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Q56301 (KPYK_THELI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
Gene names
Name:pki
OrganismThermococcus litoralis
Taxonomic identifier2265 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

Protein attributes

Sequence length220 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›220›220Pyruvate kinase
PRO_0000112130

Sites

Metal binding421Potassium By similarity
Metal binding441Potassium By similarity
Metal binding741Potassium By similarity
Binding site401Substrate By similarity

Experimental info

Non-terminal residue2201

Sequences

Sequence LengthMass (Da)Tools
Q56301 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A60B906BC742FCAA

FASTA22024,338
        10         20         30         40         50         60 
MVREMELPSH KTKIIATIGP ASKQKESIKK MIKAGMSVAR INFSHGTLEE HAKTIETVRD 

        70         80         90        100        110        120 
VAEKLERRVA ILGDLPGLKM RVGKIKGDSV TLRKGDKVVL TTRDIEGDET TIPVEFKDLP 

       130        140        150        160        170        180 
KLVSKGDTIY LSDGYIMLRV EEVRENEVEC VVVNGGILFS HKGINIPKAN LPIEAITPRD 

       190        200        210        220 
FEIIEFAIEH GVDAIGLSFV GSVYDVLKVK SFLEKKSADL 

« Hide

References

[1]"Molecular characterization of the genes encoding the tungsten-containing aldehyde ferredoxin oxidoreductase from Pyrococcus furiosus and formaldehyde ferredoxin oxidoreductase from Thermococcus litoralis."
Kletzin A., Mukund S., Kelley-Crouse T.L., Chan M.K.S., Rees D.C., Adams M.W.W.
J. Bacteriol. 177:4817-4819(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 5473.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X83963 Genomic DNA. Translation: CAA58793.1.
PIRA57418.

3D structure databases

ProteinModelPortalQ56301.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015793. Pyrv_Knase_brl.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
[Graphical view]
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
ProtoNetSearch...

Entry information

Entry nameKPYK_THELI
AccessionPrimary (citable) accession number: Q56301
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways