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Protein

Beta-actin-like protein 2

Gene

ACTBL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ562R1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-actin-like protein 2
Alternative name(s):
Kappa-actin
Gene namesi
Name:ACTBL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:17780. ACTBL2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672651.

Polymorphism and mutation databases

BioMutaiACTBL2.
DMDMi172046825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Beta-actin-like protein 2PRO_0000318849Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Methionine (R)-sulfoxideBy similarity
Modified residuei48 – 481Methionine (R)-sulfoxideBy similarity

Post-translational modificationi

Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).By similarity
Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity).By similarity

Keywords - PTMi

Oxidation

Proteomic databases

EPDiQ562R1.
MaxQBiQ562R1.
PaxDbiQ562R1.
PeptideAtlasiQ562R1.
PRIDEiQ562R1.

PTM databases

iPTMnetiQ562R1.
PhosphoSiteiQ562R1.
SwissPalmiQ562R1.

Expressioni

Gene expression databases

CleanExiHS_ACTBL2.

Organism-specific databases

HPAiHPA041264.
HPA041271.

Interactioni

Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with PFN1 and PFDN1.By similarity1 Publication

Protein-protein interaction databases

BioGridi131362. 160 interactions.
IntActiQ562R1. 25 interactions.
STRINGi9606.ENSP00000416706.

Structurei

3D structure databases

ProteinModelPortaliQ562R1.
SMRiQ562R1. Positions 7-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233339.
HOVERGENiHBG003771.
InParanoidiQ562R1.
OMAiMIGRPRH.
OrthoDBiEOG72RMZ1.
PhylomeDBiQ562R1.
TreeFamiTF354237.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q562R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNELSALV VDNGSGMCKA GFGGDDAPRA VFPSMIGRPR HQGVMVGMGQ
60 70 80 90 100
KDCYVGDEAQ SKRGVLTLKY PIEHGVVTNW DDMEKIWYHT FYNELRVAPD
110 120 130 140 150
EHPILLTEAP LNPKINREKM TQIMFEAFNT PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVMDSGDGV THIVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYN
210 220 230 240 250
FTTTAEREIV RDVKEKLCYV ALDFEQEMVR AAASSSPERS YELPDGQVIT
260 270 280 290 300
IGNERFRCPE AIFQPSFLGI ESSGIHETTF NSIMKCDVDI RKDLYANTVL
310 320 330 340 350
SGGSTMYPGI ADRMQKEIIT LAPSTMKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK QEYDEAGPPI VHRKCF
Length:376
Mass (Da):42,003
Last modified:February 26, 2008 - v2
Checksum:i6095D374964D71DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211T → I in AAX82242 (PubMed:16824795).Curated
Sequence conflicti135 – 1351V → A in AAX82260 (PubMed:16824795).Curated
Sequence conflicti162 – 1621H → L in AAX82259 (PubMed:16824795).Curated
Sequence conflicti163 – 1631I → T in AAX82193 (PubMed:16824795).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648504 mRNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54967.1.
BC137470 mRNA. Translation: AAI37471.1.
BC137473 mRNA. Translation: AAI37474.1.
AY970384 Genomic DNA. Translation: AAX82193.1.
AY970433 Genomic DNA. Translation: AAX82242.1.
AY970451 Genomic DNA. Translation: AAX82259.1.
AY970452 Genomic DNA. Translation: AAX82260.1.
CCDSiCCDS34163.1.
RefSeqiNP_001017992.1. NM_001017992.3.
UniGeneiHs.482167.

Genome annotation databases

EnsembliENST00000423391; ENSP00000416706; ENSG00000169067.
GeneIDi345651.
KEGGihsa:345651.
UCSCiuc003jrm.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648504 mRNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54967.1.
BC137470 mRNA. Translation: AAI37471.1.
BC137473 mRNA. Translation: AAI37474.1.
AY970384 Genomic DNA. Translation: AAX82193.1.
AY970433 Genomic DNA. Translation: AAX82242.1.
AY970451 Genomic DNA. Translation: AAX82259.1.
AY970452 Genomic DNA. Translation: AAX82260.1.
CCDSiCCDS34163.1.
RefSeqiNP_001017992.1. NM_001017992.3.
UniGeneiHs.482167.

3D structure databases

ProteinModelPortaliQ562R1.
SMRiQ562R1. Positions 7-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131362. 160 interactions.
IntActiQ562R1. 25 interactions.
STRINGi9606.ENSP00000416706.

PTM databases

iPTMnetiQ562R1.
PhosphoSiteiQ562R1.
SwissPalmiQ562R1.

Polymorphism and mutation databases

BioMutaiACTBL2.
DMDMi172046825.

Proteomic databases

EPDiQ562R1.
MaxQBiQ562R1.
PaxDbiQ562R1.
PeptideAtlasiQ562R1.
PRIDEiQ562R1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423391; ENSP00000416706; ENSG00000169067.
GeneIDi345651.
KEGGihsa:345651.
UCSCiuc003jrm.3. human.

Organism-specific databases

CTDi345651.
GeneCardsiACTBL2.
HGNCiHGNC:17780. ACTBL2.
HPAiHPA041264.
HPA041271.
MIMi614835. gene.
neXtProtiNX_Q562R1.
PharmGKBiPA142672651.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233339.
HOVERGENiHBG003771.
InParanoidiQ562R1.
OMAiMIGRPRH.
OrthoDBiEOG72RMZ1.
PhylomeDBiQ562R1.
TreeFamiTF354237.

Enzyme and pathway databases

SignaLinkiQ562R1.

Miscellaneous databases

GenomeRNAii345651.
PROiQ562R1.
SOURCEiSearch...

Gene expression databases

CleanExiHS_ACTBL2.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Endometrial tumor.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Identification of a novel actin isoform in hepatocellular carcinoma."
    Chang K.-W., Yang P.-Y., Lai H.-Y., Yeh T.-S., Chen T.-C., Yeh C.-T.
    Hepatol. Res. 36:33-39(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-187, INTERACTION WITH PFN1 AND PFDN1.
    Tissue: Hepatoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiACTBL_HUMAN
AccessioniPrimary (citable) accession number: Q562R1
Secondary accession number(s): B2RPJ1
, Q562R2, Q562S9, Q562X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 8, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.