Genomic DNA. Translation: AAD35112.1.
PIR	D72427. B59427.
RefSeq	NP_227834.1.
3D structure databases
HSSP	HSSP built from PDB template 1KEK based on UniProtKB P94692.
ModBase	Search...
Genome annotation databases
GeneID	896832.
GenomeReviews	Gene locus TM_0018 in contig AE000512_GR.
KEGG	tma:TM0018.
NMPDR	fig|243274.1.peg.18.
TIGR	TM_0018.
Phylogenomic databases
HOGENOM	Q56317.
OMA	Q56317. YICLDNE.
Enzyme and pathway databases
BioCyc	MetaCyc:MON-424. TMAR243274:TM_0018-MON.
BRENDA	1.2.7.1. 16699.
Family and domain databases
InterPro	IPR011766. TPP_enzyme_bd_C. [Graphical view]
Pfam	PF02775. TPP_enzyme_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PORB_THEMA

Accession

Primary (citable) accession number: Q56317

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 60 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)