SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q56301

- KPYK_THELN

UniProt

Q56301 - KPYK_THELN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Pyruvate kinase
Gene
pki, OCC_05009
Organism
Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Divalent metal cations By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Substrate By similarity
Metal bindingi38 – 381Potassium By similarity
Metal bindingi40 – 401Potassium By similarity
Metal bindingi70 – 701Potassium By similarity
Sitei221 – 2211Transition state stabilizer By similarity
Metal bindingi223 – 2231Magnesium By similarity
Binding sitei246 – 2461Substrate; via amide nitrogen By similarity
Metal bindingi247 – 2471Magnesium By similarity
Binding sitei247 – 2471Substrate; via amide nitrogen By similarity
Binding sitei279 – 2791Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pki
ORF Names:OCC_05009
OrganismiThermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
Taxonomic identifieri523849 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000015502: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Pyruvate kinase
PRO_0000112130Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ56301.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56301-1 [UniParc]FASTAAdd to Basket

« Hide

MELPSHKTKI IATIGPASKQ KETIKKMIKA GMSVARINFS HGTLEEHAKT    50
IETVRDVAEK LERRVAILGD LPGLKMRVGK IKGDSVTLRK GDKVVLTTRD 100
IEGDETTIPV EFKDLPKLVS KGDTIYLSDG YIMLRVEEVR ENEVECVVVN 150
GGILFSHKGI NIPKANLPIE AITPRDFEII EFAIEHGVDA IGLSFVGSVY 200
DVLKVKSFLE KKSADLFVIA KIERPDAVRN FDEILNAADG IMIARGDLGV 250
EMPIEKLPIM QKQLIKKTNL AAKPVITATQ MLVSMTTERI PKRAEVTDVA 300
NAILDGTDAV MLSEETAIGK YPVESVEMMA KIAKTTEEYR ESLGYSRLRA 350
WIDSLPKRST IKEAITRSVI DALCAIDIKY ILTPTRTGLT PRLISRFKPK 400
QWILAFSSSE RVCNNLAFSY GVYPFCMDEN FNEKDIIMLV KGLGIVKEDD 450
TVLLTEGRPI GKTVGTNTMR IFQIP 475
Length:475
Mass (Da):52,767
Last modified:May 14, 2014 - v2
Checksum:i7970729B9948B94A
GO

Sequence cautioni

The sequence CAA58793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231T → S in CAA58793. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP006670 Genomic DNA. Translation: EHR79867.1.
X83963 Genomic DNA. Translation: CAA58793.1. Different initiation.
PIRiA57418.
RefSeqiWP_004066098.1. NC_022084.1.
YP_008428436.1. NC_022084.1.

Genome annotation databases

GeneIDi16548766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP006670 Genomic DNA. Translation: EHR79867.1 .
X83963 Genomic DNA. Translation: CAA58793.1 . Different initiation.
PIRi A57418.
RefSeqi WP_004066098.1. NC_022084.1.
YP_008428436.1. NC_022084.1.

3D structure databases

ProteinModelPortali Q56301.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 16548766.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the model hyperthermophilic archaeon Thermococcus litoralis NS-C."
    Gardner A.F., Kumar S., Perler F.B.
    J. Bacteriol. 194:2375-2376(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51850 / DSM 5473 / JCM 8560 / NS-C.
  2. "Molecular characterization of the genes encoding the tungsten-containing aldehyde ferredoxin oxidoreductase from Pyrococcus furiosus and formaldehyde ferredoxin oxidoreductase from Thermococcus litoralis."
    Kletzin A., Mukund S., Kelley-Crouse T.L., Chan M.K.S., Rees D.C., Adams M.W.W.
    J. Bacteriol. 177:4817-4819(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-216.
    Strain: ATCC 51850 / DSM 5473 / JCM 8560 / NS-C.

Entry informationi

Entry nameiKPYK_THELN
AccessioniPrimary (citable) accession number: Q56301
Secondary accession number(s): H3ZJK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 14, 2014
Last modified: September 3, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi