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Reviewed, UniProtKB/Swiss-Prot Q56313 (RUVB_THEMA)

Last modified November 3, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Holliday junction ATP-dependent DNA helicase ruvB
    EC=3.6.1.-
Gene names
Name: ruvB
Ordered Locus Names: TM_1730
OrganismThermotoga maritima [Complete proteome] [HAMAP]
Taxonomic identifier2336 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

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Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing By similarity.

Subunit structure

Forms a complex with ruvA. HAMAP MF_00016

Sequence similarities

Belongs to the ruvB family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Holliday junction ATP-dependent DNA helicase ruvB HAMAP MF_00016
PRO_0000165617

Regions

Nucleotide binding58 – 658ATP Potential

Secondary structure

1 .................................................... 334
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q56313-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 6F4BBFBFA7B9C7A9

FASTA33437,156
        10         20         30         40         50         60 
MSEFLTPERT VYDSGVQFLR PKSLDEFIGQ ENVKKKLSLA LEAAKMRGEV LDHVLLAGPP 

        70         80         90        100        110        120 
GLGKTTLAHI IASELQTNIH VTSGPVLVKQ GDMAAILTSL ERGDVLFIDE IHRLNKAVEE 

       130        140        150        160        170        180 
LLYSAIEDFQ IDIMIGKGPS AKSIRIDIQP FTLVGATTRS GLLSSPLRSR FGIILELDFY 

       190        200        210        220        230        240 
TVKELKEIIK RAASLMDVEI EDAAAEMIAK RSRGTPRIAI RLTKRVRDML TVVKADRINT 

       250        260        270        280        290        300 
DIVLKTMEVL NIDDEGLDEF DRKILKTIIE IYRGGPVGLN ALAASLGVEA DTLSEVYEPY 

       310        320        330 
LLQAGFLART PRGRIVTEKA YKHLKYEVPE NRLF

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References

« Hide 'large scale' references
[1]"Cloning, sequencing, and expression of ruvB and characterization of RuvB proteins from two distantly related thermophilic eubacteria."
Tong J., Wetmur J.G.
J. Bacteriol. 178:2695-2700(1996) [PubMed: 8626340] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima."
Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. expand/collapse author list , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.
Nature 399:323-329(1999) [PubMed: 10360571] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U38840 Genomic DNA. Translation: AAB03727.1.
AE000512 Genomic DNA. Translation: AAD36795.1.
PIRA72217.
RefSeqNP_229528.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1IN4X-ray1.60A1-334[»]
1IN5X-ray2.00A1-334[»]
1IN6X-ray1.80A1-334[»]
1IN7X-ray1.90A1-334[»]
1IN8X-ray1.90A1-334[»]
1J7KX-ray1.80A1-334[»]
ModBaseSearch...

Genome annotation databases

GeneID897204.
GenomeReviewsGene locus TM_1730 in contig AE000512_GR.
KEGGtma:TM1730.
NMPDRfig|243274.1.peg.1712.
TIGRTM_1730.

Phylogenomic databases

HOGENOMQ56313.
OMAEKFDGGP.

Enzyme and pathway databases

BioCycTMAR243274:TM_1730-MON.

Family and domain databases

HAMAPMF_00016.
[Tree]
InterProIPR003593. ATPase_AAA+_core.
IPR003959. ATPase_AAA_core.
IPR004605. DNA_helicase_Holl-junc_RuvB.
IPR008823. DNA_helicase_Holl-junc_RuvB_C.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR011991. Wing_hlx_DNA_bd.
[Graphical view]
Gene3DG3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PfamPF00004. AAA. 1 hit.
PF05491. RuvB_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00635. ruvB. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameRUVB_THEMA
AccessionPrimary (citable) accession number: Q56313
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 3, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents