Q56316 (PORD_THEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvate synthase subunit porD

Alternative name(s):
Pyruvate oxidoreductase delta chain
Short name=POR
Pyruvic-ferredoxin oxidoreductase subunit delta

Gene names

Name:	porD
Ordered Locus Names:	TM_0016

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor	Binds 2 4Fe-4S clusters By similarity.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.
Sequence similarities	Contains 2 4Fe-4S ferredoxin-type domains.
Sequence caution	The sequence AAD35110.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Electron transport Transport
Domain	Repeat
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 99	98	Pyruvate synthase subunit porD		PRO_0000099924
Regions
	Domain	32 – 60	29	4Fe-4S ferredoxin-type 1
	Domain	61 – 91	31	4Fe-4S ferredoxin-type 2
Sites
	Metal binding	41	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	44	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	47	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	51	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	71	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	74	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	77	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	81	1	Iron-sulfur 1 (4Fe-4S) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q56316 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: C4253752589812F9	FASTA	99	11,257
	10 20 30 40 50 60 MSLKSWKEIP IGGVIDKPGT AREYKTGAWR VMRPILHKEK CIDCMFCWLY CPDQAIIQEG 70 80 90 GIMKGFNYDY CKGCGLCANV CPKQAIEMRP ETEFLSEEG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima." Kletzin A., Adams M.W.W. J. Bacteriol. 178:248-257(1996) [PubMed: 8550425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-21. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85171 Genomic DNA. Translation: CAA59456.1. AE000512 Genomic DNA. Translation: AAD35110.1. Different initiation.
PIR	B72427. A59427.
RefSeq	NP_227832.1. NC_000853.1.
3D structure databases
ProteinModelPortal	Q56316.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	896830.
GenomeReviews	Gene locus TM_0016 in contig AE000512_GR.
KEGG	tma:TM0016.
NMPDR	fig|243274.1.peg.16.
PATRIC	23934872. VBITheMar51294_0014.
TIGR	TM_0016.
Phylogenomic databases
HOGENOM	HBG734156.
OMA	CENCYIF.
PhylomeDB	Q56316.
ProtClustDB	CLSK874925.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-426. TMAR243274:TM_0016-MONOMER.
Family and domain databases
InterPro	IPR001450. 4Fe4S-bd_dom. IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR011898. PorD_KorD. [Graphical view]
KO	K00171.
Pfam	PF00037. Fer4. 2 hits. [Graphical view]
TIGRFAMs	TIGR02179. PorD_KorD. 1 hit.
PROSITE	PS00198. 4FE4S_FER_1. 2 hits. PS51379. 4FE4S_FER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PORD_THEMA

Accession

Primary (citable) accession number: Q56316

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program