Q562R1 (ACTBL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-actin-like protein 2

Alternative name(s):
Kappa-actin

Gene names

Name:

ACTBL2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells By similarity.
Subunit structure	Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others By similarity. Interacts with PFN1 and PFDN1. Ref.4
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Miscellaneous	In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Beta-actin-like protein 2		PRO_0000318849
Experimental info
	Sequence conflict	121	1	T → I in AAX82242. Ref.4
	Sequence conflict	135	1	V → A in AAX82260. Ref.4
	Sequence conflict	162	1	H → L in AAX82259. Ref.4
	Sequence conflict	163	1	I → T in AAX82193. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q562R1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 6095D374964D71DA	FASTA	376	42,003
	10 20 30 40 50 60 MTDNELSALV VDNGSGMCKA GFGGDDAPRA VFPSMIGRPR HQGVMVGMGQ KDCYVGDEAQ 70 80 90 100 110 120 SKRGVLTLKY PIEHGVVTNW DDMEKIWYHT FYNELRVAPD EHPILLTEAP LNPKINREKM 130 140 150 160 170 180 TQIMFEAFNT PAMYVAIQAV LSLYASGRTT GIVMDSGDGV THIVPIYEGY ALPHAILRLD 190 200 210 220 230 240 LAGRDLTDYL MKILTERGYN FTTTAEREIV RDVKEKLCYV ALDFEQEMVR AAASSSPERS 250 260 270 280 290 300 YELPDGQVIT IGNERFRCPE AIFQPSFLGI ESSGIHETTF NSIMKCDVDI RKDLYANTVL 310 320 330 340 350 360 SGGSTMYPGI ADRMQKEIIT LAPSTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK 370 QEYDEAGPPI VHRKCF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Endometrial tumor.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Identification of a novel actin isoform in hepatocellular carcinoma." Chang K.-W., Yang P.-Y., Lai H.-Y., Yeh T.-S., Chen T.-C., Yeh C.-T. Hepatol. Res. 36:33-39(2006) [PubMed: 16824795] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-187, INTERACTION WITH PFN1 AND PFDN1. Tissue: Hepatoma.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX648504 mRNA. No translation available. CH471123 Genomic DNA. Translation: EAW54967.1. BC137470 mRNA. Translation: AAI37471.1. BC137473 mRNA. Translation: AAI37474.1. AY970384 Genomic DNA. Translation: AAX82193.1. AY970433 Genomic DNA. Translation: AAX82242.1. AY970451 Genomic DNA. Translation: AAX82259.1. AY970452 Genomic DNA. Translation: AAX82260.1.
IPI	IPI00003269.
RefSeq	NP_001017992.1. NM_001017992.2.
UniGene	Hs.482167.
3D structure databases
ProteinModelPortal	Q562R1.
SMR	Q562R1. Positions 3-376.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q562R1. 7 interactions.
STRING	Q562R1.
PTM databases
PhosphoSite	Q562R1.
Polymorphism databases
DMDM	172046825.
Proteomic databases
PeptideAtlas	Q562R1.
PRIDE	Q562R1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000423391; ENSP00000416706; ENSG00000169067.
GeneID	345651.
KEGG	hsa:345651.
UCSC	uc003jrm.1. human.
Organism-specific databases
CTD	345651.
GeneCards	GC05M056813.
H-InvDB	HIX0024988.
HGNC	HGNC:17780. ACTBL2.
neXtProt	NX_Q562R1.
PharmGKB	PA142672651.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18118.
GeneTree	ENSGT00590000082732.
HOGENOM	HBG559892.
HOVERGEN	HBG003771.
InParanoid	Q562R1.
OMA	MVGRPRH.
OrthoDB	EOG47SSDV.
PhylomeDB	Q562R1.
Gene expression databases
ArrayExpress	Q562R1.
CleanEx	HS_ACTBL2.
Genevestigator	Q562R1.
Family and domain databases
InterPro	IPR004000. Actin-like. IPR020902. Actin/actin-like_CS. IPR004001. Actin_CS. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. 1 hit. PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	98897.

Entry information

Entry name

ACTBL_HUMAN

Accession

Primary (citable) accession number: Q562R1
Secondary accession number(s): B2RPJ1 , Q562R2, Q562S9, Q562X8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.