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Q562F6

- SGOL2_HUMAN

UniProt

Q562F6 - SGOL2_HUMAN

Protein

Shugoshin-like 2

Gene

SGOL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation By similarity. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.By similarity2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. meiotic sister chromatid cohesion, centromeric Source: InterPro
    2. mitotic cell cycle Source: Reactome

    Keywords - Biological processi

    Cell cycle, Cell division, Chromosome partition, Meiosis

    Enzyme and pathway databases

    ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_682. Mitotic Prometaphase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Shugoshin-like 2
    Alternative name(s):
    Shugoshin-2
    Short name:
    Sgo2
    Tripin
    Gene namesi
    Name:SGOL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:30812. SGOL2.

    Subcellular locationi

    Nucleus. Chromosomecentromere. Chromosomecentromerekinetochore By similarity
    Note: During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres. SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost. During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis By similarity. In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase. Centromeric localization requires the presence of BUB1 and AUKRB.By similarity

    GO - Cellular componenti

    1. chromosome, centromeric region Source: UniProtKB
    2. condensed chromosome kinetochore Source: UniProtKB-SubCell
    3. cytosol Source: Reactome
    4. mitotic cohesin complex Source: MGI
    5. nucleus Source: HPA

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134901462.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12651265Shugoshin-like 2PRO_0000055439Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1144 – 11441Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ562F6.
    PaxDbiQ562F6.
    PRIDEiQ562F6.

    PTM databases

    PhosphoSiteiQ562F6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ562F6.
    BgeeiQ562F6.
    CleanExiHS_SGOL2.
    GenevestigatoriQ562F6.

    Organism-specific databases

    HPAiHPA035163.
    HPA040817.

    Interactioni

    Subunit structurei

    Directly interacts with PPP2CA. Part of an astrin (SPAG5) -kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAD2L1Q1325710EBI-989213,EBI-78203
    MAD2L1BPQ150132EBI-989213,EBI-712181
    PPP1CAP621364EBI-989213,EBI-357253

    Protein-protein interaction databases

    BioGridi127357. 6 interactions.
    DIPiDIP-36615N.
    IntActiQ562F6. 15 interactions.
    MINTiMINT-4995654.
    STRINGi9606.ENSP00000350447.

    Structurei

    3D structure databases

    ProteinModelPortaliQ562F6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili69 – 11648Sequence AnalysisAdd
    BLAST
    Coiled coili452 – 47625Sequence AnalysisAdd
    BLAST
    Coiled coili603 – 62624Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the shugoshin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG25773.
    HOVERGENiHBG093950.
    InParanoidiQ562F6.
    KOiK11581.
    OMAiKVNRKTE.
    OrthoDBiEOG790G02.
    PhylomeDBiQ562F6.
    TreeFamiTF350100.

    Family and domain databases

    InterProiIPR026706. SGOL2.
    [Graphical view]
    PANTHERiPTHR21577:SF2. PTHR21577:SF2. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q562F6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MECPVMETGS LFTSGIKRHL KDKRISKTTK LNVSLASKIK TKILNNSSIF     50
    KISLKHNNRA LAQALSREKE NSRRITTEKM LLQKEVEKLN FENTFLRLKL 100
    NNLNKKLIDI EALMNNNLIT AIEMSSLSEF HQSSFLLSAS KKKRISKQCK 150
    LMRLPFARVP LTSNDDEDED KEKMQCDNNI KSKTLPDIPS SGSTTQPLST 200
    QDNSEVLFLK ENNQNVYGLD DSEHISSIVD VPPRESHSHS DQSSKTSLMS 250
    EMRNAQSIGR RWEKPSPSNV TERKKRGSSW ESNNLSADTP CATVLDKQHI 300
    SSPELNCNNE INGHTNETNT EMQRNKQDLP GLSSESAREP NAECMNQIED 350
    NDDFQLQKTV YDADMDLTAS EVSKIVTVST GIKKKSNKKT NEHGMKTFRK 400
    VKDSSSEKKR ERSKRQFKNS SDVDIGEKIE NRTERSDVLD GKRGAEDPGF 450
    IFNNEQLAQM NEQLAQVNEL KKMTLQTGFE QGDRENVLCN KKEKRITNEQ 500
    EETYSLSQSS GKFHQESKFD KGQNSLTCNK SKASRQTFVI HKLEKDNLLP 550
    NQKDKVTIYE NLDVTNEFHT ANLSTKDNGN LCDYGTHNIL DLKKYVTDIQ 600
    PSEQNESNIN KLRKKVNRKT EIISGMNHMY EDNDKDVVHG LKKGNFFFKT 650
    QEDKEPISEN IEVSKELQIP ALSTRDNENQ CDYRTQNVLG LQKQITNMYP 700
    VQQNESKVNK KLRQKVNRKT EIISEVNHLD NDKSIEYTVK SHSLFLTQKD 750
    KEIIPGNLED PSEFETPALS TKDSGNLYDS EIQNVLGVKH GHDMQPACQN 800
    DSKIGKKPRL NVCQKSEIIP ETNQIYENDN KGVHDLEKDN FFSLTPKDKE 850
    TISENLQVTN EFQTVDLLIK DNGNLCDYDT QNILELKKYV TDRKSAEQNE 900
    SKINKLRNKV NWKTEIISEM NQIYEDNDKD AHVQESYTKD LDFKVNKSKQ 950
    KLECQDIINK HYMEVNSNEK ESCDQILDSY KVVKKRKKES SCKAKNILTK 1000
    AKNKLASQLT ESSQTSISLE SDLKHITSEA DSDPGNPVEL CKTQKQSTTT 1050
    LNKKDLPFVE EIKEGECQVK KVNKMTSKSK KRKTSIDPSP ESHEVMERIL 1100
    DSVQGKSTVS EQADKENNLE NEKMVKNKPD FYTKAFRSLS EIHSPNIQDS 1150
    SFDSVREGLV PLSVSSGKNV IIKENFALEC SPAFQVSDDE HEKMNKMKFK 1200
    VNRRTQKSGI GDRPLQDLSN TSFVSNNTAE SENKSEDLSS ERTSRRRRCT 1250
    PFYFKEPSLR DKMRR 1265
    Length:1,265
    Mass (Da):144,739
    Last modified:January 10, 2006 - v2
    Checksum:i6A678CB3E6DF72D7
    GO
    Isoform 2 (identifier: Q562F6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1261-1265: DKMRR → E

    Note: No experimental confirmation available.

    Show »
    Length:1,261
    Mass (Da):144,181
    Checksum:iA76F72D7168C9FC7
    GO
    Isoform 3 (identifier: Q562F6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         235-247: ESHSHSDQSSKTS → GEIVLKIHFEYLY
         248-1265: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:247
    Mass (Da):28,230
    Checksum:i32F5E22581F1A7D9
    GO

    Sequence cautioni

    The sequence AAH35764.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAC04524.1 differs from that shown. Reason: Frameshift at position 649.
    The sequence BAB71617.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti122 – 1221I → T in BX647433. (PubMed:17974005)Curated
    Sequence conflicti145 – 1451I → V in BX647433. (PubMed:17974005)Curated
    Sequence conflicti193 – 1931S → R in AAM21971. 1 PublicationCurated
    Sequence conflicti205 – 2051E → G in AAM21971. 1 PublicationCurated
    Sequence conflicti215 – 2151N → H in AAM21971. 1 PublicationCurated
    Sequence conflicti450 – 4512FI → LF in AAM21971. 1 PublicationCurated
    Sequence conflicti1243 – 12431T → A in BAB71617. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91G → D.1 Publication
    Corresponds to variant rs1036533 [ dbSNP | Ensembl ].
    VAR_024784
    Natural varianti343 – 3431E → A.
    Corresponds to variant rs13417812 [ dbSNP | Ensembl ].
    VAR_057178
    Natural varianti496 – 4961I → V.1 Publication
    Corresponds to variant rs17448235 [ dbSNP | Ensembl ].
    VAR_024785
    Natural varianti660 – 6601N → S.1 Publication
    Corresponds to variant rs17532665 [ dbSNP | Ensembl ].
    VAR_057179
    Natural varianti1099 – 10991I → T.
    Corresponds to variant rs11896759 [ dbSNP | Ensembl ].
    VAR_057180
    Natural varianti1143 – 11431H → R.
    Corresponds to variant rs16833776 [ dbSNP | Ensembl ].
    VAR_057181

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei235 – 24713ESHSH…SSKTS → GEIVLKIHFEYLY in isoform 3. 1 PublicationVSP_016798Add
    BLAST
    Alternative sequencei248 – 12651018Missing in isoform 3. 1 PublicationVSP_016799Add
    BLAST
    Alternative sequencei1261 – 12655DKMRR → E in isoform 2. 1 PublicationVSP_016800

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY094614 mRNA. Translation: AAM21971.1.
    AK057940 mRNA. Translation: BAB71617.1. Different initiation.
    AK095291 mRNA. Translation: BAC04524.1. Frameshift.
    BX647433 mRNA. No translation available.
    AC012459 Genomic DNA. Translation: AAY24310.1.
    AC080164 Genomic DNA. Translation: AAY24264.1.
    BC035764 mRNA. Translation: AAH35764.1. Sequence problems.
    BC048349 mRNA. Translation: AAH48349.1.
    BC092412 mRNA. Translation: AAH92412.1.
    CCDSiCCDS42796.1. [Q562F6-1]
    RefSeqiNP_001153518.1. NM_001160046.1. [Q562F6-2]
    NP_689737.4. NM_152524.5. [Q562F6-1]
    XP_005246402.1. XM_005246345.1. [Q562F6-1]
    UniGeneiHs.655182.

    Genome annotation databases

    EnsembliENST00000357799; ENSP00000350447; ENSG00000163535. [Q562F6-1]
    ENST00000409203; ENSP00000386249; ENSG00000163535. [Q562F6-3]
    GeneIDi151246.
    KEGGihsa:151246.
    UCSCiuc002uvv.4. human. [Q562F6-3]
    uc002uvw.2. human. [Q562F6-1]
    uc010zhd.1. human. [Q562F6-2]

    Polymorphism databases

    DMDMi85542144.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY094614 mRNA. Translation: AAM21971.1 .
    AK057940 mRNA. Translation: BAB71617.1 . Different initiation.
    AK095291 mRNA. Translation: BAC04524.1 . Frameshift.
    BX647433 mRNA. No translation available.
    AC012459 Genomic DNA. Translation: AAY24310.1 .
    AC080164 Genomic DNA. Translation: AAY24264.1 .
    BC035764 mRNA. Translation: AAH35764.1 . Sequence problems.
    BC048349 mRNA. Translation: AAH48349.1 .
    BC092412 mRNA. Translation: AAH92412.1 .
    CCDSi CCDS42796.1. [Q562F6-1 ]
    RefSeqi NP_001153518.1. NM_001160046.1. [Q562F6-2 ]
    NP_689737.4. NM_152524.5. [Q562F6-1 ]
    XP_005246402.1. XM_005246345.1. [Q562F6-1 ]
    UniGenei Hs.655182.

    3D structure databases

    ProteinModelPortali Q562F6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127357. 6 interactions.
    DIPi DIP-36615N.
    IntActi Q562F6. 15 interactions.
    MINTi MINT-4995654.
    STRINGi 9606.ENSP00000350447.

    PTM databases

    PhosphoSitei Q562F6.

    Polymorphism databases

    DMDMi 85542144.

    Proteomic databases

    MaxQBi Q562F6.
    PaxDbi Q562F6.
    PRIDEi Q562F6.

    Protocols and materials databases

    DNASUi 151246.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357799 ; ENSP00000350447 ; ENSG00000163535 . [Q562F6-1 ]
    ENST00000409203 ; ENSP00000386249 ; ENSG00000163535 . [Q562F6-3 ]
    GeneIDi 151246.
    KEGGi hsa:151246.
    UCSCi uc002uvv.4. human. [Q562F6-3 ]
    uc002uvw.2. human. [Q562F6-1 ]
    uc010zhd.1. human. [Q562F6-2 ]

    Organism-specific databases

    CTDi 151246.
    GeneCardsi GC02P201375.
    HGNCi HGNC:30812. SGOL2.
    HPAi HPA035163.
    HPA040817.
    MIMi 612425. gene.
    neXtProti NX_Q562F6.
    PharmGKBi PA134901462.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25773.
    HOVERGENi HBG093950.
    InParanoidi Q562F6.
    KOi K11581.
    OMAi KVNRKTE.
    OrthoDBi EOG790G02.
    PhylomeDBi Q562F6.
    TreeFami TF350100.

    Enzyme and pathway databases

    Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_682. Mitotic Prometaphase.

    Miscellaneous databases

    GeneWikii SGOL2.
    GenomeRNAii 151246.
    NextBioi 86645.
    PROi Q562F6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q562F6.
    Bgeei Q562F6.
    CleanExi HS_SGOL2.
    Genevestigatori Q562F6.

    Family and domain databases

    InterProi IPR026706. SGOL2.
    [Graphical view ]
    PANTHERi PTHR21577:SF2. PTHR21577:SF2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of TRIPIN: an inhibitor of TRIP function on TRAF2 mediated activation of NF-kB."
      Oliveira V., Fiorentino L., Chan H., Matsuzawa S., Chu Z., Saraiva M.J., Reed J.C.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-496 AND SER-660.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 698-1265 (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon endothelium.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ASP-9.
      Tissue: Lymph, Testis and Uterus.
    6. "Shugoshin collaborates with protein phosphatase 2A to protect cohesin."
      Kitajima T.S., Sakuno T., Ishiguro K., Iemura S., Natsume T., Kawashima S.A., Watanabe Y.
      Nature 441:46-52(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PPP2CA.
    7. "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments."
      Huang H., Feng J., Famulski J., Rattner J.B., Liu S.T., Kao G.D., Muschel R., Chan G.K., Yen T.J.
      J. Cell Biol. 177:413-424(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PPP2CA.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment."
      Dunsch A.K., Linnane E., Barr F.A., Gruneberg U.
      J. Cell Biol. 192:959-968(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH KNSTRN; SPAG5; PLK1 AND DYNLL1.

    Entry informationi

    Entry nameiSGOL2_HUMAN
    AccessioniPrimary (citable) accession number: Q562F6
    Secondary accession number(s): Q53RR9
    , Q53T20, Q86XY4, Q8IWK2, Q8IZK1, Q8N1Q5, Q96LQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3