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Q562D6

- NAP1_MOUSE

UniProt

Q562D6 - NAP1_MOUSE

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Protein
Nef-associated protein 1
Gene
Nap1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes acyl-CoA thioesters (in vitro). Has a preference for substrates with medium chain length (C10-C14). Inactive towards substrates with C18 or C20 aliphatic chains. Its physiological substrate is not known By similarity.

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nef-associated protein 1 (EC:3.1.2.-)
    Alternative name(s):
    Thioesterase NAP1
    Gene namesi
    Name:Nap1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1922003. 5830415F09Rik.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Nef-associated protein 1
    PRO_0000288887Add
    BLAST

    Proteomic databases

    PRIDEiQ562D6.

    PTM databases

    PhosphoSiteiQ562D6.

    Expressioni

    Gene expression databases

    BgeeiQ562D6.
    CleanExiMM_5830415F09RIK.
    GenevestigatoriQ562D6.

    Interactioni

    Subunit structurei

    Interacts with lentivirus protein Nef By similarity.

    Protein-protein interaction databases

    IntActiQ562D6. 1 interaction.
    MINTiMINT-8414996.

    Structurei

    3D structure databases

    ProteinModelPortaliQ562D6.
    SMRiQ562D6. Positions 27-221.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 168139TsaA-like
    Add
    BLAST

    Sequence similaritiesi

    Contains 1 TsaA-like domain.

    Phylogenomic databases

    eggNOGiCOG1720.
    GeneTreeiENSGT00390000004643.
    HOGENOMiHOG000231645.
    HOVERGENiHBG054288.
    OMAiYEIACAP.
    TreeFamiTF331670.

    Family and domain databases

    Gene3Di2.40.30.70. 1 hit.
    InterProiIPR023370. TsaA-like.
    IPR001378. UPF0066.
    IPR023368. UPF0066_cons_site.
    [Graphical view]
    PfamiPF01980. UPF0066. 1 hit.
    [Graphical view]
    SUPFAMiSSF118196. SSF118196. 2 hits.
    TIGRFAMsiTIGR00104. YaeB_AF0241. 1 hit.
    PROSITEiPS01318. TSAA_1. 1 hit.
    PS51668. TSAA_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q562D6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRGLEKQGSC ATAAPCGCVQ PALEAGNLLT EPIGYLESCF PAKIGTPRQP    50
    SICSHSRACL KIRKNIFNNP EHSLMGLEEF SHVWILFVFH KNGHLNYKAK 100
    VQPPRLNGAK TGVFSTRSPH RPNAIGLTLA KLEKVEGGAV YLSGVDMIDG 150
    TPVLDIKPYI ADYDSPQNLS VHNDHHKLRA EAQVDGTANS CDQLLLSGRG 200
    KVQPRQSTKE RPKCLEDRTS GENSQKSRDM SEIQHTLPED RERALDLALE 250
    PSRGESMDMP ENQLGPPELK SFLEEGTDRP RKVEGALVLP GSSAETQWDA 300
    SYRARTADRV PYSVVPSWVT EAPVAPLQVR FTPHAEMDLR KLNSGDASQP 350
    SFKYFHSAEE AKRAIEAVLS ADPRSVYRRK LCEDRLFFFT VDTAHVTCWF 400
    GDGFAEVVRI KLASESVQVA DPEESLAALG S 431
    Length:431
    Mass (Da):47,559
    Last modified:May 29, 2007 - v2
    Checksum:i5C98C96BE6A6692B
    GO
    Isoform 2 (identifier: Q562D6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         419-431: VADPEESLAALGS → TVLPPSPSPN...PPLPQGLVFS

    Note: No experimental confirmation available.

    Show »
    Length:488
    Mass (Da):53,677
    Checksum:iA20D1CD4D29888AE
    GO
    Isoform 3 (identifier: Q562D6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-25: MRGLEKQGSCATAAPCGCVQPALEA → MWVRSAGPG

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

    Show »
    Length:415
    Mass (Da):46,027
    Checksum:i893560AF2A75659B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2525MRGLE…PALEA → MWVRSAGPG in isoform 3.
    VSP_025815Add
    BLAST
    Alternative sequencei419 – 43113VADPE…AALGS → TVLPPSPSPNGREEQSSVEE EVQQRAGPSRRAAPRAASML LTPQSSSLATSALTHWAISL PPLPQGLVFS in isoform 2.
    VSP_025816Add
    BLAST

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221A → V in AAH92543. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK017931 mRNA. Translation: BAB31009.1.
    AK044073 mRNA. Translation: BAC31763.1.
    AK153576 mRNA. Translation: BAE32105.1.
    AL806523 Genomic DNA. Translation: CAM23957.1.
    BC092543 mRNA. Translation: AAH92543.1.
    CCDSiCCDS18148.1. [Q562D6-2]
    RefSeqiNP_083362.1. NM_029086.2. [Q562D6-2]
    XP_006538388.1. XM_006538325.1. [Q562D6-1]
    UniGeneiMm.45973.

    Genome annotation databases

    EnsembliENSMUST00000030015; ENSMUSP00000030015; ENSMUSG00000028331. [Q562D6-1]
    ENSMUST00000086563; ENSMUSP00000083752; ENSMUSG00000028331. [Q562D6-2]
    GeneIDi74753.
    KEGGimmu:74753.
    UCSCiuc008stq.1. mouse. [Q562D6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK017931 mRNA. Translation: BAB31009.1 .
    AK044073 mRNA. Translation: BAC31763.1 .
    AK153576 mRNA. Translation: BAE32105.1 .
    AL806523 Genomic DNA. Translation: CAM23957.1 .
    BC092543 mRNA. Translation: AAH92543.1 .
    CCDSi CCDS18148.1. [Q562D6-2 ]
    RefSeqi NP_083362.1. NM_029086.2. [Q562D6-2 ]
    XP_006538388.1. XM_006538325.1. [Q562D6-1 ]
    UniGenei Mm.45973.

    3D structure databases

    ProteinModelPortali Q562D6.
    SMRi Q562D6. Positions 27-221.
    ModBasei Search...

    Protein-protein interaction databases

    IntActi Q562D6. 1 interaction.
    MINTi MINT-8414996.

    PTM databases

    PhosphoSitei Q562D6.

    Proteomic databases

    PRIDEi Q562D6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030015 ; ENSMUSP00000030015 ; ENSMUSG00000028331 . [Q562D6-1 ]
    ENSMUST00000086563 ; ENSMUSP00000083752 ; ENSMUSG00000028331 . [Q562D6-2 ]
    GeneIDi 74753.
    KEGGi mmu:74753.
    UCSCi uc008stq.1. mouse. [Q562D6-1 ]

    Organism-specific databases

    MGIi MGI:1922003. 5830415F09Rik.

    Phylogenomic databases

    eggNOGi COG1720.
    GeneTreei ENSGT00390000004643.
    HOGENOMi HOG000231645.
    HOVERGENi HBG054288.
    OMAi YEIACAP.
    TreeFami TF331670.

    Miscellaneous databases

    NextBioi 341560.
    PROi Q562D6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q562D6.
    CleanExi MM_5830415F09RIK.
    Genevestigatori Q562D6.

    Family and domain databases

    Gene3Di 2.40.30.70. 1 hit.
    InterProi IPR023370. TsaA-like.
    IPR001378. UPF0066.
    IPR023368. UPF0066_cons_site.
    [Graphical view ]
    Pfami PF01980. UPF0066. 1 hit.
    [Graphical view ]
    SUPFAMi SSF118196. SSF118196. 2 hits.
    TIGRFAMsi TIGR00104. YaeB_AF0241. 1 hit.
    PROSITEi PS01318. TSAA_1. 1 hit.
    PS51668. TSAA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Strain: C57BL/6J.
      Tissue: Brain cortex and Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.

    Entry informationi

    Entry nameiNAP1_MOUSE
    AccessioniPrimary (citable) accession number: Q562D6
    Secondary accession number(s): Q3U5H3, Q8BRJ8, Q9D3F5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: July 9, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi