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Q562F6

- SGOL2_HUMAN

UniProt

Q562F6 - SGOL2_HUMAN

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Protein

Shugoshin-like 2

Gene

SGOL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation By similarity. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.By similarity2 Publications

GO - Biological processi

  1. meiotic sister chromatid cohesion, centromeric Source: InterPro
  2. mitotic cell cycle Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Meiosis

Enzyme and pathway databases

ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_682. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Shugoshin-like 2
Alternative name(s):
Shugoshin-2
Short name:
Sgo2
Tripin
Gene namesi
Name:SGOL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:30812. SGOL2.

Subcellular locationi

Nucleus. Chromosomecentromere. Chromosomecentromerekinetochore By similarity
Note: During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres. SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost. During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis By similarity. In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase. Centromeric localization requires the presence of BUB1 and AUKRB.By similarity

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB
  2. cytosol Source: Reactome
  3. kinetochore Source: UniProtKB-KW
  4. mitotic cohesin complex Source: MGI
  5. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12651265Shugoshin-like 2PRO_0000055439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1144 – 11441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ562F6.
PaxDbiQ562F6.
PRIDEiQ562F6.

PTM databases

PhosphoSiteiQ562F6.

Expressioni

Gene expression databases

BgeeiQ562F6.
CleanExiHS_SGOL2.
ExpressionAtlasiQ562F6. baseline and differential.
GenevestigatoriQ562F6.

Organism-specific databases

HPAiHPA035163.
HPA040817.

Interactioni

Subunit structurei

Directly interacts with PPP2CA. Part of an astrin (SPAG5) -kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAD2L1Q1325710EBI-989213,EBI-78203
MAD2L1BPQ150132EBI-989213,EBI-712181
PPP1CAP621364EBI-989213,EBI-357253

Protein-protein interaction databases

BioGridi127357. 33 interactions.
DIPiDIP-36615N.
IntActiQ562F6. 15 interactions.
MINTiMINT-4995654.
STRINGi9606.ENSP00000350447.

Structurei

3D structure databases

ProteinModelPortaliQ562F6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili69 – 11648Sequence AnalysisAdd
BLAST
Coiled coili452 – 47625Sequence AnalysisAdd
BLAST
Coiled coili603 – 62624Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the shugoshin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG25773.
GeneTreeiENSGT00390000016383.
HOVERGENiHBG093950.
InParanoidiQ562F6.
KOiK11581.
OMAiKVNRKTE.
OrthoDBiEOG790G02.
PhylomeDBiQ562F6.
TreeFamiTF350100.

Family and domain databases

InterProiIPR026706. SGOL2.
[Graphical view]
PANTHERiPTHR21577:SF2. PTHR21577:SF2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q562F6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MECPVMETGS LFTSGIKRHL KDKRISKTTK LNVSLASKIK TKILNNSSIF
60 70 80 90 100
KISLKHNNRA LAQALSREKE NSRRITTEKM LLQKEVEKLN FENTFLRLKL
110 120 130 140 150
NNLNKKLIDI EALMNNNLIT AIEMSSLSEF HQSSFLLSAS KKKRISKQCK
160 170 180 190 200
LMRLPFARVP LTSNDDEDED KEKMQCDNNI KSKTLPDIPS SGSTTQPLST
210 220 230 240 250
QDNSEVLFLK ENNQNVYGLD DSEHISSIVD VPPRESHSHS DQSSKTSLMS
260 270 280 290 300
EMRNAQSIGR RWEKPSPSNV TERKKRGSSW ESNNLSADTP CATVLDKQHI
310 320 330 340 350
SSPELNCNNE INGHTNETNT EMQRNKQDLP GLSSESAREP NAECMNQIED
360 370 380 390 400
NDDFQLQKTV YDADMDLTAS EVSKIVTVST GIKKKSNKKT NEHGMKTFRK
410 420 430 440 450
VKDSSSEKKR ERSKRQFKNS SDVDIGEKIE NRTERSDVLD GKRGAEDPGF
460 470 480 490 500
IFNNEQLAQM NEQLAQVNEL KKMTLQTGFE QGDRENVLCN KKEKRITNEQ
510 520 530 540 550
EETYSLSQSS GKFHQESKFD KGQNSLTCNK SKASRQTFVI HKLEKDNLLP
560 570 580 590 600
NQKDKVTIYE NLDVTNEFHT ANLSTKDNGN LCDYGTHNIL DLKKYVTDIQ
610 620 630 640 650
PSEQNESNIN KLRKKVNRKT EIISGMNHMY EDNDKDVVHG LKKGNFFFKT
660 670 680 690 700
QEDKEPISEN IEVSKELQIP ALSTRDNENQ CDYRTQNVLG LQKQITNMYP
710 720 730 740 750
VQQNESKVNK KLRQKVNRKT EIISEVNHLD NDKSIEYTVK SHSLFLTQKD
760 770 780 790 800
KEIIPGNLED PSEFETPALS TKDSGNLYDS EIQNVLGVKH GHDMQPACQN
810 820 830 840 850
DSKIGKKPRL NVCQKSEIIP ETNQIYENDN KGVHDLEKDN FFSLTPKDKE
860 870 880 890 900
TISENLQVTN EFQTVDLLIK DNGNLCDYDT QNILELKKYV TDRKSAEQNE
910 920 930 940 950
SKINKLRNKV NWKTEIISEM NQIYEDNDKD AHVQESYTKD LDFKVNKSKQ
960 970 980 990 1000
KLECQDIINK HYMEVNSNEK ESCDQILDSY KVVKKRKKES SCKAKNILTK
1010 1020 1030 1040 1050
AKNKLASQLT ESSQTSISLE SDLKHITSEA DSDPGNPVEL CKTQKQSTTT
1060 1070 1080 1090 1100
LNKKDLPFVE EIKEGECQVK KVNKMTSKSK KRKTSIDPSP ESHEVMERIL
1110 1120 1130 1140 1150
DSVQGKSTVS EQADKENNLE NEKMVKNKPD FYTKAFRSLS EIHSPNIQDS
1160 1170 1180 1190 1200
SFDSVREGLV PLSVSSGKNV IIKENFALEC SPAFQVSDDE HEKMNKMKFK
1210 1220 1230 1240 1250
VNRRTQKSGI GDRPLQDLSN TSFVSNNTAE SENKSEDLSS ERTSRRRRCT
1260
PFYFKEPSLR DKMRR
Length:1,265
Mass (Da):144,739
Last modified:January 10, 2006 - v2
Checksum:i6A678CB3E6DF72D7
GO
Isoform 2 (identifier: Q562F6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1261-1265: DKMRR → E

Note: No experimental confirmation available.

Show »
Length:1,261
Mass (Da):144,181
Checksum:iA76F72D7168C9FC7
GO
Isoform 3 (identifier: Q562F6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     235-247: ESHSHSDQSSKTS → GEIVLKIHFEYLY
     248-1265: Missing.

Note: No experimental confirmation available.

Show »
Length:247
Mass (Da):28,230
Checksum:i32F5E22581F1A7D9
GO

Sequence cautioni

The sequence AAH35764.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAC04524.1 differs from that shown. Reason: Frameshift at position 649.
The sequence BAB71617.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221I → T in BX647433. (PubMed:17974005)Curated
Sequence conflicti145 – 1451I → V in BX647433. (PubMed:17974005)Curated
Sequence conflicti193 – 1931S → R in AAM21971. 1 PublicationCurated
Sequence conflicti205 – 2051E → G in AAM21971. 1 PublicationCurated
Sequence conflicti215 – 2151N → H in AAM21971. 1 PublicationCurated
Sequence conflicti450 – 4512FI → LF in AAM21971. 1 PublicationCurated
Sequence conflicti1243 – 12431T → A in BAB71617. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91G → D.1 Publication
Corresponds to variant rs1036533 [ dbSNP | Ensembl ].
VAR_024784
Natural varianti343 – 3431E → A.
Corresponds to variant rs13417812 [ dbSNP | Ensembl ].
VAR_057178
Natural varianti496 – 4961I → V.1 Publication
Corresponds to variant rs17448235 [ dbSNP | Ensembl ].
VAR_024785
Natural varianti660 – 6601N → S.1 Publication
Corresponds to variant rs17532665 [ dbSNP | Ensembl ].
VAR_057179
Natural varianti1099 – 10991I → T.
Corresponds to variant rs11896759 [ dbSNP | Ensembl ].
VAR_057180
Natural varianti1143 – 11431H → R.
Corresponds to variant rs16833776 [ dbSNP | Ensembl ].
VAR_057181

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei235 – 24713ESHSH…SSKTS → GEIVLKIHFEYLY in isoform 3. 1 PublicationVSP_016798Add
BLAST
Alternative sequencei248 – 12651018Missing in isoform 3. 1 PublicationVSP_016799Add
BLAST
Alternative sequencei1261 – 12655DKMRR → E in isoform 2. 1 PublicationVSP_016800

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY094614 mRNA. Translation: AAM21971.1.
AK057940 mRNA. Translation: BAB71617.1. Different initiation.
AK095291 mRNA. Translation: BAC04524.1. Frameshift.
BX647433 mRNA. No translation available.
AC012459 Genomic DNA. Translation: AAY24310.1.
AC080164 Genomic DNA. Translation: AAY24264.1.
BC035764 mRNA. Translation: AAH35764.1. Sequence problems.
BC048349 mRNA. Translation: AAH48349.1.
BC092412 mRNA. Translation: AAH92412.1.
CCDSiCCDS42796.1. [Q562F6-1]
RefSeqiNP_001153518.1. NM_001160046.1. [Q562F6-2]
NP_689737.4. NM_152524.5. [Q562F6-1]
XP_005246402.1. XM_005246345.1. [Q562F6-1]
UniGeneiHs.655182.

Genome annotation databases

EnsembliENST00000357799; ENSP00000350447; ENSG00000163535. [Q562F6-1]
ENST00000409203; ENSP00000386249; ENSG00000163535. [Q562F6-3]
GeneIDi151246.
KEGGihsa:151246.
UCSCiuc002uvv.4. human. [Q562F6-3]
uc002uvw.2. human. [Q562F6-1]
uc010zhd.1. human. [Q562F6-2]

Polymorphism databases

DMDMi85542144.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY094614 mRNA. Translation: AAM21971.1 .
AK057940 mRNA. Translation: BAB71617.1 . Different initiation.
AK095291 mRNA. Translation: BAC04524.1 . Frameshift.
BX647433 mRNA. No translation available.
AC012459 Genomic DNA. Translation: AAY24310.1 .
AC080164 Genomic DNA. Translation: AAY24264.1 .
BC035764 mRNA. Translation: AAH35764.1 . Sequence problems.
BC048349 mRNA. Translation: AAH48349.1 .
BC092412 mRNA. Translation: AAH92412.1 .
CCDSi CCDS42796.1. [Q562F6-1 ]
RefSeqi NP_001153518.1. NM_001160046.1. [Q562F6-2 ]
NP_689737.4. NM_152524.5. [Q562F6-1 ]
XP_005246402.1. XM_005246345.1. [Q562F6-1 ]
UniGenei Hs.655182.

3D structure databases

ProteinModelPortali Q562F6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127357. 33 interactions.
DIPi DIP-36615N.
IntActi Q562F6. 15 interactions.
MINTi MINT-4995654.
STRINGi 9606.ENSP00000350447.

PTM databases

PhosphoSitei Q562F6.

Polymorphism databases

DMDMi 85542144.

Proteomic databases

MaxQBi Q562F6.
PaxDbi Q562F6.
PRIDEi Q562F6.

Protocols and materials databases

DNASUi 151246.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357799 ; ENSP00000350447 ; ENSG00000163535 . [Q562F6-1 ]
ENST00000409203 ; ENSP00000386249 ; ENSG00000163535 . [Q562F6-3 ]
GeneIDi 151246.
KEGGi hsa:151246.
UCSCi uc002uvv.4. human. [Q562F6-3 ]
uc002uvw.2. human. [Q562F6-1 ]
uc010zhd.1. human. [Q562F6-2 ]

Organism-specific databases

CTDi 151246.
GeneCardsi GC02P201375.
HGNCi HGNC:30812. SGOL2.
HPAi HPA035163.
HPA040817.
MIMi 612425. gene.
neXtProti NX_Q562F6.
PharmGKBi PA134901462.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25773.
GeneTreei ENSGT00390000016383.
HOVERGENi HBG093950.
InParanoidi Q562F6.
KOi K11581.
OMAi KVNRKTE.
OrthoDBi EOG790G02.
PhylomeDBi Q562F6.
TreeFami TF350100.

Enzyme and pathway databases

Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_682. Mitotic Prometaphase.

Miscellaneous databases

GeneWikii SGOL2.
GenomeRNAii 151246.
NextBioi 86645.
PROi Q562F6.
SOURCEi Search...

Gene expression databases

Bgeei Q562F6.
CleanExi HS_SGOL2.
ExpressionAtlasi Q562F6. baseline and differential.
Genevestigatori Q562F6.

Family and domain databases

InterProi IPR026706. SGOL2.
[Graphical view ]
PANTHERi PTHR21577:SF2. PTHR21577:SF2. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of TRIPIN: an inhibitor of TRIP function on TRAF2 mediated activation of NF-kB."
    Oliveira V., Fiorentino L., Chan H., Matsuzawa S., Chu Z., Saraiva M.J., Reed J.C.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-496 AND SER-660.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 698-1265 (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon endothelium.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ASP-9.
    Tissue: Lymph, Testis and Uterus.
  6. "Shugoshin collaborates with protein phosphatase 2A to protect cohesin."
    Kitajima T.S., Sakuno T., Ishiguro K., Iemura S., Natsume T., Kawashima S.A., Watanabe Y.
    Nature 441:46-52(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PPP2CA.
  7. "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments."
    Huang H., Feng J., Famulski J., Rattner J.B., Liu S.T., Kao G.D., Muschel R., Chan G.K., Yen T.J.
    J. Cell Biol. 177:413-424(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PPP2CA.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment."
    Dunsch A.K., Linnane E., Barr F.A., Gruneberg U.
    J. Cell Biol. 192:959-968(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH KNSTRN; SPAG5; PLK1 AND DYNLL1.

Entry informationi

Entry nameiSGOL2_HUMAN
AccessioniPrimary (citable) accession number: Q562F6
Secondary accession number(s): Q53RR9
, Q53T20, Q86XY4, Q8IWK2, Q8IZK1, Q8N1Q5, Q96LQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3