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Q56301

- KPYK_THELN

UniProt

Q56301 - KPYK_THELN

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Protein

Pyruvate kinase

Gene

pki

Organism
Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

a divalent metal cationBy similarityNote: Divalent metal cations.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Metal bindingi38 – 381PotassiumBy similarity
Metal bindingi40 – 401PotassiumBy similarity
Metal bindingi70 – 701PotassiumBy similarity
Sitei221 – 2211Transition state stabilizerBy similarity
Metal bindingi223 – 2231MagnesiumBy similarity
Binding sitei246 – 2461Substrate; via amide nitrogenBy similarity
Metal bindingi247 – 2471MagnesiumBy similarity
Binding sitei247 – 2471Substrate; via amide nitrogenBy similarity
Binding sitei279 – 2791SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pki
ORF Names:OCC_05009
OrganismiThermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
Taxonomic identifieri523849 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000015502: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Pyruvate kinasePRO_0000112130Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Phylogenomic databases

KOiK00873.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56301-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELPSHKTKI IATIGPASKQ KETIKKMIKA GMSVARINFS HGTLEEHAKT
60 70 80 90 100
IETVRDVAEK LERRVAILGD LPGLKMRVGK IKGDSVTLRK GDKVVLTTRD
110 120 130 140 150
IEGDETTIPV EFKDLPKLVS KGDTIYLSDG YIMLRVEEVR ENEVECVVVN
160 170 180 190 200
GGILFSHKGI NIPKANLPIE AITPRDFEII EFAIEHGVDA IGLSFVGSVY
210 220 230 240 250
DVLKVKSFLE KKSADLFVIA KIERPDAVRN FDEILNAADG IMIARGDLGV
260 270 280 290 300
EMPIEKLPIM QKQLIKKTNL AAKPVITATQ MLVSMTTERI PKRAEVTDVA
310 320 330 340 350
NAILDGTDAV MLSEETAIGK YPVESVEMMA KIAKTTEEYR ESLGYSRLRA
360 370 380 390 400
WIDSLPKRST IKEAITRSVI DALCAIDIKY ILTPTRTGLT PRLISRFKPK
410 420 430 440 450
QWILAFSSSE RVCNNLAFSY GVYPFCMDEN FNEKDIIMLV KGLGIVKEDD
460 470
TVLLTEGRPI GKTVGTNTMR IFQIP
Length:475
Mass (Da):52,767
Last modified:May 14, 2014 - v2
Checksum:i7970729B9948B94A
GO

Sequence cautioni

The sequence CAA58793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231T → S in CAA58793. (PubMed:7642512)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP006670 Genomic DNA. Translation: EHR79867.1.
X83963 Genomic DNA. Translation: CAA58793.1. Different initiation.
PIRiA57418.
RefSeqiYP_008428436.1. NC_022084.1.

Genome annotation databases

GeneIDi16548766.
KEGGitlt:OCC_05009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP006670 Genomic DNA. Translation: EHR79867.1 .
X83963 Genomic DNA. Translation: CAA58793.1 . Different initiation.
PIRi A57418.
RefSeqi YP_008428436.1. NC_022084.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 16548766.
KEGGi tlt:OCC_05009.

Phylogenomic databases

KOi K00873.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the model hyperthermophilic archaeon Thermococcus litoralis NS-C."
    Gardner A.F., Kumar S., Perler F.B.
    J. Bacteriol. 194:2375-2376(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51850 / DSM 5473 / JCM 8560 / NS-C.
  2. "Molecular characterization of the genes encoding the tungsten-containing aldehyde ferredoxin oxidoreductase from Pyrococcus furiosus and formaldehyde ferredoxin oxidoreductase from Thermococcus litoralis."
    Kletzin A., Mukund S., Kelley-Crouse T.L., Chan M.K.S., Rees D.C., Adams M.W.W.
    J. Bacteriol. 177:4817-4819(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-216.
    Strain: ATCC 51850 / DSM 5473 / JCM 8560 / NS-C.

Entry informationi

Entry nameiKPYK_THELN
AccessioniPrimary (citable) accession number: Q56301
Secondary accession number(s): H3ZJK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 14, 2014
Last modified: November 26, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3